Nature 572, 397–401 (2019)
Diets restricted in methionine increase therapeutic response in therapy-resistant cancers in mice.
Tumor metabolism is known to be altered compared with that in normal tissue, and thus far this reliance on altered metabolic pathways is a somewhat untapped resource for cancer therapy development.
Jason Locasale and his colleagues found that mice fed a methonione-restricted diet had altered tumor metabolism such that patient-derived xenografted and autochthonous tumors were more susceptible to chemotherapy and radiation. The metabolic changes were echoed in healthy humans fed a similar diet.
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Stower, H. Diet influence on cancer therapy. Nat Med 25, 1330 (2019). https://doi.org/10.1038/s41591-019-0588-y
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DOI: https://doi.org/10.1038/s41591-019-0588-y