Trauma/BurnsMicroRNA expression profiles in the esophagus of children with caustic stenosis: A pathway towards esophageal cancer?
Section snippets
Ethics statement
This study was performed in accordance with the ethical standards of the Declaration of Helsinki and according to national and international guidelines. Our study has been approved by the Research Ethics Boards of the Faculty of Medicine (FMB), UNESP, Botucatu, SP (REB #1089452/2015).
Patient samples
Patients who met inclusion criteria were those who were less than 15 years of age and with a history of hospital admission owing to an esophageal lesion induced by caustic ingestion, who have been subjected to
Patient demographic and clinical data
We analyzed 27 biopsies from 15 patients with esophageal caustic lesions. These samples were divided into two groups, 15 in Group A (less than five years of follow-up since injury) and 12 in Group B (more than five years of follow-up since injury). Given that patient follow-up was > 17 years, some of them have samples included in both groups. Demographic data and information on clinical features are shown in Table 1.
Deregulated miRNA expression in esophageal samples exposed to caustic ingestion
miRNA expression analysis of Group A cases showed that 13 significantly
Discussion
Changes in miRNA expression are known to contribute to cancer development and progression, with different miRNA expression profiles associated with distinct biological tumor behavior [33]. The pathophysiologic mechanism of esophageal cancer related to caustic ingestion is not well understood [11]. Pathological findings have shown that the epithelium overlying an injured area is vulnerable to neoplastic transformation, especially if subjected to chemical, physical, or thermal aggression for
Conclusions
miRNAs identified here may be associated with malignant transformation from caustic stenosis to esophageal cancer and may serve as future novel biomarkers of malignant progression. This study provides a theoretical basis for future research in this field with this specific pediatric population suffering from caustic exposure. Further investigation is needed to elucidate the mechanisms underlying malignant transformation associated with caustic stenosis. High-risk patients with caustic lesions
Acknowledgments
Research funds were obtained in part from the Brazilian Coordination for the Improvement of Higher Level Education Personnel (CAPES - Brazil) grant #2014/458734-4 to EVPO. GVP was funded through São Paulo Research Foundation (FAPESP - Brazil) scholarship # 2015/03287-4.
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Permanent Address: Department of Pediatric Surgery, Barretos Children's Cancer Hospital from Barretos Cancer Center – Hospital de Cancer de Barretos: Unidade Infantojuvenil; Barretos Medical School – Faculdade de Ciencias da Saúde “Dr Paulo Prata” (FACISB); Av. João Baroni, 3025-Dr. Paulo Prata, Barretos-SP, CEP: 14784-390, Barretos, SP, BRAZIL. Telephone: + 55 (17) 3321 5400.