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Detection of antibodies against Fasciola hepatica in cirrhotic patients from Peru

Published online by Cambridge University Press:  01 March 2009

L.A. Marcos ,
A. Bussalleu ,
A. Terashima  and
J.R. Espinoza
L.A. Marcos*
Affiliation:
Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru Department of Internal Medicine, University of Texas Health Science, Houston, TX, USA
A. Bussalleu
Affiliation:
Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru
A. Terashima
Affiliation:
Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru
J.R. Espinoza
Affiliation:
Laboratorios de Investigación y Desarrollo (LID), Facultad de Ciencias y Filosofía ‘Alberto Cazorla Talleri’, Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru
*
*E-mail: Luis.A.Marcos@uth.tmc.edu
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Abstract

The prevalence of Fasciola hepatica infection, in endemic countries, in patients with established cirrhosis is unknown. We hypothesized that, in endemic countries, the presence of fascioliasis may be detected in a serum pool of cirrhotic patients. Forty-four previously stored serum samples of patients with established liver cirrhosis, in the Hospital Nacional Cayetano Heredia in Lima, Peru, were collected from 1998 to 2003 and assessed for hepatitis B, C and fascioliasis antibodies (Fas2 ELISA). Hepatitis B surface antigen (HBsAg) was positive in 8.8% (n = 34), hepatitis B core antibody (anti-HBc) in 32.5% (n = 34), hepatitis C antibodies (anti-HCV) in 9.1% (n = 33), and 9.1% (n = 44) were Fas2 ELISA positive. This disease is an example of an emerging tropical infection which can be present in chronic liver diseases, requiring greater clinician awareness especially in endemic rural areas. Further clinical studies are warranted.

Type
Research Note
Information
Journal of Helminthology , Volume 83 , Issue 1 , March 2009 , pp. 23 - 26
Copyright
Copyright © Cambridge University Press 2009

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