Regular ArticleMotility and Ramification of Human Fetal Microglia in Culture: An Investigation Using Time-Lapse Video Microscopy and Image Analysis
References (72)
- et al.
Evidence for motility and pinocytosis in ramified microglia in tissue culture
Brain Res.
(1991) - et al.
Fibronectin and laminin regulate the in vitro differentiation of microglia cells
Neuroscience
(1991) - et al.
The origin and differentiation of microglial cells during development
Prog. Neurobiol.
(1998) - et al.
Extracellular acidification decreases the basal motility of cultured mouse microglia via the rearrangement of the actin cytoskeleton
Brain Res.
(2000) Colony-stimulating factors regulate programmed cell death of rat microglia/brain macrophages in vitro
J. Neuroimmunol.
(1995)- et al.
Further studies on the identification of microglia in mixed brain cell cultures
Brain Res. Bull.
(1989) - et al.
SCI/MIP-1 alpha: A potent stem cell inhibitor with potential roles in development
Dev. Biol.
(1992) - et al.
Isolation and characterisation of human fetal brain-derived microglia in vitro culture
Neuroscience
(1991) - et al.
Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells
J. Neuroimmunol.
(1995) - et al.
Identification of microglia in primary cultures of mixed cerebral cortical cells
Brain Res. Bull.
(1987)
Human microglial cultures: A powerful model to study their origin and immunoreactive capacity
Int. J. Dev. Neurosci.
Production of granulocyte/macrophage colony stimulating factor by cultured astrocytes
Biochem. Biophys. Res. Commun.
Differences between the clearance of apoptotic cells by professional and non-professional phagocytes
Curr. Biol.
Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C
Brain Res.
Neurons induce the activation of microglial cells in vitro
Exp. Neurol.
Morphological transformation of microglia in vitro
Brain Res.
Effects of colony-stimulating factors on isolated microglia in vitro
J. Neuroimmunol.
Microglial ramification requires nondiffusible factors derived from astrocytes
Exp. Neurol.
Morphological differentiation of microglial cells in culture: Involvement of insoluble factors derived from astrocytes
Neurosci. Res.
Characterisation of the dynamic nature of microglial cells
Brain Res. Bull.
Apoptosis of cultured microglia by the deprivation of macrophage colony-stimulating factor
Neurosci. Res.
White matter microglia produce membrane-type matrix metalloproteases, an activator of gelatinase A, in human brain tissues
Acta Neuropathol.
Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain
Proc. Natl. Acad. Sci. USA
Microglia in colony-stimulating factor 1-deficient op/op mice
J. Neurosci. Res.
Membrane properties of ameboid microglial cells in the corpus callosum slice from early postnatal mice
J. Neurosci.
Phagocytosing ameboid microglial cells studied in a mouse corpus callosum slice preparation
Glia
Production of monocyte chemotactic protein-1 by rat brain macrophages
Eur. J. Neurosci.
Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro
J. Neurosci. Res.
Function of microglia in organotypic slice cultures
J. Neurosci. Res.
Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: A morphometrical study
Glia
Growth control of cultured microglia
J. Neurosci. Res.
Colony-stimulating factors as promoters of ameboid microglia
J. Neurosci.
Exposure of cultured microglial cells to interferon-gamma
Altern. Lab. Anim.
Fluorescent dye prelabelled microglial cells migrate into organotypic hippocampal slice cultures and ramify
Eur. J. Neurosci.
Production of colony stimulating factor-1 (CSF-1) by mouse astroglia in vitro
J. Neurosci. Res.
Cited by (59)
Recent advances in the understanding of microglial development and homeostasis
2018, Cellular ImmunologyMicroglia in CNS development: Shaping the brain for the future
2017, Progress in NeurobiologyCitation Excerpt :In particular, the expression of MMP-8 and −9 plays a key role in the spreading of microglia and MMP inhibition impairs microglia expansion (Kierdorf et al., 2013). Similarly to the migration of oligodendrocytic cells, the migration of the microglial cells could be guided by a gradient of guiding cues such as semaphorins and netrins (Spassky et al., 2002) but also by chemoattracting molecules such as MCP1, MIP-1alpha (Rezaie et al., 2002), CXCL12 (Arno et al., 2014) or ligands of CSF-1R and VGEFR1 (Lelli et al., 2013). In the postnatal CNS, other neuronal factors help microglial cells to reach their final destination in the CNS parenchyma.
Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory
2017, Neurobiology of Learning and MemoryRegulation of brain microglia by female gonadal steroids
2015, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :Microglial cells after having invaded the brain typically acquire a ramified morphology [42]. This ramification process which is often termed as developmental plasticity occurs simultaneously with the radial migration of microglia [43] and has been confirmed in vitro [44]. This branching habit containing a small soma and several thin and branched processes provides a large surface area and allows covering a broader area in the surrounding to sense and monitor changes in their local environment.
Understanding the behavioural phenotype of the precocial spiny mouse
2014, Behavioural Brain ResearchCitation Excerpt :However, spiny mice appear to display inherently lower levels of anxiety and fear compared to conventional rodents, as our wild-type adult spiny mice demonstrate comparable patterns of open field, central zone activity as do adult rats selectively bred from a low-anxiety behaviour line [34]. Spiny mice also show greater activity in open (dangerous/fearful) arms of the EPM compared to adult mice [35]. The novel object recognition test involves making alterations to previously stored information, and is thus an assessment of memory and learning [13,14,36].
- 1
To whom reprint requests should be addressed. Fax: +44-207-708-3895. E-mail: [email protected].