Pallidal border cells: an anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey
Section snippets
Animals
Experiments were conducted on 12 female macaque monkeys weighing 3–6 kg, as described below. Animals were housed in individual primate cages under controlled conditions of humidity (50±5%), temperature (24±1°C) and light (12-h/12-h light–dark cycle), food and water were available ad libitum, and their care supervised by veterinarians skilled in the healthcare and maintenance of non-human primates. Experiments were carried out in accordance with the European Communities Council Directive of 24
Assessment of dopaminergic denervation
Three-way ANOVA showed a significant difference for the group (F1,168=6245.3, P<0.0001) and striatal region variables (F7,168=3.7, P<0.001). It also showed no difference for the striatal level (F2,168=1.64), indicating that the dopaminergic denervation is uniform throughout the rostrocaudal extent of the striatum. Whatever the level and the region considered in both the putamen and caudate nucleus of MPTP-treated monkeys, the DAT binding decreased significantly in comparison with that of normal
Discussion
The most significant findings of the present study are that: (i) pallidal dopaminergic innervation, which is mainly restricted to the border cells surrounding the GPi, still persists in the MPTP-lesioned monkey; (ii) MPTP treatment produces a dramatic decrease in border cell firing frequency, but no change in distribution of firing pattern; (iii) levodopa administration to the MPTP-lesioned monkey increases firing frequency and changes the pattern of firing. These data suggest that pallidal
Acknowledgements
E. Bezard was the recipient of an INSERM grant.
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E. Bezard and T. Boraud contributed equally to this work.