Elsevier

Neuroscience

Volume 103, Issue 1, 28 February 2001, Pages 117-123
Neuroscience

Pallidal border cells: an anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey

https://doi.org/10.1016/S0306-4522(00)00546-7Get rights and content

Abstract

A dopamine transporter–radioligand binding study demonstrated a dopaminergic innervation around the pallidal complex in the normal monkey (n=5), i.e. where a subpopulation of pallidal neurons known as “border cells” is classically identified. Surprisingly, this peripallidal binding persists in monkeys rendered parkinsonian (n=5) with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment. The border cell electrophysiological activity was then analysed in normal and parkinsonian monkeys (n=2), either in the untreated state or following administration of levodopa. Pallidal border cell firing frequency was significantly decreased after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment (8.9±0.7 vs 31.4±1.6 Hz, P<0.05). This decrease was partly corrected by levodopa administration (19.2±1.0 Hz, P<0.05 vs both normal and parkinsonian situations).

The peripallidal dopaminergic innervation suggests that pallidal border cells are under a direct dopaminergic control, arising from the ventral tegmental area and/or the basal forebrain magnocellular complex, the role of which remains unknown. Moreover, the relative sparing of these dopaminergic fibers in parkinsonian monkeys suggests that they would exhibit specific adaptive properties totally different from those described in the nigrostriatal pathway.

Section snippets

Animals

Experiments were conducted on 12 female macaque monkeys weighing 3–6 kg, as described below. Animals were housed in individual primate cages under controlled conditions of humidity (50±5%), temperature (24±1°C) and light (12-h/12-h light–dark cycle), food and water were available ad libitum, and their care supervised by veterinarians skilled in the healthcare and maintenance of non-human primates. Experiments were carried out in accordance with the European Communities Council Directive of 24

Assessment of dopaminergic denervation

Three-way ANOVA showed a significant difference for the group (F1,168=6245.3, P<0.0001) and striatal region variables (F7,168=3.7, P<0.001). It also showed no difference for the striatal level (F2,168=1.64), indicating that the dopaminergic denervation is uniform throughout the rostrocaudal extent of the striatum. Whatever the level and the region considered in both the putamen and caudate nucleus of MPTP-treated monkeys, the DAT binding decreased significantly in comparison with that of normal

Discussion

The most significant findings of the present study are that: (i) pallidal dopaminergic innervation, which is mainly restricted to the border cells surrounding the GPi, still persists in the MPTP-lesioned monkey; (ii) MPTP treatment produces a dramatic decrease in border cell firing frequency, but no change in distribution of firing pattern; (iii) levodopa administration to the MPTP-lesioned monkey increases firing frequency and changes the pattern of firing. These data suggest that pallidal

Acknowledgements

E. Bezard was the recipient of an INSERM grant.

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    E. Bezard and T. Boraud contributed equally to this work.

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