Vet Med - Czech, 2013, 58(10):516-526 | DOI: 10.17221/7083-VETMED

A review on Schmallenberg virus infection: a newly emerging disease of cattle, sheep and goatsReview

R.V.S. Pawaiya, V.K. Gupta
Central Institute for Research on Goats, Makhdoom, Mathura, U.P., India

Schmallenberg virus (SBV) infection is an emerging infectious disease of ruminants first described in Germany in November, 2011. Since then it has spread very rapidly to several European countries. The disease is characterised by fever, reduced milk production and diarrhoea in cattle and abortions, stillbirths and foetal abnormalities in sheep and goats. SBV is an enveloped, negative-sense, segmented, single-stranded RNA virus, classified in the genus Orthobunyavirus of the Bunyaviridae family, and is closely related to Akabane, Ainoa and Shamonda viruses. As of now there is no vaccine available for SBV, which poses a serious threat to naive ruminant population. Owing to its recent discovery, our understanding of Schmallenberg viral disease and its pathology and pathogenesis is limited. This article reviews the data reported so far on this emerging disease with regard to aetiology, epidemiology, pathogenesis, pathology, diagnosis and control and discusses the future scenario and implications of the disease.

Keywords: abortion; congenital malformation; emerging infection; pathology; pathogenesis; ruminants; Schmallenberg virus; stillbirths

Published: October 31, 2013  Show citation

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Pawaiya RVS, Gupta VK. A review on Schmallenberg virus infection: a newly emerging disease of cattle, sheep and goats. Vet Med-Czech. 2013;58(10):516-526. doi: 10.17221/7083-VETMED.
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    References

    1. AHVLA (2013): Schmallenberg virus, updated testing results 24 April 2013. Available at: http://www.defra.gov.uk/ahvla-en/files/20130424sbv-statistics.pdf. Accessed 10 May, 2013.
    2. Azkur AK, Albayrak H, Risvanli A, Pestil Z, Ozan E, Yilmaz O, Tonbak S, Cavunt A, Kadi H, Macun HC, Acar D, Ozenc E, Alparslan S, Bulut H (2013): Antibodies to Schmallenberg virus in domestic livestock in Turkey. Tropical Animal Health Production. doi 10.1007/s11250-013-0415-2. Go to original source... Go to PubMed...
    3. Bauer B, Jandowsky A, Schein E, Mehlitz D, Clausen P-H (2009): An appraisal of current and new techniques intended to protect bulls against Culicoides and other haematophagous Nematocera: the case of Schmergow, Brandenburg, Germany. Parasitology Research 105, 359-365. Go to original source... Go to PubMed...
    4. Bilk S, Schulze C, Fischer M, Beer M, Hlinak A, Hoffmann B (2012): Organ distribution of Schmallenberg virus RNA in malformed newborns. Veterinary Microbiology 159, 236-238. Go to original source... Go to PubMed...
    5. Blakqori G, Delhaye S, Habjan M, Blair CD, SanchezVargas I, Olson KE, Attarzadeh-Yazdi G, Fragkoudis R, Kohl A, Kalinke U, Weiss S, Michiels T, Staeheli P, Weber F (2007): La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. Journal of Virology 81, 4991-4999. Go to original source... Go to PubMed...
    6. Bouloy M, Janzen C, Vialat P, Khun H, Pavlovic J, Huerre M, Haller O (2001): Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs. Journal of Virology 75, 1371-1377. Go to original source... Go to PubMed...
    7. Bowen MD, Trappier SG, Sanchez AJ, Meyer RF, Goldsmith CS, Zaki SR, Dunster LM, Peters CJ, Ksiazek TG, Nichol ST, Task Force RVF (2001): A reassortant bunyavirus isolated from acute hemorrhagic fever cases in Kenya and Somalia. Virology 291, 185-190. Go to original source... Go to PubMed...
    8. Breard E, Lara E, Comtet L, Viarouge C, Doceul V, Desprat A, Vitour D, Pozzi N, Cay AB, De Regge N, Pourquier P, Schirrmeier H, Hoffmann B, Beer M, Sailleau C, Zientara S (2013): Validation of a Commercially Available Indirect Elisa Using a Nucleocapside Recombinant Protein for Detection of Schmallenberg Virus Antibodies. PLoS ONE 8, e53446. doi:10.1371/journal.pone.0053446. Go to original source... Go to PubMed...
    9. Calisher CH (1996): History, classification, and taxonomy of viruses in the family Bunyaviridae. In: Elliott RM (ed) The Bunyaviridae. Plenum Press, New York. 1-17. Go to original source...
    10. Carpenter S (2012): Role of Culicoides biting midges in the transmission of Schmallenberg virus (Abstract). In: The Proceedings of Epizone, 6th Annual Meeting Satellite Symposium on the topic 'Schmallenberg virus', 15th June 2012, Brighton, UK.
    11. Carpenter S, Mellor PS, Torr SJ (2008): Control techniques for Culicoides biting midges and their application in the UK and northwestern Palaearctic. Medical and Veterinary Entomology 22, 175-187. Go to original source... Go to PubMed...
    12. Conraths F, Staubach C, Sonnenburg J, Fröhlich A, Kramer M, Gall Y, Probst C, Horeth-Bontgen D, Teske K, Kamer D, Beer M (2012): Epidemiology of Schmallenberg Virus Infections in Germany (Abstract). In: The Proceedings of Epizone, 6th Annual Meeting Satellite Symposium on the topic 'Schmallenberg virus', 15th June 2012, Brighton, UK. Go to original source...
    13. Conraths F, Peters M, Beer M (2013): Schmallenberg virus, a novel orthobunyavirus infection in ruminants in Europe: Potential global impact and preventive measures. New Zealand Veterinary Journal 61, 63-67. Go to original source... Go to PubMed...
    14. De Regge N, Deblauwe I, De Deken R, Vantieghem P, Madder M, Geysen D, Smeets F, Losson B, van den Berg T, Cay AB (2012): Detection of Schmallenberg virus in different Culicoides spp. by real-time RT-PCR. Transboundary Emerging Diseases 59, 471-475. Go to original source... Go to PubMed...
    15. De Regge N, van den Berg T, Georges L, Cay B (2013): Diagnosis of Schmallenberg virus infection in malformed lambs and calves and first indications for virus clearance in the fetus. Veterinary Microbiology 162, 595-600. Go to original source... Go to PubMed...
    16. DEFRA (2013): Schmallenberg virus. Avialable online at: http://www.defra.gov.uk/ahvla-en/disease-control/non-notifiable/schmallenberg/ Accessed 10May, 2013.
    17. Dong H, Li P, Elliott RM, Dong C (2013): Structure of Schmallenberg orthobunyavirus nucleoprotein suggests a novel mechanism of genome Encapsidation. Journal of Virology 87, 5593-5601. Go to original source... Go to PubMed...
    18. Elbers AR, Loeffen WL, Quak S, de Boer-Luijtze E, van der Spek AN, Bouwstra R, Maas R, Spierenburg MA, de Kluijver EP, van Schaik G, van der Poel WH (2012): Seroprevalence of Schmallenberg virus antibodies among dairy cattle, the Netherlands, winter 2011- 2012. Emerging Infectious Diseases 18, 1065-1071. Go to original source... Go to PubMed...
    19. Elliott RM, Blakqori G (2011): Molecular biology of orthobunyaviruses. In: Phyusnin A, Elliott RM (eds): Bunyaviridae. Caister, Norfolk. 1-39.
    20. Elliott RM, Blakqori G, van Knippenberg IC, Koudriakova E, Li P, McLees A, Shi X, Szemiel AM (2013): Establishment of a reverse genetic system for Schmallenberg virus, a newly emerged orthobunyavirus in Europe. Journal of General Virology 94, 851-859. Go to original source... Go to PubMed...
    21. European Food Safety Authority (2012): Schmallenberg virus: likely epidemiologival scenarios and data needs. Technical report. Supporting publications 2012: EN360. Parma, Italy.
    22. Evans CA, Reynolds JM, Reynolds ML, Saunders NR, Segal MB (1974): The development of a blood-brain barrier mechanism in foetal sheep. Journal of Physiology 238, 371-386. Go to original source... Go to PubMed...
    23. Fischer M, Hoffmann B, Schirrmeier H, Wernike K, Wegelt A, Goller K, Hoper D, Beer M (2012): Development of a pan-Simbu real-time RT-PCR for the reliable detection of Simbu serogroup viruses (Abstract). In: The Proceedings of Epizone, 6th Annual Meeting Satellite Symposium on the topic 'Schmallenberg virus', 15th June 2012, Brighton, UK.
    24. FLI (2012): FLI (Friedrich-Loeffler-Institut) press release. Available online at: http://www.fli.bund.de/en/startseite/press-releases/presse-informationsseite/Pressemitteilung/schmallenberg-virus-erstmals-sichtbar-gemacht.html. Accesses 10 May, 2013.
    25. FLI (2013a): Schmallenberg virus: Current Information on Schmallenberg virus. Last updated May 7, 2013. Available online at: www.fli.bund.de/en/startseite/ current-news/animal-disease-situation/new-orthobunyavirus-detected-in-cattle-in-germany.html. Accessed on 16 May, 2013.
    26. FLI (2013b): Information of the Friedrich-Loeffler-Institut on Schmallenberg virus (SBV) (European Shamonda-like orthobunyavirus). Last updated 31 January 2013. Available online at: http://www.fli.bund.de/fileadmin/dam_uploads/tierseuchen/Schmallenberg_Virus/FLI_Factsheet_on_Schmallenberg-Virus_130131.pdf. Accessed on 12 May, 2013.
    27. Garigliany MM, Hoffmann B, Dive M, Sartelet A, Bayrou C, Cassart D, Beer M, Desmecht D (2012a): Schmallenberg virus in calf born at term with porencephaly, Belgium. Emerging Infectious Diseases 18, 1005-1006. Go to original source... Go to PubMed...
    28. Garigliany MM, Bayrou C, Kleijnen D, Cassart D, Jolly S, Linden A, Desmecht D (2012b): Schmallenberg virus: a new Shamonda/Sathuperi-like virus on the rise in Europe. Antiviral Research 95, 82-87. Go to original source... Go to PubMed...
    29. Gibbens N (2012): Schmallenberg virus: a novel viral disease in Europe. Veterinary Record 14, 58-58. Go to original source... Go to PubMed...
    30. Goller KV, Hoper D, Schirrmeier H, Mettenleiter TC, Beer M (2012): Schmallenberg virus as possible ancestor of Shamonda virus. Emerging Infectious Disease 18, 1644-1646. Go to original source... Go to PubMed...
    31. Hahn K, Habierski A, Herder V, Wohlsein P, Peters M, Hansmann F, Baumgärtner W (2013): Schmallenberg virus in central nervous system of ruminants. Emerging Infectious Disease 19, 54-55. Go to original source... Go to PubMed...
    32. Herder V, Wohlsein P, Peters M, Hansmann F, Baumgartner W (2012): Salient lesions in domestic ruminants infected with the emerging so-called Schmallenberg virus in Germany. Veterinary Pathology 49, 588-591. Go to original source... Go to PubMed...
    33. Hoffmann, B. Scheuch M, Hoper D, Jungblut R, Holsteg M, Schirrmeier H, Eschbaumer M, Goller KV, Wernike K, Fischer M, Breithaupt A, Mettenleiter TC, Beer M (2012): Novel Orthobunyavirus in Cattle, Europe, 2011. Emerging Infectious Diseases 18, 469-472. Go to original source... Go to PubMed...
    34. IDEXX (2013): IDEXX Schmallenberg Ab Test. Available online at: http://www.idexx.com/pubwebresources/pdf/en_us/livestock-poultry/schmallenberg-ab-testus-ss.pdf. Accessed 16 May, 2013.
    35. Larska M, Polak MP, Grochowska M, Lechowski L, Zwiazek JS, Zmudzinski JF (2013): First report of Schmallenberg virus infection in cattle and midges in Poland. Transboundary Emerging Diseases 60, 97-101. Go to original source... Go to PubMed...
    36. Loeffen W, Quak S, de Boer-Luijtze E, Hulst M, van der Poel W, Bouwstra R, Maas R (2012): Development of a virus neutralisation test to detect antibodies against Schmallenberg virus and serological results in suspect and infected herds. Acta Veterinaria Scandinavica 54, 44. Go to original source... Go to PubMed...
    37. Marsh (2008): The economic and social impact of emerging infectious disease: mitigation through detection, research, and response. Marsh Inc. Compliance # MA8-10342. Avilable online at: http://www.healthcare.philips.com/main/shared/assets/documents/bioshield/ecoandsocialimpactofemerginginfectiousdisease_111208.pdf.
    38. Meroc E, Poskin A, Van Loo H, Quinet C, Van Driessche E, Delooz L, Behaeghel I, Riocreux F, Hooyberghs J, De Regge N, Caij AB, van den Berg T, van der Stede Y (2013a). Large-scale cross-sectional serological survey of Schmallenberg virus in Belgian cattle at the end of the first vector season. Transboundary Emerging Diseases 60, 4-8. Go to original source... Go to PubMed...
    39. Meroc E, De Regge N, Riocreux F, Caij AB, van den Berg T, van der Stede Y (2013b): Distribution of Schmallenberg virus and seroprevalence in Belgian sheep and goats. Transboundary Emerging Diseases. doi: 10.1111/tbed.12050. [Epub ahead of print]. Go to original source... Go to PubMed...
    40. OIE (2013): Schmallenberg virus: OIE Technical Fact Sheet. February, 2013. Available online at: http://www.oie.int/fileadmin/Home/eng/Our_scientific_expertise/docs/pdf/A_Schmallenberg_virus.pdf. Accessed 12 May, 2013.
    41. Peperkamp K, Dijkman R, van Maanen C, Vos J, Wouda W, Holzhauer M, van Wuijckhuise L, Junker K, Greijdanus S, Roumen M (2012): Polioencephalo-myelitis in a calf due to infection with Schmallenberg virus. Veterinary Record 170, 570. Go to original source... Go to PubMed...
    42. Plyusnin A, Beaty BJ, Elliott RM, Goldbach R, Kormelink R, Lundkvist A, Schmaljohn CS, Tesh RB (2012): Bunyaviridae. In: King AMQ, Adams MJ, Carstens EB, Lefkowits EJ (eds.): Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. Elsevier Academic Press, London. 725-741. Go to original source...
    43. Rasmussen LD, Kristensen B, Kirkeby C, Rasmussen TB, Belsham GJ, Bodker R, Botner A (2012): Culicoids as vectors of Schmallenberg virus. Emerging Infectious Diseases 18, 1204-1206. Go to original source... Go to PubMed...
    44. Saeed MF, Li L, Wang H, Weaver SC, Barrett AD (2001): Phylogeny of the Simbu serogroup of the genus Bunyavirus. Journal of General Virology 82, 2173-2181. Go to original source... Go to PubMed...
    45. Sailleau C, Breard E, Viarouge C, Desprat A, Doceul V, Lara E, Languille J, Vitour D, Attoui H, Zientara S (2013): Acute Schmallenberg virus infections, France, 2012. Emerging Infectious Diseases 19, 321-322. Go to original source... Go to PubMed...
    46. USDA-APHIS (2012): Schmallenberg virus case definition & guidance. United States Department of Agriculture - Animal and Plant Health Inspection Service - veterinary services. Available online at: http://www.nd.gov/ndda/files/resource/SchmallenbergCaseDefinitionandGuidance.pdf. Accessed 16 May, 2013.
    47. van den Bergh T (2012): Schmallenberg virus - Europe (26): vector, morphology. ProMED-mail post avialble at http://www.promedmail.org/direct.php?id=20120311.1066949. Accessed 10 May, 2013.
    48. Varela M, Schnettler E, Caporale M, Murgia C, Barry G, McFarlane M, McGregor E, Piras IM, Shaw A, Lamm C, Janowicz A, Beer M, Glass M, Herder V, Hahn K, Baumgartner W, Kohl A, Palmarini M (2013): Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host. PLoS Pathogens 9, e1003133. doi:10.1371/journal.ppat.1003133. Go to original source... Go to PubMed...
    49. Veronesi E, Henstock M, Gubbins S, Batten C, Manley R, Hoffmann B, Beer M, Attoui H, Clement Mertens PP, Barber J, Carpenter S (2013): Implicating culicoides biting midges as vectors of Schmallenberg virus using semi-quantitative RT-PCR. PLoS ONE 8, 1-8. Go to original source...
    50. Wernike K, Eschbaumer M, Schirrmeier H, Blohm U, Breithaupt A, Hoffmann B, Beer M (2013): Oral exposure, reinfection and cellular immunity to Schmallenberg virus in cattle. Veterinary Microbiology. 2013 Feb 7. pii: S0378-1135(13)00092-8. doi: 10.1016/j.vetmic.2013.01.040. [Epub ahead of print]. Go to original source... Go to PubMed...
    51. Yanase T, Kato T, Aizawa M, Shuto Y, Shirafuji H, Yamakawa M, Tsuda T (2012): Genetic reassortment between Sathuperi and Shamonda viruses of the genus Orthobunyavirus in nature: implications for their genetic relationship to Schmallenberg virus. Archives of Virology 157, 1611-1616. Go to original source... Go to PubMed...

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