Journal of the American Academy of Child & Adolescent Psychiatry
New researchChronotype, Longitudinal Volumetric Brain Variations Throughout Adolescence, and Depressive Symptom Development
Section snippets
Participants
Neuroimaging and clinical data were obtained from an existing large European multisite longitudinal study of adolescent development, IMAGEN (https://imagen-project.org/). A detailed description of recruitment and assessment procedures, with exclusion and inclusion criteria, has been published elsewhere.23 Notably, any obvious psychopathology at baseline (eg, bipolar disorder, schizophrenia, or major neurodevelopmental disorders), any severe medical somatic conditions, any history of head
Baseline Characteristics
Significant MESC-by-sex interaction was found for age and bedtime during weekdays. At baseline, MESC score (continuous) was associated with all the sleep characteristics except time in bed during weekdays (Table 1; Table S1, available online). Furthermore, MESC score (continuous) correlated with bedtime during weekdays in boys, but not in girls. Lower MESC score (continuous, ie, higher eveningness) also correlated with lower NEO Five-Factor Inventory (NEO-FFI) conscientiousness dimension score,
Discussion
In the present study, we investigated for the first time the association between regional GMV at age 14 and 19 and chronotype at age 14, explored the specificity of these changes compared with changes associated with chronotype sleep-related characteristics, and determined the association of such changes with later depressive symptoms. We observed that eveningness (both continuous and categorical) was associated with larger GMV in the right mPFC at age 14 and 5 years later at age 19. GMV in the
CRediT authorship contribution statement
Hélène Vulser: Writing – review & editing, Writing – original draft, Software, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation, Conceptualization. Hervé S. Lemaître: Writing – review & editing, Writing – original draft, Validation, Supervision, Software, Methodology, Formal analysis, Conceptualization. Stella Guldner: Writing – review & editing, Writing – original draft, Methodology, Investigation, Conceptualization. Pauline Bezivin-Frère: Writing – review &
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Cited by (0)
Dr. Martinot and Prof. Nees contributed equally to this work.
This work received support from the following sources: European Union–funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT-2007-037286), ANR (ANR-12-SAMA-0004 and AAPG2019–GeBra), Eranet Neuron (AF12-NEUR0008-01–WM2NA and ANR-18-NEUR00002-01–ADORe), Fondation de France (00081242), Fondation pour la Recherche Médicale (DPA20140629802), Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012, Fondation de l’Avenir (AP-RM-17-013), Fédération pour la Recherche sur le Cerveau, Horizon 2020–funded ERC Advanced Grant STRATIFY (Brain network based stratification of reinforcement-related disorders) (695313), Human Brain Project (HBP SGA 2, 785907 and HBP SGA 3, 945539), National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, Deutsche Forschungsgemeinschaft (SM 80/7-2, SFB 940, TRR 265, NE 1383/14-1), Medical Research Foundation and Medical Research Council (MR/R00465X/1 and MR/S020306/1). The INSERM and the Strasbourg University and SATT CONECTUS provided sponsorship (PI: Jean-Luc Martinot). Dr. Vulser was supported by post-doctoral fellowships from the Fondation Servier and Fondation Pierre Deniker. The funding sources had no involvement in the study design; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the article for publication.
The study protocol was approved by the Ethics Committee of Paris CPP IDF-VII.
Consent has been provided for descriptions of specific patient information.
This study was presented as an oral presentation at the 18ème édition du Congrès de l’Encéphale; January 22-24, 2020; Paris, France.
Dr. Lemaître served as the statistical expert for this research.
Disclosure: Dr. Stringaris has reported being a coauthor of the Affective Reactivity Index (ARI), a cost-free psychometric instrument. He has received royalties from Cambridge University Press for The Maudsley Reader in Phenomenological Psychiatry and Oxford University Press for Disruptive Mood: Irritability in Children and Adolescents. Dr. Banaschewski has served in an advisory or consultancy role for ADHS digital, InfectoPharm, Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Roche, and Takeda. He has received conference support or speaker’s fees from Medice and Takeda. He has received royalties from Hogrefe, Kohlhammer, CIP Medien, and Oxford University Press. He has been involved in clinical trials conducted by Shire and Viforpharma. Dr. Poustka has served in an advisory or consultancy role for Roche and Viforpharm and has received speaker’s fees from Takeda, Medice, and InfectoPharm. She has received royalties from Hogrefe, Kohlhammer, and Schattauer. Drs. Vulser, Lemaître, Bezivin-Frère, Löffler, Sarvasmaa, Massicotte-Marquez, Artiges, Paillère Martinot, Filippi, van Noort, Penttilä, Grimmer, Becker, Bokde, Desrivières, Garavan, Grigis, Gowland, Heinz, Papadopoulos Orfanos, Smolka, Spechler, Walter, Whelan, Profs. Schumann and Flor, Dr. Martinot, Prof. Nees, Ms. Guldner, Mr. Miranda, and Ms. Fröhner have reported no biomedical financial interests or potential conflicts of interest.
Author Contributions
Conceptualization: Vulser, Lemaître, Guldner, Löffler, Sarvasmaa, Massicotte-Marquez, Paillère Martinot, Flor, Martinot
Data curation: Vulser, Bezivin-Frère, Sarvasmaa, Artiges, Miranda, Garavan, Grigis, Papadopoulos Orfanos, Spechler
Formal analysis: Vulser, Lemaître
Funding acquisition: Vulser, Löffler, Flor, Martinot, Nees
Investigation: Vulser, Guldner, Nees
Methodology: Vulser, Lemaître, Guldner, Bezivin-Frère, Löffler, Artiges, Filippi, Miranda, Spechler, Flor, Nees
Project administration: Banaschewski, Bokde, Desrivières, Fröhner, Gowland, Heinz, Papadopoulos Orfanos, Poustka, Smolka, Walter, Whelan, Schumann, Flor, Martinot, Nees
Resources: Artiges, Filippi, Stringaris, van Noort, Penttilä, Grimmer, Becker, Flor, Martinot, Nees
Software: Vulser, Lemaître, Bezivin-Frère, Filippi, Miranda
Supervision: Lemaître, Flor, Nees
Validation: Lemaître, Löffler, Stringaris, van Noort, Penttilä, Grimmer, Becker, Garavan, Nees
Visualization: Nees
Writing – original draft: Vulser, Lemaître, Guldner, Flor, Martinot, Nees
Writing – review and editing: Vulser, Lemaître, Guldner, Bezivin-Frère, Löffler, Sarvasmaa, Massicotte-Marquez, Artiges, Paillère Martinot, Filippi, Miranda, Banaschewski, Bokde, Desrivières, Fröhner, Grigis, Gowland, Heinz, Papadopoulos Orfanos, Poustka, Smolka, Spechler, Walter, Whelan, Schumann, Flor, Martinot, Nees
The IMAGEN Consortium collaborators: https://imagen-project.org/.
The radiographer staff at Centre de NeuroImagerie de Recherche de l’Institut du Cerveau et de la Moelle épinière (http://www.cenir.org/mri.html?lang=en) is acknowledged for support in magnetic resonance imaging datasets acquisition.