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From hindbrain segmentation to breathing after birth

Developmental patterning in rhombomeres 3 and 4

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Abstract

Respiration is a rhythmic motor behavior that appears in the fetus and acquires a vital importance at birth. It is generated within central pattern-generating neuronal networks of the hindbrain. This region of the brain is of particular interest since it is the most understood part with respect to the cellular and molecular mechanisms that underlie its development. Hox paralogs and Hox-regulating genes kreisler/mafB and Krox20 are required for the normal formation of rhombomeres in vertebrate embryos. From studies of rhombomeres r3 and r4, the authors review mechanisms whereby these developmental genes may govern the early embryonic development of para-facial neuronal networks and specify patterns of motor activities operating throughout life. A model whereby the regional identity of progenitor cells can be abnormally specified in r3 and r4 after a mutation of these genes is proposed. Novel neuronal circuits may develop from some of these misspecified progenitors while others are eliminated, eventually affecting respiration and survival after birth.

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Authors and Affiliations

  1. UPR 2216 Neurobiologie Génétique et Intégrative, Institut de Neurobiologie Alfred Fessard, CNRS, 1, av. de la Terrasse, 91198, Gif-sur-Yvette, France

    Fabrice Chatonnet, Muriel Thoby-Brisson, Jean Champagnat, Gilles Fortin & Christelle Thaëron-Antôno

  2. División Neurociencias, Laboratorio Andaluz de Biología, Universidad Pablo de Olavide, Ctra. de Utrera Km1, 41013, Sevilla, Spain

    Eduardo Domínguez del Toro

  3. Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 10142 -67404, Illkirch Cedex, CU de Strasbourg, France

    Filippo M. Rijli

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  1. Fabrice Chatonnet
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  2. Eduardo Domínguez del Toro
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Chatonnet, F., del Toro, E.D., Thoby-Brisson, M. et al. From hindbrain segmentation to breathing after birth. Mol Neurobiol 28, 277–293 (2003). https://doi.org/10.1385/MN:28:3:277

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