Molecular diversity in pathogenic variants of Vibrio parahaemolyticus in Peru

Authors

DOI:

https://doi.org/10.17843/rpmesp.2020.372.4984

Keywords:

Vibrio parahaemolyticus, Public Health, Epidemiological Monitoring, Molecular Typing, Whole Genome Sequencing

Abstract

During the period from 1995 to 2017, in order to determine the diversity of Vibrio parahaemolyticus pathogenic variants in Peru, 102 Peruvian genomes (97 from a hospital setting and 5 from an out-of-hospital setting) were analyzed using the multilocus typification scheme and BLASTn in the search for virulence genes. Fifteen different sequence types were identified. It was found that the ST3 genotype, which is found in the pandemic clone, was the most abundant, with 52% (n=53); followed by ST120, with 23.5% (n=24); and the CC345 clonal complex, with 11.8% (n=12). A total of 89 analyzed strains presented genes encoding the pathogenicity island VpaI-7 (87.3%), while 96 presented the tdh gene (94.1%), and 6 the trh gene (5.9%). The ST3 genotype was the predominant one during the evaluated period, this genotype was the cause of a major outbreak in Peru’s past history. Other pathogenic genotypes found represent a latent public health risk associated with seafood consumption.

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Author Biographies

  • Junior Caro-Castro, Instituto Nacional de Salud, Lima, Perú. Universidad Nacional Mayor de San Marcos, Lima, Perú. Biólogo, bachiller en Microbiología y Parasitología
    Laboratorio de Referencia Nacional de Enteropatógenos - Tesista y colaborador de proyectos
  • Orson Mestanza, Instituto Nacional de Salud, Lima, Perú. biólogo, magíster en Bioinformática
    Laboratorio de Referencia Nacional de Enteropatógenos - Colaborador de proyectos
  • Willi Quino, Instituto Nacional de Salud, Lima, Perú. tecnólogo médico, magíster en Microbiología
    Laboratorio de Referencia Nacional de Enteropatógenos - Investigador
  • Ronnie G. Gavilán, Instituto Nacional de Salud, Lima, Perú. Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Lima, Perú. biólogo, doctor en Bioquímica y Biología Molecular
    Laboratorio de Referencia Nacional de Enteropatógenos - Investigador

Published

2020-06-01

Issue

Section

Brief Report

How to Cite

1.
Caro-Castro J, Mestanza O, Quino W, Gavilán RG. Molecular diversity in pathogenic variants of Vibrio parahaemolyticus in Peru. Rev Peru Med Exp Salud Publica [Internet]. 2020 Jun. 1 [cited 2024 Mar. 29];37(2):270-5. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/4984

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