Regular ArticleIdentification of a Second Murine Interleukin-11 Receptor α-Chain Gene (IL11Ra2) with a Restricted Pattern of Expression☆
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Cited by (28)
A panoramic review and in silico analysis of IL-11 structure and function
2016, Cytokine and Growth Factor ReviewsCitation Excerpt :IL-11Rα1, the transmembrane isoform with a short cytoplasmic domain, is found in the brain, bone marrow, muscle, heart, lung, kidney, bladder, spleen, thymus, gastrointestinal tract, salivary glands, testis, ovaries, uterus, macrophages, T-cells, osteoblasts, and osteoclasts [59,60]. IL-11Rα2, the isoform without the cytoplasmic domain, is expressed only in lymph nodes, thymus, and testis [61]. Regulating factors of IL-11Rα expression have not been completely identified [28].
The role of IL-11 in immunity and cancer
2016, Cancer LettersCitation Excerpt :The growing body of clinical evidence suggesting the involvement of IL-11 in cancers particularly of epithelial origin makes the manipulation of IL-11 signaling a potential therapeutic target. Furthermore, the restricted, low-level expression pattern of IL-11 in normal tissues [26–28] may offer additional advantages to agents targeting IL-11 signaling in maintaining the overall integrity of the subject's health status during such treatment. However, only a few studies have been published to date on targeting IL-11 signaling in pre-clinical models of cancer [96,118,119].
Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
2007, BloodCitation Excerpt :As shown in Figure 7A, IL-11 and IL-11Rα gene expression was unchanged in gp130Y757F/Y757F thymocytes. Although it has previously been reported that a second IL-11Rα locus (IL-11Rα2) with restricted expression in the testes, thymus, and lymph nodes exists in some strains of mice,8 Q-PCR analyses failed to detect expression of either IL-11Rα locus in thymus and, as expected liver, of gp130Y757F/Y757F:IL-11Rα−/− mice (Figure 7B). Furthermore, unlike gp130Y757F/Y757F mice, IL-11 treatment of gp130Y757F/Y757F:IL-11Rα1−/− mice failed to induce STAT3 tyrosine phosphorylation in lymphoid and nonlymphoid organs (Figure 7C), thus confirming that IL-11 does not elicit a signal in gp130Y757F/Y757F:IL-11Rα1−/− mice.
Characterization and expression analysis of the chicken interleukin-11 receptor alpha chain
2005, Developmental and Comparative ImmunologyInterleukin-11
2003, The Cytokine HandbookESkine, a novel β-chemokine, is differentially spliced to produce secretable and nuclear targeted isoforms
1999, Journal of Biological Chemistry
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Sequence data from this article have been deposited with the EMBL/Genbank Data Libraries under Accession Nos. U69491 and U69492.
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