Original ArticleEnhanced Preproenkephalin-B–Derived Opioid Transmission in Striatum and Subthalamic Nucleus Converges Upon Globus Pallidus Internalis in L-3,4-dihydroxyphenylalanine–Induced Dyskinesia
Section snippets
Animals
Seventeen female cynomolgus monkeys (Macaca fascicularis, SAH, Beijing, China) were used for this study. Animals were housed in individual primate cages under controlled conditions of humidity (50% ± 5%), temperature (24 ± 1°C), and light (12-hour light/dark cycles, lights on at 8:00 am); food and water were available ad libitum, and animal care was supervised by veterinarians skilled in the health care and maintenance of nonhuman primates. Experiments were carried out in accordance with
Total Opioid Binding Sites
The MPTP lesion and L-dopa treatment did significantly affect the [3H] diprenorphine binding (Figure 2A) in the putamen [for example in the caudal putamen; treatment effect: F(3,63) = 4.19, p = .01; but no quadrant effect: F(3,63) = .39, p = .76 nor interaction: F(9,63) = .06, p = .99] and in the GPi, the main output structure of basal ganglia [F(3,15) = 3.74, p = .04] but not in the caudate nucleus [caudal caudate: F(3,15) = 2.57, p = .1] or in the GPe [F(3,15) = 2.93, p = .08]. Although post
Discussion
The MPTP-lesioned monkey model of PD has been used to show that, at the peak of L-dopa effect, abnormal transmission of PPE-B–derived opioid coming from the striatum and the STN converges upon GPi concomitantly with LID expression. Enhanced transmission is ascertained by the concomitant increased striatal and subthalamic PPE-B mRNA levels and the decrease in total opioid, μ, and κ receptor binding in GPi.
Confirmation was obtained that DA-denervation induces a significant upregulation of PPE-A
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