iScience
Volume 25, Issue 2, 18 February 2022, 103694
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Article
Increased neutralization of SARS-CoV-2 Delta variant after heterologous ChAdOx1 nCoV-19/BNT162b2 versus homologous BNT162b2 vaccination

https://doi.org/10.1016/j.isci.2021.103694Get rights and content
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open access

Highlights

  • Heterologous ChAd/BNT vaccination is highly immunogenic

  • Delta VoC neutralization is increased after heterologous ChAd/BNT vaccination

  • This effect is attributable to women with sick leave after second vaccination

  • IgA levels are overall low, but higher after BNT/BNT vaccination

Summary

Heterologous SARS-CoV-2 vaccine approaches with a second mRNA-based vaccine have been favored in the recommendations of many countries over homologous vector-based ChAdOx1 nCoV-19 vaccination after reports of thromboembolic events and lower efficacy of this regimen. In the middle of 2021, the SARS-CoV-2 Delta variant of concern (VoC) has become predominant in many countries worldwide. Data addressing the neutralization capacity of a heterologous ChAdOx1 nCoV-19/mRNA-based vaccination approach against the Delta VoC in comparison to the widely used homologous mRNA-based vaccine regimen are limited. Here, we compare serological immune responses of a cohort of ChAdOx1 nCoV-19/BNT162b2-vaccinated participants with those of BNT162b2/BNT162b2 vaccinated ones and show that neutralization capacity against the Delta VoC is significantly increased in sera of ChAdOx1 nCoV-19/BNT162b2-vaccinated participants. This overall effect can be attributed to ChAdOx1 nCoV-19/BNT162b2-vaccinated women, especially those with more severe adverse effects leading to sick leave following second immunization.

Subject areas

Immunology
Immune response

Data and code availability

  • Datasets generated in this study have been uploaded to Mendeley Data: https://doi.org/10.17632/tzncbsfgkk.1.https://data.mendeley.com . Sequence of SARS-CoV-2 Delta VoC used for neutralization assay is available under GenBank: OK_149285. .

  • This paper does not report original code.

  • Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

Cited by (0)

4

These authors contributed equally

5

Lead contact