Rapid CommunicationAcquisition of specific response–outcome associations requires NMDA receptor activation in the basolateral amygdala but not in the insular cortex
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Acknowledgments
This work was supported by the French ANR-14-CE13-0014 GOAL Grant awarded to EC and GF. SP was recipient of a post-doctoral fellowship from Région Aquitaine (2014) and INRA (2015–2016) and the AgreenSkills fellowship programme (2014–2016) which has received funding from the EU’s Seventh Framework Programme under Grant agreement N° FP7-267196. We thank Yoan Salafranque for the care provided to the animals during the experiments.
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Medial orbitofrontal neurotrophin systems integrate hippocampal input into outcome-specific value representations
2022, Cell ReportsCitation Excerpt :Another consideration in our projection-specific inactivation experiments is that vHC projections to the MO can collateralize to the insular cortex (IC) (Verwer et al., 1997). We think that these collaterals likely did not grossly affect outcomes here, because the IC is associated with Pavlovian (and not instrumental) conditioning (Kusumoto-Yoshida et al., 2015; Nasser et al., 2018; Parkes et al., 2016), including CTA (Ferreira et al., 2002; Gutiérrez et al., 1999), such that inactivation disrupts avoidance of a LiCl-paired food. By contrast, none of our manipulations disrupted CTA, and we did not detect fluorescence in the IC in projection-specific inactivation experiments, suggesting that IC collaterals were sparse and did not grossly affect our experiments (Figure S6).
Prefrontal regulation of behavioural control: Evidence from learning theory and translational approaches in rodents
2020, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Their specific involvement was then revealed using temporary inactivation procedures which showed that outcome devaluation is impaired when perturbation of mOFC (Bradfield et al., 2015; Gourley et al., 2016) or IC (Parkes and Balleine, 2013; Parkes et al., 2015, 2018) activity was restricted to the choice test and the devaluation effect is facilitated when mOFC is chemogenetically activated during the test (Gourley et al., 2016). Notably, inhibition of IC during acquisition or satiety-induced devaluation does not impair goal-directed behaviour (Parkes et al., 2018, 2016). Both mOFC and IC are therefore necessary for retrieving a mental representation of the current outcome value (i.e., the value of an absent outcome) to guide action selection but not for the acquisition of instrumental actions or the encoding of outcome value.
Striatopallidal adenosine A<inf>2A</inf> receptors in the nucleus accumbens confer motivational control of goal-directed behavior
2020, NeuropharmacologyCitation Excerpt :The NAc receives excitatory glutamatergic afferents from “limbic” structures such as the basolateral amygdala and the medial prefrontal cortices (Britt et al., 2012; Sciascia et al., 2015). Focal infusion of NMDA receptor antagonist into NAc (Dalley et al., 2005), DMS(Yin et al., 2005a) and BLA (input to NAc) (Parkes et al., 2016) reveals that the activation of glutamatergic striatal pathway is required for coding action-outcome association during the acquisition of the instrumental behavior, particularly by the early consolidation of appetitive Pavlovian learning. Mice with conditional knock-out of the NMDAR in the indirect pathway displayed a delay in goal-directed learning, lack of associative behavior, and impairment in action selection or skill learning (Lambot et al., 2016), while the mice with dopaminergic neuron-specific NMDAR1 deletion displayed impaired habit-learning with normal goal-directed learning and spatial reference memories (Harnett et al., 2009).
Pre-training inactivation of basolateral amygdala and mediodorsal thalamus, but not orbitofrontal cortex or prelimbic cortex, impairs devaluation in a multiple-response/multiple-reinforcer cued operant task
2020, Behavioural Brain ResearchCitation Excerpt :While there was indirect evidence from previous comparisons of pre- vs. post-training permanent lesions or NMDA receptor antagonism that this would be the case, our results more directly tested the effects of decreasing general neuronal function exclusively during operant training. BLA is necessary for goal-directed action in most devaluation tasks [8–10,17–22], and there is evidence that NMDA receptor blockade limited to the operant training phase can impair later devaluation in a free-operant task [22]. One research study in rats comparing the effects of pre- vs. post-training permanent lesions suggested that impairment in function during the initial acquisition phase (for Pavlovian conditioning) is sufficient to impair later devaluation if only one reinforcer is used in initial training [19].
Cortical determinants of goal-directed behavior
2018, Goal-Directed Decision Making: Computations and Neural CircuitsThe effect of high-fat diet consumption on appetitive instrumental behavior in rats
2017, AppetiteCitation Excerpt :In contrast, HFD intake is associated with augmented amygdala-dependent emotional memories and enhanced neuronal activation in the basolateral complex of the amygdala (BLA; Boitard et al., 2015). The BLA is critical for the acquisition of instrumental responding (Parkes, Ferreira, & Coutureau, 2016) as well as for encoding changes in the value of food rewards (Parkes & Balleine, 2013; Wassum, Ostlund, Maidment, & Balleine, 2009). Over-activation of the BLA, as a result of HFD intake, may therefore lead to changes in reward learning and instrumental performance.
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These authors contributed equally.