Elsevier

Materials Science and Engineering: C

Volume 41, 1 August 2014, Pages 232-239
Materials Science and Engineering: C

Key parameters in blood-surface interactions of 3D bioinspired ceramic materials

https://doi.org/10.1016/j.msec.2014.04.058Get rights and content

Highlights

  • Two types of porous bioinspired ceramic samples were morphologically characterized.

  • 3D ceramic-blood interactions were evaluated according to ISO 10993-4.

  • Topography and microstructure effects on blood-surface response were identified.

  • Surface wettability was found to be a key factor for most of the interactions studied.

  • The clinical relevance of the parameters studied is discussed.

Abstract

Direct contact of materials with blood components may trigger numerous processes which ultimately lead to hemolysis, clot formation and recruitment of inflammatory cells. In this study, the blood-surface interactions for two inert bioinspired ceramic scaffolds obtained from natural resources; biomorphic carbon and silicon carbides (bioSiC) from different origins have been studied. The response of the blood in contact with carbon is well known, however little has been identified on the influence of their 3D porous structure. Moreover, to our knowledge, there is no reference in the literature about the hemocompatibility of biomorphic silicon carbide as a porous scaffold. The experimental results showed the surface energy to be crucial to evaluate the hemocompatibility of a material however the surface topography and material porosity are also parameters to be considered. Surface roughness modifies clot formation whereas for protein adsorption total sample porosity seems to be the key parameter to be considered for hydrophilic materials (biomorphic silicon carbides), while the size of the pores determines the hemolytic response.

Abbreviations

3D
three dimensional
bioSiC
biomorphic silicon carbide
C
pyrolitic carbon
CCA
Complement convertase attachment

Keywords

Biomorphic silicon carbide
Pyrolitic carbon
Three-dimensional ceramic matrix
Surface-blood interactions
Inflammatory response

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