International Journal of Oral and Maxillofacial Surgery
Systematic ReviewClinical PathologyHistologic findings and related diagnostic methods in condylar hyperactivity
Section snippets
Material and Methods
This systematic review was conducted according to the PRISMA guidelines32 and the PICO question was: for patients affected by CH (P), are histological (I) or clinical/imaging diagnostic tools (C) able to describe a characteristic disease pattern (O)?
Results
An initial source of 660 articles was identified after duplicates removal (κ = 0.78). Of these, 579 were dismissed after revising titles/abstracts, resulting in 81 articles eligible for full-text analysis (κ = 0.8). Then, 64 articles were excluded when revised against the inclusion criteria. Finally, 17 articles (Fig. 1) were included in the review (κ = 0.8)3, 4, 5, 6, 8, 11, 17,26, 27, 29, 35, 36, 37, 38, 39, 40, 41. Eleven articles were case series and six were cross-sectional studies. The data
Discussion
Taken together, these results confirm that there is no consensus on a characteristic histological description in CH. Two of the main contributors to this lack of histological consensus are the heterogeneity found among the diagnostic methods used and the RoB of the included articles. Beyond the methodological issues mentioned, another explanation for this could be the clinical scenario that CH entails, where there is no possibility of having a reliable control sample of the contralateral
Funding
None.
Competing interests
None.
Ethical approval
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2023, International Journal of Oral and Maxillofacial SurgeryCitation Excerpt :The common histopathological features mentioned above could well be related to the age of the specimens, and the available studies on this subject show a high risk of bias. Other authors have also concluded that condylar hyperplasia is a diagnosis based on a combination of clinical evaluation, imaging, and histological evaluation.16 Together with the long follow-up period, the combined gold standard used in the present study aims to overcome the disadvantages of using a single gold standard.
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These authors contributed equally to this work.