Open Access
Research
(Published
online: 16-12-2016)
15.
Intravenous administration of puppy
deciduous teeth stem cells in degenerative valve disease -
Soontaree Petchdee and Sarunya Sompeewong
Veterinary World, 9(12): 1429-1434
doi:
10.14202/vetworld.2016.1429-1434
Soontaree Petchdee:
Department of Large Animal and Wildlife Clinical Science,
Faculty of Veterinary Medicine, Kasetsart University,
Kamphaengsaen, Nakhorn Pathom 73140, Thailand; fvetstr@ku.ac.th
Sarunya Sompeewong:
Kasetsart University, Veterinary Teaching Animal Hospital,
Kamphaeng Saen, Thailand; lksarunya@gmail.com
Received: 23-07-2016, Accepted: 16-11-2016, Published online:
16-12-2016
Corresponding author:
Soontaree Petchdee, e-mail: fvetstr@ku.ac.th
Citation:
Petchdee S, Sompeewong S (2016) Intravenous administration of
puppy deciduous teeth stem cells in degenerative valve disease,
Veterinary World, 9(12):
1429-1434.
Abstract
Aim:
The objective of this study is to investigate the improvement of
heart function in dogs with chronic valvular heart disease after
puppy deciduous teeth stem cells (pDSCs) administration.
Materials and Methods:
20 client-owned dogs with degenerative valvular heart disease
underwent multiple intravenous injections of allogeneic pDSCs.
Dogs were randomly assigned to two groups: (i) Control group
(n=10) with standard treatment for heart failure and (ii) group
with standard treatment and multiple administrations of pDSCs
(n=10). Electrocardiography, complete transthoracic
echocardiography, thoracic radiography, and blood pressure were
recorded before and after pDSCs injections for 15, 30 and 60 days.
Results:
Post pDSCs injection showed measurable improvement in left
ventricular ejection fraction, American College of Veterinary
Internal Medicine (ACVIM) functional class significantly improved
and improved quality of life scores were observed. In the control
group, there were no significant enhancements in heart function or
ACVIM class.
Conclusions:
This finding suggests that pDSCs could be a supplement for
valvular heart disease treatment.
Keywords:
dental pulp stem cells, dogs, heart failure.
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