Rev Esp Quimioter 2022;35(Suppl.1):28-30

Ceftaroline in severe community-acquired pneumonia

CATIA CILLONIZ, JUAN M PERICÀS, JORGE ROJAS

Published: 22 April 2022

http://www.doi.org/10.37201/req/s01.06.2022

Severe community-acquired pneumonia (SCAP) is associated with high mortality. Factor such as early adequate antibiotic therapy, delay in intensive care unit (ICU) care and pneumonia caused by resistant pathogens are associated with worse outcomes in SCAP patients. Ceftaroline is a fifth-generation cephalosporin with bactericidal activity against Gram-positive pathogens (including methicillin-resistant Staphylococcus aureus [MRSA] and multidrug-resistant Streptococcus pneumoniae) and common Gram-negative organisms. The efficacy and safety for the treatment of pneumonia was evaluated in three randomized control trials were ceftaroline demonstrated superiority against ceftriaxone for the treatment of pneumonia in hospitalized patients with Pneumonia Severity Index (PSI) III – IV.

Rev Esp Quimioter 2022; 35(Suppl. 1):28-30 [Full-text PDF]