ReviewNew aspects in the pathogenesis of abomasal displacement
Introduction
The first reports of abomasal displacement (AD) in cattle were published in the 1950s (Begg, 1950, Moore et al., 1954) and, since then, the occurrence of the condition has continued to increase. In recent studies in North America, the mean lactation incidence of AD was estimated to range between 3% and 5% (Gröhn et al., 1998, Zwald et al., 2004a, LeBlanc et al., 2005) although an incidence rate of 10%, even up to 20%, has been observed in individual herds (Dawson et al., 1992, Pehrson and Stengärde, 2000). In Germany, the mean lactation incidence in German Holstein herds has been estimated at 1.6% (Wolf et al., 2001a) and up to 7.5% in individual herds (Poike and Fürll, 2000).
The economic losses from AD include reduced milk production and the cost of treatment or culling. Studies using a 305 day milk yield have estimated average milk loss from left AD of 11% (Martin et al., 1978) and 7.5% (Dohoo and Martin, 1984). Compared to healthy cows, cows with left AD in parity, particularly with twins, lost an average of 700 kg of milk, with the highest losses occurring in high yielding cows (Detilleux et al., 1997).
Evidence from epidemiological and experimental studies over the last 50 years have identified a variety of risk factors associated with the occurrence of AD. However, the primary cause of the disease remains unknown. In 1961, Dirksen postulated that an abomasal motility disorder (hypotony or atony) occurred prior to inflation of the organ (Dirksen, 1961), a hypothesis that has been supported by other researchers. Impaired motility prevented gases (mainly methane and CO2 produced either in the abomasum or passed into it from the forestomachs) from escaping via the omasal or the intestinal pathway, in turn causing the organ to distend. As the abomasum enlarges, it slides, so that in the case of left-side displacement it will move leftwards, beneath the ruminal atrium and ventral ruminal sac, ultimately rising (like a balloon) between the rumen and the abdominal wall.
In the less common right-side displacement, the accumulation of fluid and gas leads to a caudo-dorsal dilatation. The abomasum then has the potential to twist on the lesser omentum, creating an abomasal volvulus. This can cause acute obstruction with local circulatory impairment and ischaemic necrosis of the abomasal wall leading to a worse prognosis, with mean survival rates of only 61–74% (Constable et al., 1991, Fubini et al., 1991, Meylan, 1999, Sattler et al., 2000). In contrast to left-side displacements, which occur primarily within the first 4 weeks after calving, only 50–70% of right displacements are found in this period, while the rest occur independent of the stage of gestation or lactation (Hof, 1999, Dirksen, 2002).
The majority of studies have focused on factors that predispose to left AD, although the aetiopathogenesis of right AD and abomasal volvulus are thought to be similar (Dirksen, 2002, Trent, 2004). This review will give an overview of the current knowledge of the aetiology and pathogenesis of AD in dairy cows.
Section snippets
Breed, age and milk yield
AD occurs primarily in the classical dairy breeds, such as the Holstein Friesian and German Holstein (Martin et al., 1978, Geishauser et al., 1996, Wolf et al., 2001a, Wolf et al., 2001b) as well as on Simmental–Red-Holstein crossbreeds (Eicher et al., 1999), Brown Swiss, Ayrshires, Guernseys (Constable et al., 1992) and Jerseys (Jubb et al., 1991). In contrast, left AD is still a rare finding in German Fleckvieh cows (lactation incidence 0.15%; Berchtold and Prechtl, 2007), despite an increase
Conclusions
Based on current data, it can be assumed that an inhibition of abomasal motility is the key event in the majority of cases of AD. Most likely this is due to an impaired function of the enteric nervous system in this organ. In addition, the genetic background is an important risk factor for the development of the disease. Thus, inter-individual predispositions within the breeds should be considered when raising cattle. At the present time, cattle farmers should try to avoid all risk factors
Conflict of Interest Statement
None of the authors of this paper has a financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper.
References (93)
- et al.
Dry cow diet, management, and energy balance as risk factors for displaced abomasum in high producing dairy herds
Journal of Dairy Science
(1998) - et al.
Effect of forage-concentrate ratio in complete feeds fed ad libitum on feed intake prepartum and the occurrence of abomasal displacement in dairy cows
Journal of Dairy Science
(1972) - et al.
Effects of left displaced abomasum on test day milk yields of Holstein cows
Journal of Dairy Science
(1997) - et al.
Disease, production and culling in Holstein-Friesian cows. IV. Effects of disease on production
Preventive Veterinary Medicine
(1984) - et al.
Effect of diseases on the culling of Holstein dairy cows in New York State
Journal of Dairy Science
(1998) - et al.
A simple method for the analysis of particle sizes of forage and total mixed rations
Journal of Dairy Science
(1996) - et al.
Metabolic predictors of displaced abomasum in dairy cattle
Journal of Dairy Science
(2005) - et al.
Effect of dietary composition on abomasal and duodenal myoelectrical activity
Research in Veterinary Science
(1994) - et al.
Genetics of health traits in Holstein cattle
Journal of Dairy Science
(1991) - et al.
Effects of hypocalcaemia on abomasal motility
Research in Veterinary Science
(1988)
Health care of Holsteins selected for large or small body size
Journal of Dairy Science
The association of displaced abomasum with various periparturient factors in dairy cows. A retrospective study
Preventive Veterinary Medicine
Concentrate feeding, dry-matter intake, and metabolic disorders in Danish dairy cows
Livestock Production Science
Nutritional risk factors in the etiology of left displacement in dairy cows; a review
Journal of Dairy Science
Metabolic characteristics of induced ketosis in normal and obese dairy cows
Journal of Dairy Science
Genetic parameters for common health disorders of Holstein cows
Journal of Dairy Science
Feed intake, milk yield, and metabolic parameters prior to left displaced abomasum in dairy cows
Journal of Dairy Science
Genetic selection for health traits using producer-recorded data. I. Incidence rates, heritability estimates, and sire breeding values
Journal of Dairy Science
Genetic selection for health traits using producer-recorded data. II. Genetic correlations, disease probability, and relationships with existing traits
Journal of Dairy Science
Changes in blood ionized calcium and some other blood parameters before and after replacement of a left-sided displaced abomasum in dairy cattle
Deutsche Tierärztliche Wochenschrift
Diseases of the stomach of the adult ruminant
Veterinary Record
Vorkommen von Labmagenverlagerung bei Rindern der Rasse Deutsches Fleckvieh und Deutsche Holsteins in einem Praxisgebiet in Oberbayern
Zur Definition physiologischer Leistungsgrenzen
Abomasal displacement in cattle: influence of concentrates in the ration on fatty acid concentrations in ruminal, abomasal, and duodenal contents
American Journal of Veterinary Research
Does the weather influence the occurrence of abomasal displacement in dairy cows?
Deutsche Tierärztliche Wochenschrift
Preoperative prognostic indicators on cattle with abomasal volvulus
Journal of the American Veterinary Medical Association
Risk factors for abomasal volvulus and left abomasal displacement in cattle
American Journal of Veterinary Research
Influence of fiber form in a complete mixed ration on incidence of left displacement abomasum in postpartum dairy cows
Journal of the American Veterinary Medical Association
Die Erweiterung, Verlagerung und Drehung des Labmagens beim Rind
Zentralblatt für Veterinärmedizin
Krankheiten des Labmagens
Epidemiologie und Risikofaktoren der Blinddarmdilatation und Labmagenverlagerung bei der Milchkuh
Schweizer Archiv für Tierheilkunde
Right displacement of the abomasum and abomasal volvulus in dairy cows: 458 cases
Journal of the American Veterinary Medical Association
Körperkondition and Dislocatio abomasi (DA): Vergleichende Untersuchungen zum Verhalten der Rückenfettdicke sowie weiterer Kriterien bei Rindern
Deutsche Tierärztliche Wochenschrift
Schätzung der Erblichkeit von Labmagenverlagerung bei Deutsch-Schwarzbunten Rindern in Hessen
Journal of Veterinary Medicine A
Evaluation of aspartate aminotransferase activity and β-hydroxybutyrate concentration in blood as tests for prediction of left displaced abomasum in dairy cows
American Journal of Veterinary Research
In vitro motility disorders associated with displaced abomasum in dairy cows
Neurogastroenterology and Motility
Neurology of the stomach
Feed composition and left abomasal displacement in dairy cattle A case-control study
Nordisk Veterinärmedizin
Milk production and left displaced abomasum: cause and effect relationships
Nordisk Veterinärmedizin
Processing, mixing, and particle size reduction of forages for dairy cattle
Journal of Animal Science
Effects of intravenous infusion of glucose and pancreatic glucagon on abomasal function in dairy cows
Acta Veterinaria Scandinavica
The effect of the plasma glucose level on the abomasal function in dairy cows
Journal of Animal Science
Risk factors of displaced abomasum in Wisconsin dairy herds
Bovine Practitioner
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