Regular ArticleImmunomodulation of Murine Cytomegalovirus-Induced Myocarditis in Mice Treated with Lipopolysaccharide and Tumor Necrosis Factor☆
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Cellular Immunity: A Role for Cytokines
2017, Handbook of Systemic Autoimmune DiseasesCitation Excerpt :For example, administration of IL-1 or IL-2 augments disease in CVB3-infected susceptible mice (Table 1.3) (Huber et al., 1994), while blocking these receptors inhibits the development of myocarditis (Neumann et al., 1993). On the other hand, C57BL/6 mice, which are resistant to the development of chronic myocarditis following CVB3 or MCMV infection, can be induced to develop chronic myocarditis by administration of LPS (a generator of several proinflammatory cytokines), IL-1β, or TNF-α with the virus (Table 1.3) (Lane et al., 1991, 1992; Lenzo et al., 2001). Cytokines may play a number of different roles.
Understanding Interferon Subtype Therapy for Viral Infections: Harnessing the Power of the Innate Immune System.
2016, Cytokine and Growth Factor ReviewsCitation Excerpt :Post-viral myocarditis develops following exposure to CMV and can lead to chronic disease with end stage dilated cardiomyopathy and congestive heart failure [44]. The disease is associated with autoantibody production to heart antigens (e.g. cardiac myosin) and can be exacerbated in otherwise resistant mouse strains with administration of lipopolysaccharide and tumour necrosis factor with MCMV infection [45]. Cardiac inflammation ranges from focal to diffuse cell infiltration of the myocardium and pericardium with degenerative changes in myofibres and irreversible fibrosis.
In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis
2010, Cardiovascular PathologyCitation Excerpt :In the sensitive mouse strain, BALB/c, infectious virus is not detected after Day 10 post-infection (p.i.); furthermore, active viral replication is not required for the development of chronic myocarditis [4,6]. As with human disease, the pathogenesis of MCMV-induced myocarditis appears to be primarily due to the immunological response of the murine host to the virus [4,6,7]. Cytokines are known to play a role in the host immune response to MCMV in the heart [6,8,9].
Murine Cytomegalovirus and Other Herpesviruses
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This work was supported by the Australian National Health and Medical Research Council (Project Grants 961312 and 000264).
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Current address: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
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To whom correspondence and reprint requests should be addressed Dr Cassandra M Lawson, Division of Veterinary and Biomedical Sciences, Murdoch University, Perth 6150, Australia. Fax: 618 9310 4144. E-mail: [email protected].