Regular ArticleROLE OF TYPE I INTERFERONS DURING MACROPHAGE ACTIVATION BY LIPOPOLYSACCHARIDE
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2018, Developmental and Comparative ImmunologyRole of cellular metabolism in regulating type I interferon responses: Implications for tumour immunology and treatment
2017, Cancer LettersCitation Excerpt :The selective use of NOS or arginase contributes to the functional polarization of these cells into inflammatory M1 or anti-inflammatory M2 phenotypes, respectively [180–182]. Type I IFN responses, increased expression of inducible NOS is associated with elevated levels of l-citrulline, NO and reactive nitrogen species (Fig. 1) [183,184]. This reprogramming plays and accumulation of these bioactive metabolites plays an important role in mediating cytostatic or cytotoxic activities against viruses, bacteria, fungi, protozoa, helminths and tumour cells [176].
Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages
2015, Clinical Immunology
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Correspondence to: Dr Peter Vadiveloo, Bernard O'Brien Institute of Microsurgery, St. Vincent's Hospital Melbourne, Fitzroy, Australia, 3065. E-mail:[email protected]
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