5-HT₆ receptor antagonists as treatment for age-related cognitive decline

References

Ahlander, M., Misane, I., Schött, P.A., and Ogren, S.O. (1999). A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat. Neuropsychopharmacology 21, 414–426.10.1016/S0893-133X(98)00116-XSearch in Google Scholar

Ansanay, H., Dumuis, A., Sebben, M., Bockaert, J., and Fagni, L. (1995). cAMP-dependent, long-lasting inhibition of a K+ current in mammalian neurons. Proc. Natl. Acad. Sci. USA 92, 6635–6639.10.1073/pnas.92.14.6635Search in Google Scholar

Balmanno, K. and Cook, S.J. (2009). Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ. 16, 368–377.10.1038/cdd.2008.148Search in Google Scholar

Bartus, R.T. (2000). On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 163, 495–529.10.1006/exnr.2000.7397Search in Google Scholar

Bartus, R.T., Dean, R.L., 3rd, Beer, B., and Lippa, A.S. (1982). The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408–414.10.1126/science.7046051Search in Google Scholar

Bekinschtein, P., Cammarota, M., Katche, C., Slipczuk, L., Rossato, J.I., Goldin, A., Izquierdo, I., and Medina, J.H. (2008). BDNF is essential to promote persistence of long-term memory storage. Proc. Natl. Acad. Sci. USA 105, 2711–2716.10.1073/pnas.0711863105Search in Google Scholar

Bezprozvanny, I. (2010). The rise and fall of Dimebon. Drug News Perspect. 23, 518–523.10.1358/dnp.2010.23.8.1500435Search in Google Scholar

Bhaskar, K., Yen, S.-H., and Lee, G. (2005). Disease-related modifications in tau affect the interaction between Fyn and Tau. J. Biol. Chem. 280, 35119–35125.10.1074/jbc.M505895200Search in Google Scholar

Birks, J. (2006). Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database Syst. Rev. (1), Art. No.: CD005593. DOI: 10.1002/14651858.CD005593.10.1002/14651858.CD005593Search in Google Scholar

Bös, M., Sleight, A.J., Godel, T., Martin, J.R., Riemer, C., and Stadler, H. (2001). 5-HT(6) receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides. Eur. J. Med. Chem. 36, 165–178.10.1016/S0223-5234(00)01209-5Search in Google Scholar

Bourson, A., Borroni, E., Austin, R.H., Monsma, F.J., Jr, and Sleight, A.J. (1995). Determination of the role of the 5-HT6 receptor in the rat brain: a study using antisense oligonucleotides. J. Pharmacol. Exp. Ther. 274, 173–180.Search in Google Scholar

Callaghan, C.K., Hok, V., Della-Chiesa, A., Virley, D.J., Upton, N., and O’Mara, S.M. (2012). Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology 63, 890–897.10.1016/j.neuropharm.2012.06.034Search in Google Scholar

Codony, X., Vela, J.M., and Ramírez, M.J. (2011). 5-HT(6) receptor and cognition. Curr. Opin. Pharmacol. 11, 94–100.10.1016/j.coph.2011.01.004Search in Google Scholar

Csernansky, J.G., Martin, M., Shah, R., Bertchume, A., Colvin, J., and Dong, H. (2005). Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice. Neuropsychopharmacology 30, 2135–2143.10.1038/sj.npp.1300761Search in Google Scholar

Da Silva Costa, V., Duchatelle, P., Boulouard, M., and Dauphin, F. (2009). Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse. Neuropsychopharmacology 34, 488–500.10.1038/npp.2008.94Search in Google Scholar

Da Silva Costa-Aze, V., Dauphin, F., and Boulouard, M. (2011). Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice. Behav. Brain Res. 222, 134–140.10.1016/j.bbr.2011.03.046Search in Google Scholar

Da Silva Costa-Aze, V., Quiedeville, A., Boulouard, M., and Dauphin, F. (2012). 5-HT6 receptor blockade differentially affects scopolamine-induced deficits of working memory, recognition memory and aversive learning in mice. Psychopharmacology 222, 99–115.10.1007/s00213-011-2627-3Search in Google Scholar

Dawson, L.A., Nguyen, H.Q., and Li, P. (2000). In vivo effects of the 5-HT(6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate. Br. J. Pharmacol. 130, 23–26.10.1038/sj.bjp.0703288Search in Google Scholar

Dawson, L.A., Nguyen, H.Q., and Li, P. (2001). The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 25, 662–668.10.1016/S0893-133X(01)00265-2Search in Google Scholar

De Bruin, N.M.W.J., Prickaerts, J., van Loevezijn, A., Venhorst, J., de Groote, L., Houba, P., Reneerkens, O., Akkerman, S., and Kruse, C.G. (2011). Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats. Neurobiol. Learn. Mem. 96, 392–402.10.1016/j.nlm.2011.06.015Search in Google Scholar PubMed

De Foubert, G., Khundakar, A.A., and Zetterström, T.S. (2013). Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival. Neurosci. Lett. 553, 211–215.10.1016/j.neulet.2013.08.029Search in Google Scholar PubMed

Foley, A.G., Murphy, K.J., Hirst, W.D., Gallagher, H.C., Hagan, J.J., Upton, N., Walsh, F.S., and Regan, C.M. (2004). The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology 29, 93–100.10.1038/sj.npp.1300332Search in Google Scholar

Foley, A.G., Hirst, W.D., Gallagher, H.C., Barry, C., Hagan, J.J., Upton, N., Walsh, F.S., Hunter, A.J., and Regan, C.M. (2008). The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54, 1166–1174.10.1016/j.neuropharm.2008.03.012Search in Google Scholar

Fone, K.C.F. (2008). An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology 55, 1015–1022.10.1016/j.neuropharm.2008.06.061Search in Google Scholar

Gallagher, M., Stocker, A.M., and Koh, M.T. (2011). Mindspan: lessons from rat models of neurocognitive aging. ILAR J. 52, 32–40.10.1093/ilar.52.1.32Search in Google Scholar

Gandy, S. and DeKosky, S.T. (2013). Toward the treatment and prevention of Alzheimer’s disease: rational strategies and recent progress. Annu. Rev. Med. 64, 367–383.10.1146/annurev-med-092611-084441Search in Google Scholar

Garcia-Alloza, M., Hirst, W.D., Chen, C.P.L.-H., Lasheras, B., Francis, P.T., and Ramírez, M.J. (2004). Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer’s disease. Neuropsychopharmacology 29, 410–416.10.1038/sj.npp.1300330Search in Google Scholar

Gérard, C., el Mestikawy, S., Lebrand, C., Adrien, J., Ruat, M., Traiffort, E., Hamon, M., and Martres, M.P. (1996). Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. Synapse 23, 164–173.10.1002/(SICI)1098-2396(199607)23:3<164::AID-SYN5>3.0.CO;2-6Search in Google Scholar

Gower, A.J. and Lamberty, Y. (1993). The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice. Behav. Brain Res. 57, 163–173.10.1016/0166-4328(93)90132-ASearch in Google Scholar

Gravius, A., Laszy, J., Pietraszek, M., Sághy, K., Nagel, J., Chambon, C., Wegener, N., Valastro, B., Danysz, W., and Gyertyán, I. (2011). Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity. Behav. Pharmacol. 22, 122–135.10.1097/FBP.0b013e328343d804Search in Google Scholar

Hasselmo, M.E. and McGaughy, J. (2004). High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation. Prog. Brain Res. 145, 207–231.10.1016/S0079-6123(03)45015-2Search in Google Scholar

Hirst, W.D., Abrahamsen, B., Blaney, F.E., Calver, A.R., Aloj, L., Price, G.W., and Medhurst, A.D. (2003). Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol. Pharmacol. 64, 1295–1308.10.1124/mol.64.6.1295Search in Google Scholar

Hirst, W.D., Stean, T.O., Rogers, D.C., Sunter, D., Pugh, P., Moss, S.F., Bromidge, S.M., Riley, G., Smith, D.R., Bartlett, S., et al. (2006). SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur. J. Pharmacol. 553, 109–119.10.1016/j.ejphar.2006.09.049Search in Google Scholar

Ivachtchenko, A.V. and Ivanenkov, Y.A. (2012). 5HT(6) receptor antagonists: a patent update. Part 1. Sulfonyl derivatives. Expert Opin. Ther. Pat. 22, 917–964.10.1517/13543776.2012.709236Search in Google Scholar

Kendall, I., Slotten, H.A., Codony, X., Burgueño, J., Pauwels, P.J., Vela, J.M., and Fone, K.C.F. (2011). E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat. Psychopharmacology (Berl.) 213, 413–430.10.1007/s00213-010-1854-3Search in Google Scholar

King, M.V., Sleight, A.J., Woolley, M.L., Topham, I.A., Marsden, C.A., and Fone, K.C.F. (2004). 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation – an effect sensitive to NMDA receptor antagonism. Neuropharmacology 47, 195–204.10.1016/j.neuropharm.2004.03.012Search in Google Scholar

Kinsey, A.M., Wainwright, A., Heavens, R., Sirinathsinghji, D.J., and Oliver, K.R. (2001). Distribution of 5-HT(5A), 5-HT(5B), 5-HT(6) and 5-HT(7) receptor mRNAs in the rat brain. Brain Res. Mol. Brain Res. 88, 194–198.10.1016/S0169-328X(01)00034-1Search in Google Scholar

Klinkenberg, I. and Blokland, A. (2010). The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci. Biobehav. Rev. 34, 1307–1350.10.1016/j.neubiorev.2010.04.001Search in Google Scholar

Kohen, R., Metcalf, M.A., Khan, N., Druck, T., Huebner, K., Lachowicz, J.E., Meltzer, H.Y., Sibley, D.R., Roth, B.L., and Hamblin, M.W. (1996). Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. J. Neurochem. 66, 47–56.10.1046/j.1471-4159.1996.66010047.xSearch in Google Scholar

Kohen, R., Fashingbauer, L.A., Heidmann, D.E., Guthrie, C.R., and Hamblin, M.W. (2001). Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop. Brain Res. Mol. Brain Res. 90, 110–117.10.1016/S0169-328X(01)00090-0Search in Google Scholar

Lezoualc’h, F. and Robert, S.J. (2003). The serotonin 5-HT4 receptor and the amyloid precursor protein processing. Exp. Gerontol. 38, 159–166.10.1016/S0531-5565(02)00157-2Search in Google Scholar

Lieben, C.K.J., Blokland, A., Sik, A., Sung, E., van Nieuwenhuizen, P., and Schreiber, R. (2005). The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology 30, 2169–2179.10.1038/sj.npp.1300777Search in Google Scholar PubMed

Lindner, M.D., Hodges, D.B., Jr, Hogan, J.B., Orie, A.F., Corsa, J.A., Barten, D.M., Polson, C., Robertson, B.J., Guss, V.L., Gillman, K.W., et al. (2003). An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning. J. Pharmacol. Exp. Ther. 307, 682–691.10.1124/jpet.103.056002Search in Google Scholar PubMed

Loiseau, F., Dekeyne, A., and Millan, M.J. (2008). Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex. Psychopharmacology (Berl.) 196, 93–104.10.1007/s00213-007-0934-5Search in Google Scholar PubMed

Lorke, D.E., Lu, G., Cho, E., and Yew, D.T. (2006). Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. BMC Neurosci. 7, 36.10.1186/1471-2202-7-36Search in Google Scholar PubMed PubMed Central

Maher-Edwards, G., Dixon, R., Hunter, J., Gold, M., Hopton, G., Jacobs, G., Hunter, J., and Williams, P. (2011). SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study. Int. J. Geriatr. Psychiatry 26, 536–544.10.1002/gps.2562Search in Google Scholar PubMed

Marcos, B., Gil-Bea, F.J., Hirst, W.D., García-Alloza, M., and Ramírez, M.J. (2006). Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. Eur. J. Neurosci. 24, 1299–1306.10.1111/j.1460-9568.2006.05003.xSearch in Google Scholar PubMed

Marcos, B., Chuang, T.T., Gil-Bea, F.J., and Ramirez, M.J. (2008a). Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat. Br. J. Pharmacol. 155, 434–440.10.1038/bjp.2008.281Search in Google Scholar PubMed PubMed Central

Marcos, B., García-Alloza, M., Gil-Bea, F.J., Chuang, T.T., Francis, P.T., Chen, C.P., Tsang, S.W.T.Y., Lai, M.K.P., and Ramírez, M.J. (2008b). Involvement of an altered 5-HT-{6} receptor function in behavioral symptoms of Alzheimer’s disease. J. Alzheimers Dis. 14, 43–50.10.3233/JAD-2008-14104Search in Google Scholar

Martin, S.J., Grimwood, P.D., and Morris, R.G. (2000). Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23, 649–711.10.1146/annurev.neuro.23.1.649Search in Google Scholar PubMed

McShane, R., Areosa Sastre, A., and Minakaran, N. (2006). Memantine for dementia. Cochrane Database Syst. Rev. (2), Art. No.: CD003154. DOI: 10.1002/14651858.CD003154.pub5.10.1002/14651858.CD003154.pub5Search in Google Scholar PubMed

Mebratu, Y. and Tesfaigzi, Y. (2009). How ERK1/2 activation controls cell proliferation and cell death: is subcellular localization the answer? Cell Cycle 8, 1168–1175.10.4161/cc.8.8.8147Search in Google Scholar

Meffre, J., Chaumont-Dubel, S., Mannoury la Cour, C., Loiseau, F., Watson, D.J.G., Dekeyne, A., Séveno, M., Rivet, J.-M., Gaven, F., Déléris, P., et al. (2012). 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. EMBO Mol. Med. 4, 1043–1056.10.1002/emmm.201201410Search in Google Scholar

Meneses, A. (2001). Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation. Behav. Brain Res. 118, 107–110.10.1016/S0166-4328(00)00316-8Search in Google Scholar

Meneses, A., Manuel-Apolinar, L., Castillo, C., and Castillo, E. (2007). Memory consolidation and amnesia modify 5-HT6 receptors expression in rat brain: an autoradiographic study. Behav. Brain Res. 178, 53–61.10.1016/j.bbr.2006.11.048Search in Google Scholar PubMed

Mitchell, E.S., Hoplight, B.J., Lear, S.P., and Neumaier, J.F. (2006). BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50, 412–420.10.1016/j.neuropharm.2005.10.002Search in Google Scholar PubMed

Mitchell, E.S., McDevitt, R.A., and Neumaier, J.F. (2009). Adaptations in 5-HT receptor expression and function: implications for treatment of cognitive impairment in aging. J. Neurosci. Res. 87, 2803–2811.10.1002/jnr.22100Search in Google Scholar PubMed

Monsma, F.J., Jr, Shen, Y., Ward, R.P., Hamblin, M.W., and Sibley, D.R. (1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol. 43, 320–327.Search in Google Scholar

Mora, F. (2013). Successful brain aging: plasticity, environmental enrichment, and lifestyle. Dialogues Clin. Neurosci. 15, 45–52.10.31887/DCNS.2013.15.1/fmoraSearch in Google Scholar

Neugroschl, J., Sano, M. (2010). Current treatment and recent clinical research in Alzheimer’s disease. MT Sinai J. Med. 77, 3–16.10.1002/msj.20165Search in Google Scholar PubMed PubMed Central

Oono, K., Yoneda, T., Manabe, T., Yamagishi, S., Matsuda, S., Hitomi, J., Miyata, S., Mizuno, T., Imaizumi, K., Katayama, T., et al. (2004). JAB1 participates in unfolded protein responses by association and dissociation with IRE1. Neurochem. Int. 45, 765–772.10.1016/j.neuint.2004.01.003Search in Google Scholar PubMed

Perez-García, G. and Meneses, A. (2005). Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacol. Biochem. Behav. 81, 673–682.10.1016/j.pbb.2005.05.005Search in Google Scholar PubMed

Riemer, C., Borroni, E., Levet-Trafit, B., Martin, J.R., Poli, S., Porter, R.H.P., and Bös, M. (2003). Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. J. Med. Chem. 46, 1273–1276.10.1021/jm021085cSearch in Google Scholar

Roberson, E.D., Halabisky, B., Yoo, J.W., Yao, J., Chin, J., Yan, F., Wu, T., Hamto, P., Devidze, N., Yu, G.-Q., et al. (2011). Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease. J. Neurosci. 31, 700–711.10.1523/JNEUROSCI.4152-10.2011Search in Google Scholar

Ruat, M., Traiffort, E., Arrang, J.M., Tardivel-Lacombe, J., Diaz, J., Leurs, R., and Schwartz, J.C. (1993). A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Biochem. Biophys. Res. Commun. 193, 268–276.10.1006/bbrc.1993.1619Search in Google Scholar

Schreiber, R., Vivian, J., Hedley, L., Szczepanski, K., Secchi, R.L., Zuzow, M., van Laarhoven, S., Moreau, J.-L., Martin, J.R., Sik, A., et al. (2007). Effects of the novel 5-HT(6) receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating. Eur. Neuropsychopharmacol. 17, 277–288.10.1016/j.euroneuro.2006.06.009Search in Google Scholar

Selkoe, D.J. (2002). Alzheimer′s disease is a synaptic failure. Science 298, 789–791.10.1126/science.1074069Search in Google Scholar

Shirazi-Southall, S., Rodriguez, D.E., and Nomikos, G.G. (2002). Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology 26, 583–594.10.1016/S0893-133X(01)00400-6Search in Google Scholar

Ska, B. and Joanette, Y. (2006). Normal aging and cognition. Med. Sci. (Paris) 22, 284–287.10.1051/medsci/2006223284Search in Google Scholar

Tassone, A., Madeo, G., Sciamanna, G., Pisani, A., and Bonsi, P. (2010). Electrophysiology of 5-HT6 receptors. Int. Rev. Neurobiol. 94, 111–128.10.1016/B978-0-12-384976-2.00005-8Search in Google Scholar

Van der Staay, F.J. (2006). Animal models of behavioral dysfunctions: basic concepts and classifications, and an evaluation strategy. Brain Res. Rev. 52, 131–159.10.1016/j.brainresrev.2006.01.006Search in Google Scholar

Ward, R.P. and Dorsa, D.M. (1996). Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum. J. Comp. Neurol. 370, 405–414.10.1002/(SICI)1096-9861(19960701)370:3<405::AID-CNE10>3.0.CO;2-RSearch in Google Scholar

West, P.J., Marcy, V.R., Marino, M.J., and Schaffhauser, H. (2009). Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience 164, 692–701.10.1016/j.neuroscience.2009.07.061Search in Google Scholar PubMed

Woods, S., Clarke, N.N., Layfield, R., and Fone, K.C.F. (2012). 5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms. Br. J. Pharmacol. 167, 436–449.10.1111/j.1476-5381.2012.02022.xSearch in Google Scholar PubMed PubMed Central

Woolley, M.L., Marsden, C.A., Sleight, A.J., and Fone, K.C.F. (2003). Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berl.) 170, 358–367.10.1007/s00213-003-1552-5Search in Google Scholar PubMed

Yoshioka, M., Matsumoto, M., Togashi, H., and Mori, K. (1998). Central distribution and function of 5-HT6 receptor subtype in the rat brain. Ann. NY Acad. Sci. 861, 244.10.1111/j.1749-6632.1998.tb10201.xSearch in Google Scholar PubMed

Yun, H.-M. and Rhim, H. (2011). The serotonin-6 receptor as a novel therapeutic target. Exp. Neurobiol. 20, 159–168.10.5607/en.2011.20.4.159Search in Google Scholar PubMed PubMed Central

Yun, H.-M., Kim, S., Kim, H.-J., Kostenis, E., Kim, J.I., Seong, J.Y., Baik, J.-H., and Rhim, H. (2007). The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn. J. Biol. Chem. 282, 5496–5505.10.1074/jbc.M606215200Search in Google Scholar PubMed

Yun, H.-M., Baik, J.-H., Kang, I., Jin, C., and Rhim, H. (2010). Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. J. Biol. Chem. 285, 10016–10029.10.1074/jbc.M109.068759Search in Google Scholar PubMed PubMed Central

Zhang, M.-Y., Hughes, Z.A., Kerns, E.H., Lin, Q., and Beyer, C.E. (2007). Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples. J. Pharm. Biomed. Anal. 44, 586–593.10.1016/j.jpba.2007.02.024Search in Google Scholar PubMed