The influence of pallidal deep brain stimulation on striatal dopaminergic metabolism in the rat
Section snippets
Acknowledgements
We wish to thank C. Koelske, R. Winter and M. Witt for their excellent technical assistance. This study was supported by DFG grant Ku 830/3–1, 3–3 and EU grant QLRT-1999–02173.
References (19)
- et al.
The connections of the dopaminergic system with the striatum in rats and primates. An analysis with respect to the functional and compartmental organization of the striatum
Neuroscience
(2000) - et al.
Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
Exp. Neurol.
(1998) - et al.
Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice
Brain Res.
(1992) - et al.
Pallidal stimulation for Parkinson's disease. Two targets?
Neurology
(1997) - et al.
Comparison of pallidal and subthalamic nucleus deep brain stimulation for advanced Parkinson's disease: results of a randomized, blinded pilot study
Neurosurgery
(1999) - et al.
Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms
Nat. Med.
(1997) - et al.
Acute and chronic effects of anteromedial globus pallidus stimulation in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry
(1999) - et al.
Pallidotomy increases activity of motor association cortex in Parkinson's disease: a positron emission tomographic study
Ann. Neurol.
(1995) - et al.
High-frequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases
J. Neurosurg.
(1997)
Cited by (14)
Experimental deep brain stimulation in rodent models of movement disorders
2022, Experimental NeurologyCitation Excerpt :Even though both EP DBS and STN DBS were shown to improve motor performance and cognition in hemiparkinsonian 6-OHDA rats in a stimulation frequency-dependent manner (Summerson et al., 2014), the mechanism behind EP DBS differs from STN DBS, as EP DBS modulates extracellular striatal glutamate levels (Lee et al., 2019). Moreover, the influence on striatal dopamine metabolism and the neuroprotective effect on the SN dopaminergic neurons described for STN DBS couldn't be observed after EP DBS (Fischer et al., 2015; Lee et al., 2019; Meissner et al., 2000). Tucker et al., 2019 examined the ventroanterior (VA) and ventrolateral (VL) motor nuclei of the thalamus as new DBS targets in a hemiparkinsonian 6-OHDA rat model (Tucker et al., 2021; Tucker et al., 2019).
The basal ganglia as a substrate for the multiple actions of amphetamines
2011, Basal GangliaCitation Excerpt :Cortical ablations or chronic DA depletions, such as those observed after large doses of amphetamines alter the rate and pattern of activity of the STN [95]. Deep brain stimulation of the STN has been shown to increase DA release in the striatum [96–98], the latter being related to development of incentive salience and increased motivational and emotional value for drugs of abuse and the environmental context in which they are generally taken [99,100]. Stimulation of the STN induces the development of LTP in the SNc cell bodies [101], which could increase DA released from terminals in the striatum, and provide a molecular substrate for behavioral sensitization caused by psychostimulant drugs [101,102].
The time course of the return of upper limb bradykinesia after cessation of subthalamic stimulation in Parkinson's disease
2007, Parkinsonism and Related DisordersCitation Excerpt :Despite use of different methods, this indicates that several mechanisms with different time constants constitute the benefit of STN stimulation on motor parameters. One of these mechanisms may be a desinhibition of substantia nigra compacta neurons by STN stimulation, which then causes an increase of striatal dopa metabolites during the following 40 min [9]. These long-term effects cannot be investigated during the implantation or during post-operative tests.
Matching geometry and stimulation parameters of electrodes for deep brain stimulation experiments - Numerical considerations
2006, Journal of Neuroscience MethodsChoosing electrodes for deep brain stimulation experiments-electrochemical considerations
2005, Journal of Neuroscience Methods