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Abstract

Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.

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An addendum has been published for this content:
Addendum for Euro Surveill. 2021;26(1)
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/content/10.2807/1560-7917.ES.2020.26.1.2002106
2021-01-07
2024-04-20
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.26.1.2002106
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References

  1. Leung K, Lipsitch M, Yuen KY, Wu JT. Monitoring the fitness of antiviral-resistant influenza strains during an epidemic: a mathematical modelling study. Lancet Infect Dis. 2017;17(3):339-47.  https://doi.org/10.1016/S1473-3099(16)30465-0  PMID: 27914853 
  2. Leung K, Pei Y, Leung GM, Lam TT, Wu JT. Empirical transmission advantage of the D614G mutant strain of SARS-CoV-2; medRxiv 2020.  https://doi.org/10.1101/2020.09.22.20199810 
  3. Rambaut A, Loman N, Pybus O, Barclay W, Barrett J, Carabelli A, et al. Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. Virological; 2020. Available from: https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563
  4. Public Health England (PHE). Investigation of novel SARS-COV-2 variant: Variant of Concern 202012/01: Technical briefing document on novel SARS-CoV-2 variant. London: PHE; 21 Dec 2020. Available from: https://www.gov.uk/government/publications/investigation-of-novel-sars-cov-2-variant-variant-of-concern-20201201
  5. COVID-19 Genomics UK (COG-UK) Consortium. COG-UK 2020-12-20: SARS-CoV-2 in the UK. London: Microreact. [Accessed: 19 Dec 2020]. Available from: https://beta.microreact.org/project/7AJj5nS4JMCNYuxL9WCaz4-cog-uk-2020-12-20-sars-cov-2-in-the-uk/
  6. Bloom JD. SARS-CoV-2 RBD DMS. 2020. Available from: https://jbloomlab.github.io/SARS-CoV-2-RBD_DMS/
  7. Starr TN, Greaney AJ, Hilton SK, Ellis D, Crawford KHD, Dingens AS, et al. Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding. Cell. 2020;182(5):1295-1310.e20.  https://doi.org/10.1016/j.cell.2020.08.012  PMID: 32841599 
  8. Teruel N, Mailhot O, Najmanovich RJ. Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants. bioRxiv. 2020.  https://doi.org/10.1101/2020.12.16.423118 
  9. COVID-19 Genomics UK (COG-UK) Consortium. Update on new SARS-CoV-2 variant and how COG-UK tracks emerging mutations. Hinxton: Wellcome Sanger Institute; 14 Dec 2020. Available from: https://www.cogconsortium.uk/news_item/update-on-new-sars-cov-2-variant-and-how-cog-uk-tracks-emerging-mutations/
  10. Price MN, Dehal PS, Arkin AP. FastTree 2--approximately maximum-likelihood trees for large alignments. PLoS One. 2010;5(3):e9490.  https://doi.org/10.1371/journal.pone.0009490  PMID: 20224823 
  11. Leung K, Wu JT, Liu D, Leung GM. First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment. Lancet. 2020;395(10233):1382-93.  https://doi.org/10.1016/S0140-6736(20)30746-7  PMID: 32277878 
  12. Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020;20(5):533-4.  https://doi.org/10.1016/S1473-3099(20)30120-1  PMID: 32087114 
  13. BBC News. Covid-19: 'Our duty' to act over Christmas plans, says Matt Hancock. London: BBC News; 20 Dec 2020. Available from: https://www.bbc.com/news/uk-55382861
  14. Rambaut A, Holmes EC, O’Toole Á, Hill V, McCrone JT, Ruis C, et al. A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology. Nat Microbiol. 2020;5:1403-7.
  15. Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, et al. Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa; medRxiv 2020.  https://doi.org/10.1101/2020.12.21.20248640 
  16. Patel AB, Verma A. Nasal ACE2 levels and COVID-19 in children. JAMA. 2020;323(23):2386-7.  https://doi.org/10.1001/jama.2020.8946  PMID: 32432681 
  17. Kemp S, Datir R, Collier D, Ferreira I, Carabelli A, Harvey W, et al. Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ΔH69/ΔV70. bioRxiv. 2020.
  18. Kemp SA, Collier DA, Datir R, Gayed S, Jahun A, Hosmillo M, et al. Neutralising antibodies drive Spike mediated SARS-CoV-2 evasion; medRxiv 2020.
  19. Volz E, Hill V, McCrone JT, Price A, Jorgensen D, O’Toole Á, et al. Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity. Cell. 2020;S0092-8674(20)31537-3.  PMID: 33275900 
  20. Public Health England (PHE). Investigation of novel SARS-CoV-2 variant. Variant of Concern 202012/01. Technical briefing 2. London: PHE; 2020. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/948152/Technical_Briefing_VOC202012-2_Briefing_2_FINAL.pdf
Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Kathy+Leung&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leung Kathy</a>, <a href="/search?value1=Marcus+HH+Shum&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shum Marcus HH</a>, <a href="/search?value1=Gabriel+M+Leung&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leung Gabriel M</a>, <a href="/search?value1=Tommy+TY+Lam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lam Tommy TY</a>, <a href="/search?value1=Joseph+T+Wu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wu Joseph T</a></span>. Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(1):pii=2002106. <a href="https://doi.org/10.2807/1560-7917.ES.2020.26.1.2002106" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.26.1.2002106</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 20 Dec 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 28 Dec 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.26.1.2002106
/content/10.2807/1560-7917.ES.2020.26.1.2002106
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