Neuron
Volume 76, Issue 3, 8 November 2012, Pages 565-578
ArticleZinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface
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Highlights
► Kainate receptors containing GluK3 are potentiated by zinc ► Zinc stabilizes the LBD interface, decreasing desensitization and glutamate EC50 ► The zinc binding site is at the interface between ligand binding domains (LBDs) ► GluK2/GluK3 receptors have a binding site distributed on both subunit LBDs
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These authors contributed equally to this work
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Present address: Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark
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