New Results
Top-down control of water intake by the endocannabinoid system
View ORCID ProfileZhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano
doi: https://doi.org/10.1101/729970
Zhe Zhao
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Edgar Soria-Gómez
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
3IKERBASQUE Basque Foundation for Science, University of the Basque Country UPV/EHU, Achucarro Basque Center for Neuroscience
Marjorie Varilh
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Francisca Julio-Kalajzić
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Astrid Cannich
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Adriana Castiglione
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Léonie Vanhoutte
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Alexia Duveau
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Philippe Zizzari
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Anna Beyeler
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Daniela Cota
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Luigi Bellocchio
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Arnau Busquets-Garcia
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
4Integrative Pharmacology and Systems Neuroscience, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain
Giovanni Marsicano
1INSERM, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
2University of Bordeaux, NeuroCentre Magendie, Physiopathologie de la Plasticité Neuronale U1215, F33077 Bordeaux, France
Abstract
Water intake is regulated by neocortical top-down circuits, but their identity and the cellular mechanisms involved are scantly known. Here, we show that endogenous activation of type-1 cannabinoid receptors (CB1) promotes water intake and that endocannabinoid modulation of excitatory projections from the anterior cingulate cortex to the basolateral amygdala is sufficient to guarantee physiological drinking. These data reveal a new circuit involved in the homeostatic control of water intake.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted August 09, 2019.
Top-down control of water intake by the endocannabinoid system
Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano
bioRxiv 729970; doi: https://doi.org/10.1101/729970
Top-down control of water intake by the endocannabinoid system
Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano
bioRxiv 729970; doi: https://doi.org/10.1101/729970
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