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PIWIL1 protein power targets tau therapy

Nature Neuroscience volume 17, pages 334–335 (2014)Cite this article

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A study now suggests that tau-induced reactive oxygen species relax chromatin, which leads to expression of PIWIL1, cell cycle reentry and neurodegeneration.

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Figure 1: Tau leads to neurodegeneration via heterochromatin relaxation and PIWIL1 expression.

Katie Vicari

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Authors and Affiliations

  1. Department of Human Genetics, Sandra-Fausia Soukup and Patrik Verstreken are at the VIB, Center for the Biology of Disease, University Leuven (KU Leuven), Leuven, Belgium.,

    Sandra-Fausia Soukup & Patrik Verstreken

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  1. Sandra-Fausia Soukup
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  2. Patrik Verstreken
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Correspondence to Patrik Verstreken.

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The authors declare no competing financial interests.

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Soukup, SF., Verstreken, P. PIWIL1 protein power targets tau therapy. Nat Neurosci 17, 334–335 (2014). https://doi.org/10.1038/nn.3659

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