Trends in Cancer
Volume 3, Issue 8, August 2017, Pages 546-550
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Multiregional Tumor Trees Are Not Phylogenies

https://doi.org/10.1016/j.trecan.2017.06.004Get rights and content
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Tumor samples most often comprise a mixture of different cell lineages. Multiregional trees built from bulk mutational profiles do not consider this heterogeneity and can potentially lead to erroneous evolutionary inferences, including biased timing of somatic mutations, spurious parallel mutation events, and/or incorrect chronological ordering of metastatic events.

Keywords

bulk sequencing
intratumor genetic heterogeneity
multiregional studies
somatic evolution
tumor phylogenies

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