Brief ReportBasolateral amygdala noradrenergic activity is involved in the acquisition of conditioned odor aversion in the rat
Section snippets
Acknowledgments
We thank Martı´n Garcı´a Guzmán for the animal maintenance, Cipriana López and Mireya Romero for technical assistance, and Shaun Harris for the English revision of the final text. This work was supported by IN219605-03, Conacyt 46161-M and 46754-Q (MIM) and by ANR-05-PNRA-002 AROMALIM (GF).
References (20)
- et al.
Effects of catecholaminergic depletion of the amygdala and insular cortex on the potentiation of odor by taste aversions
Behavioral and Neural Biology
(1993) - et al.
Bicuculline administration into basolateral amygdala facilitates trace conditioning of odor aversion in the rat
Neurobiology of Learning and Memory
(1997) - et al.
Role of norepinephrine in mediating stress hormone regulation of long-term memory storage: A critical involvement of the amygdala
Biological Psychiatry
(1999) - et al.
Neuroanatomical and functional specificity of basolateral amygdaloid nucleus in taste potentiated odor aversion
Neurobiology of Learning and Memory
(1995) - et al.
Norepinephrine release in the amygdala in response to footshock stimulation
Neurobiology of Learning and Memory
(1996) - et al.
Amygdala N-methyl-d-aspartate receptors participate in the induction of long-term potentiation in the dentate gyrus in vivo
Neuroscience Letters
(1995) - et al.
The locus–coeruleus, norepinephrine and memory in newborns
Brain Research Bulletin
(1994) - et al.
A synaptic model of memory: Long-term potentiation in the hippocampus
Nature
(1993) - et al.
Noradrenaline modulates glutamate-mediated neurotransmission in the rat basolateral amygdala in vitro
European Journal of Neuroscience
(1997) - et al.
Facilitation of conditioned odor aversion learning by entorhinal cortex lesions in the rat
Behavioral Neuroscience
(1996)
Cited by (30)
Micro-injection of propranolol within basolateral amygdala impaired fear and spatial memory and dysregulated evoked responses of CA1 neurons following foot shock stress in rats
2021, Brain Research BulletinCitation Excerpt :Systemic post-training injection of the agonist and antagonist of adrenoceptors increase and disrupt memory. However, injecting a β-adrenoceptor antagonist into the amygdala does not affect the retrieval of conditioned flavor aversion (Miranda et al., 2007). Therefore, the exact role of the β-adrenoceptor of BLA on memory is far from clear.
Noradrenergic regulation of the basolateral amygdala
2020, Handbook of Behavioral NeuroscienceCB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory
2019, Current BiologyNoradrenergic β-receptor antagonism in the basolateral amygdala impairs reconsolidation, but not extinction, of alcohol self-administration: Intra-BLA propranolol impairs reconsolidation of alcohol self-administration
2018, Neurobiology of Learning and MemoryCitation Excerpt :Propranolol hydrochloride (PROP; Sigma, Australia) was freshly dissolved in dH20 prior to infusions, and was prepared at a concentration of 2 µg/0.2 µl for all experiments. This drug dose was based on pilot data from our laboratory and is consistent with other reports in the literature (Miranda, Ferry, & Ferreira, 2007; Miranda, Rodriguez-Garcia, Reyes-Lopez, Ferry, & Ferreira, 2008). For the drug infusions, internal infusion cannula were attached to 25 μl Hamilton syringes via polyethylene tubing, which were connected to a syringe pump (Harvard Apparatus; PHD 22/2000).
Modulation of the magnitude of conditioned taste aversion in rats with excitotoxic lesions of the basolateral amygdala
2017, Neurobiology of Learning and MemoryCitation Excerpt :Activation of pathways that include basolateral amygdala, medial prefrontal cortex, and nucleus accumbens has been described for odor conditioning (McGinty & Grace, 2008), and changes in extracellular signals of the prefrontal cortex and nucleus accumbens have been related to the acquisition and expression of conditioned taste aversion (Marotta et al., 2014). Similarly, basolataral amygdala and its cortical and subcortical connections have been implicated in the acquisition of conditioned odor aversion (Miranda, Ferry, & Ferreira, 2007) and taste-potentiated odor aversion (Ferry et al., 1995). More specifically, it has been shown that taste-potentiated odor aversion memory involves the activity of the basolateral amygdala and the medial and orbito-frontal cortices (Dardou, Datiche, & Cattarelli, 2007).
Within-event learning in rats with lesions of the basolateral amygdala
2013, Behavioural Brain ResearchCitation Excerpt :It has been reliably demonstrated, however, that procedures that disrupt the normal functioning of the BLA attenuate or eliminate TPOA. This result was first demonstrated in studies using electrolytic lesions [13] but has since been obtained with neurotoxic lesioning techniques [14,15], and with infusions into the BLA of the GABA receptor agonist muscimol [16] of the NMDA antagonist APV [17,18], of lidocaine [19] and of the noradrenalin antagonist propanolol [20]. Hatfield and Gallagher [17] further reported that the TPOA shown by normal animals in their training preparation is sensitive to the effects of extinguishing the taste, confirming the interpretation that the effect depends on the formation of the within-event, odor–taste association.