ReviewDiet and psoriasis, part II: Celiac disease and role of a gluten-free diet
Section snippets
Methods
We searched the electronic MEDLINE database via PubMed using search terms “psoriasis” combined with “celiac disease,” “celiac sprue,” and “gluten,” respectively. We limited our search to articles available in English and those published between 1960 and 2012. Manual searches of bibliographies of the articles were also performed to identify additional studies to be included. We focused on population-based studies examining the co-occurrence of psoriasis and celiac disease, investigations of
Population studies
Several studies have found that patients with psoriasis are at increased risk for celiac disease. A retrospective cohort study comparing 25,341 patients with psoriasis with more than 125,000 matched control subjects in the US Southern California Kaiser Permanente database showed an odds ratio of 2.2 for the association of psoriasis with celiac disease.3 Similarly, a case-control study comparing 12,502 patients with psoriasis with 24,285 age- and sex-matched control subjects using an Israeli
Discussion
It is well established that patients with psoriasis are more likely to have concurrent autoimmune diseases, particularly those affecting the gastrointestinal tract such as Crohn's disease and ulcerative colitis.3, 4 Here we document that another such autoimmune disease is celiac disease, with a recent large study showing that patients with psoriasis have 2.2-fold risk of being given a diagnosis of celiac disease compared with matched control subjects.3 We perform a meta-analysis to show that
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Ms Bhatia and Dr Millsop contributed equally to this work.
Dr Liao is supported in part by grants from the National Institutes of Health (R01AR065174, K08AR057763). Dr Linos is supported by the National Center for Research Resources (KL2RR024130) and Dermatology Foundation.
Disclosure: Dr Koo is a speaker for AbbVie and Leo. Dr Koo conducts research for Amgen, Janssen, Novartis, Photomedex, Galderma, Pfizer, and Merck. Dr Koo has no stocks, employment, or board memberships with any pharmaceutical company. None of the grants were directly related to this study. Ms Bhatia, Ms Millsop, Ms Debbaneh, Dr Linos, and Dr Liao have no conflicts of interest to declare.