The importance of a human 3D database and atlas for studies of prefrontal and thalamic functions
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2004, Biological PsychiatryCitation Excerpt :Third, statistical parametric map analysis (SPM) describes the results in five stages (from large to small brain areas): left and right cerebrum, lobe, gyrus, gray and white matter, and Brodmann areas. Because of the limited spatial resolution of SPECT imaging and the great variability in brain anatomy between individuals, it is not adequate to describe our results by referring to Brodmann areas (Amunts et al 1999; Uylings et al 2000). To enhance understanding of the underlying neurobiological mechanisms in the pathophysiology of PTSD, it will be important in future studies to compare different functional brain imaging techniques and to use a randomized sequence of scripts in assessing patients with PTSD.
Involvement of serotonin in depression: Evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter
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2002, Biological PsychiatryCitation Excerpt :Although Benes et al (2001) make a plea for 2-D cell-counting methods it is quite obvious that they did not count the profiles in a 2-D plane, but in a 3D probe with a thickness of 4.5 to about 9 μm using a 25× objective (p. 403). The depth of vision of 25× objectives encompasses a large part of the thickness of 20-μm sections, i.e. 4.5 to 9 μm (see Uylings et al 1986). Non-insiders who read Benes et al (2001) might easily get the impression that 3-D cell-counting methods imply the use of too small sampling probes.