Factores asociados a mortalidad en pacientes con Covid-19 en un hospital público
Resumen
El objetivo del estudio fue determinar los factores asociados a mortalidad hospitalaria enpacientes con enfermedad por coronavirus 2019 (COVID-19). Se realizóunestudioobservacional,analítico, de casos y controles.SeincluyeronpacienteshospitalizadoscondiagnósticodelaCOVID-19porpruebaserológicay/opruebamolecular entre el marzo y agosto del 2020. Para el análisis estadístico se empleó la prueba de Mann Whitney y para el análisis de los factores asociados se utilizó regresión logística. La significancia de p-valor fue <0,05.Seincluyó814pacientes,556(68,3%)fueron varonesy246(30,2%)mayoresde60años.La presencia de alguna comorbilidad se evidenció en 29,6%(241 pacientes); 35,8% (292)fallecieron.Lamedianadelaedaddelosfallecidosfuemayorencomparaciónalossobrevivientes(59vs49;p>0,01).Lascomorbilidades asociadas a la COVID-19 fueron: la obesidad (OR= 2,14; IC95%: 1,38 – 3,32)y la hipertensión arterial (OR=1,86; IC 95%: 1,06-3,24).Asimismo, niveles de saturación de oxígeno menor al 85% al ingreso al hospital(OR= 3,58; IC 95%: 2,82- 4,53); la edad mayor a 60 años (OR=1,96; IC 95%:1,54- 2,50) y el sexo masculino (OR= 1,64; IC95;1,12-2,39) fueron asociados amayormortalidad.Finalmente, losfactoresasociadosamortalidadhospitalaria fueron saturación de oxígeno menor al 85% alingreso al hospital, mayor de 60 años de edad, obesidad e hipertensiónarterial.
Palabras clave
Texto completo:
PDFReferencias
Albitar O, Ballauze R, Ori JP, Ghadzi SM. Risk factors for mortality among COVID-19 patients. Diabetes Res Clin Pract. 2020 Aug;166:108293 doi: 1016/j.diabres.2020.108293
Alizadehsani R, Alizadeh Sani Z, Behjati M, Roshanzamir Z, Hussain S, Abedini N, et al. Risk factors prediction, clinical outcomes, and mortality in COVID-19 patients. J Med Virol. 2021 Apr;93(4):2307-2320. doi: 10.1002/jmv.26699.
Bulut C, Kato Y. Epidemiology of COVID-19. Turk J Med Sci. 2020;50(3): 563-570 doi: 10.3906/sag-2004-172
Cao Z, Li T, Liang L, Wang H, Wei F, Meng S et al. Clinical characteristics of Coronavirus Disease 2019 patients in Beijing, China. PLOS ONE. 2020; 15(6): e0234764. https://doi.org/10.1371/journal.pone.0234764
Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020 Mar 26;368:m1091. doi: 10.1136/bmj.m1091. Erratum in: BMJ. 2020 Mar 31;368:m1295.
Cook TM. The importance of hypertension as a risk factor for severe illness and mortality in COVID-19. Anaesthesia. 2020 Jul; 75(7): 976-977 doi: 10.1111/anae.15103
Docherty A.B., Harrison E.M., Green C.A., Hardwick H., Pius R., Norman L. Features of 20133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020;369:m1985. doi: 10.1136/bmj.m1985
Harrison SL, Fazio-Eynullayev E, Lane D, Undershill P, Lip BYH. Comorbidities associated with mortality in 31 461 adults with COVID-19 in the United States: A federated electronic medical record analysis. PLoS Med. 2020; 17(9):e1003321 doi:10.1371/journal.gmed.1003321
Imam Z, Odish F, Gill I, O’Connor D, Armstrong J, Vanood A, et al. Older age and comorbidity are independent mortality predictors in a large cohort of J Intern Med. 2020. 288; 469-479 doi: 10.1111/joim.13119
Mikami T, Miyashita H, Yamada T, Harrington M, Steinberg D, Dunn A et al. Risk factors for mortality in patients with COVID-19 in New York City. J Gen Intern Med. 2020 Jun 30:1-10 doi: 10.1007/s11606-020-05983-Z
Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the the risk of patients with COVID-19 evidence from meta-analysis. Aging (Albany) NY. 2020 Apr 15; 12(7): 6049-6057 doi:10.18632/aging.103000
Maciel EL, Jabor P, Goncalves Junior E, Tristao-Sa R, Lima RCD, Reis- Santos B et al. factors associated with COVID-19 hospital deaths in Espirito, Santo, Brazil.2020. Epidemiol Serv Saude. 2020 Sep 25;29(4):e2020413 doi:10.1590/51679
Mehraeen E, Karimi A, Barzegary A, Vahedi F, Afsahi AM, Dadras O et al. Predictors of mortality in patients with COVID-19 a systematic review. Eu J Integr Med. 2020 Dec;40:101226 doi: 10.1016/j.eujim.2020.101226
Nachtigall I, Lenga P, Jozwiak K, Thurmann P, Meier-Hellmann A, Khulen R, et al. Clinical course and factors associated with outcomes among 1904 hospitalized COVID-19 patients in Germany: an observational study. Microbiol Infect. 2020;26(12):1663-1669 doi: 10.1016/j.cmi.2020.08.011
Noor FM, Islam MM. Prevalence and associated risk factors of mortality among COVID-19 patients: A meta-analysis. J Community Health. 2020;45: 1270-1282 Http://doi.org/10.1007/s10900-020-00920-x
Núñez-Gil IJ, Fernández-Pérez C, Estrada V, Becerra-Muñoz VM, El- Battrawy I, Uribarri A, et al. Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry. Intern Emerg Med. 2020 Nov 9:1–10. doi: 10.1007/s11739-020-02543-5.
Pan F, Yang L, Li Y, Liang B, Li L,Ye T et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case- control study. Int J Med Sci. 2020;17(9): 1281-1292 doi: 10.7150/ijms.46614
Posso M, Comas M, Roman M, Domingo L,Louro J, Gonzalez L et al. Comorbidities and mortality in patients with COVID-19 aged 60 years and older in a University Hospital in Spain. Arch Bronco Neumol. 2020 Nov;56(11):756- 758 doi: 10.1016/j.arbres.2020.06.012
Petrova D, Salamanca-Fernandez E, Rodriguez M, Navarro P, Jimenez JJ, Sanchez MJ. La obesidad como factor de riesgo en personas con COVID-19: posibles mecanismos e implicaciones. Aten Primaria. 2020 Aug-Sep;52(7):496- 500 doi: 10.1016/j.aprim.2020.05.003
Rosenthal N, Cao Z, Gundrum J et al. Risk factors associated with in hospital mortality in a US National sample of patients with COVID-19. JAMA Netw Open.2020;3(12):e2029058 doi:10.1001/jamanetworkopen.2020.29058
Salzberger B, Buder F, Lampl B, Ehrenstein B, Hitzenbichler F, Holzmann T, Schmidt B, Hanses F. Epidemiology of SARS-CoV-2. Infection. 2021 Apr;49(2):233-239. doi: 10.1007/s15010-020-01531-3.
Sanyoolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P et al.
Comorbidity and its Impact on patients with COVID-19. SN Compr Clin Med.2020 Jun 25;1-8 doi:10.1007/s42399.020.00363.4
Shibata S, Arima H, Asayama K, Hoshide S, Ichihara A, Ishimitsu et al. Hypertension and related diseases in the era of COVID-19: a report from the Japanese Society of Hypertension task Force on COVID 19. Hip res. 2020 jul 31:1-19 doi: 10.1038/s41440-20-0515-0
Silverio A, Di Maio M, Citro R, Esposito L, Iuliano G, Bellino M, et al. Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients. BMC Cardiovasc Disord. 2021 Jan 7;21(1):23. doi: 10.1186/s12872-020-01816-3.
Ssentongo P, Ssentongo AE, Heilbrunn ES, Ba DM, Chinchili VM. Association of cardiovascular disease and 10 other preexisting comorbidities with COVID-19 mortality: A systematic review and meta-analysis. PLoSOne. 2020;15(8): e0238215 https://doi.org/10.1371/journal.pone.0238215
Tian W, Jiang W, Yao J, Nicholson CJ, Li R, Sigurslid HH et al. Predictors of mortality in hospitalized COVID-19 patients: A systemic review and meta-analysis. J Med Virol.2020 May 22:10.1002/jmv.26050 doi:10.1002/jmv.26050
Van Halem K, Bruyndonckx R, Van der hilst J, Cox J, Driesen P, Opsomer M, et al. Risk factors for mortality in hospitalized patients with COVID-19 at the start of the pandemic in Belgium: a retrospective cohort study. BMC Infect Dis. 2020;20(1):897 doi: 10.1186/s12879-020-0505-3
Wang Y, Xu J, Hou H, Shi L, Yang H. Prevalence of comorbid tuberculosis amongst COVID-19 patients: A rapid review and meta-analysis. Int J Clin Pract. 2021 Nov;75(11):e14867. doi: 10.1111/ijcp.14867
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Centers for Disease Control and Prevention. JAMA apr 17. 2020;323: 1239-1242 doi: 10.1001/jama.2020.2648. PMID:
Xie J, Covassin N, Fan Z, Singh P, Gao W, Li G, et al. Association between hypoxemia and mortality in patients with COVID-19. Mayo Clin Proc. 2020 Jun;95(6): 1138-1147 doi: 10.1016/j.mayocp.2020.04.006
Zhou F, Yu T, Du R, Fan G, Liu Y. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–1062.
Zhu L, She ZG, Cheng X, Quin JJ, Zhang XJ, Cai J et al. Association of blood glucose control and outcomes in patients with COVID-19 and pre-existing type 2 diabetes. Cell Metal. 2020. Jun 2;31(6):1068-1077.e3. doi:10.1016/j.cmet.2020.04.021
Enlaces refback
- No hay ningún enlace refback.
Copyright (c) 2022 Boletín de Malariología y Salud Ambiental