Nature 572, 397–401 (2019)

Diets restricted in methionine increase therapeutic response in therapy-resistant cancers in mice.

Tumor metabolism is known to be altered compared with that in normal tissue, and thus far this reliance on altered metabolic pathways is a somewhat untapped resource for cancer therapy development.

Jason Locasale and his colleagues found that mice fed a methonione-restricted diet had altered tumor metabolism such that patient-derived xenografted and autochthonous tumors were more susceptible to chemotherapy and radiation. The metabolic changes were echoed in healthy humans fed a similar diet.