Drug Delivery Nanosystems for Biomedical Applications

Drug Delivery Nanosystems for Biomedical Applications

Micro and Nano Technologies
2018, Pages 33-44
Drug Delivery Nanosystems for Biomedical Applications

Chapter 3 - Safety and toxicity concerns of nanosystems

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Abstract

Nanotoxicology, a study related to the safety concerns of nanomaterials, is a rapidly expanding area of research in the field of toxicology owing to the wide applications of nanomaterials in a multidisciplinary scenario. The unique physicochemical properties make nanoparticles interact with the biological systems causing unpredictable as well as undesirable consequences. Hence, a throughput investigation into nano-bio interaction is warranted to ensure the proper and safe use of nanomaterials. This chapter includes a review of possible interactions of nanomaterial at the cellular and molecular levels.

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    These results further confirmed the ability of nanoformulations to enhance drug delivery compared to QC solution leading to a decrease in tumor volume that was reflected as a decrease in tumor serum biomarker CA 19-9. Safety of the prepared nanoformulations remained the most important question to be answered since the development of nanosystems for drug delivery [79]. Nanoparticles have very small size and large surface area resulting in a change in their physicochemical properties which might have some undesirable effect on body organs.

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