MinireviewRegulation of Transforming Growth Factor-β Signaling
References (109)
- et al.
J. Biol. Chem.
(1988) - et al.
Cytokine Growth Factor Rev.
(1999) - et al.
J Biol. Chem.
(1992) - et al.
Blood
(2000) - et al.
Cell
(1998) - et al.
Cell
(1999) - et al.
Am. J. Pathol.
(2000) - et al.
J. Biol. Chem.
(1987) - et al.
J. Biol. Chem.
(1995) - et al.
J. Biol. Chem.
(1995)
Exp. Neurol.
J. Biol. Chem.
J. Biol. Chem.
Am. J. Pathol.
Cell
Cell
Cell
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
Cell
Chem. Biol.
Cell
Cell
J. Biol. Chem.
Trends Cell Biol.
J. Biol. Chem.
J. Biol. Chem.
J Biol. Chem.
J. Biol. Chem.
Cell
Cell
J. Biol. Chem.
Mol. Cell
Cell
J. Biol. Chem.
Curr. Biol.
Cell
Mol. Cell
Mol. Cell
Cell
J. Biol. Chem.
J. Biol. Chem.
J. Biol. Chem.
Annu. Rev. Biochem.
Cited by (97)
SPSB1, a novel negative regulator of the transforming growth factor-β signaling pathway targeting the type II receptor
2015, Journal of Biological ChemistryCitation Excerpt :TGF-β signaling is tightly regulated at multiple levels both in and outside the target cells (1): both Lap and Ltbp facilitate secretion of TGF-β while retaining it in its inactive form at the basal state (14, 15); secreted molecules, such as decorin, bind directly to TGF-β ligands and neutralize their biological activity (16, 17); the transmembrane protein BAMBI sequesters ligand from binding to TβRI (18); Dapper2 promotes TβRI degradation (19); Fkbp12 blocks TβRI phosphorylation (20); TmepaI sequesters R-Smads from TβRI kinase activation (21); the E3 ubiquitin ligase Smurf1 degrades R-Smads (22) and Smad7-associated TβRI (23); and Smad7 directly competes with Smad2/3 for binding to TβRI (24). The negative regulator Smad7 is itself negatively regulated by Arkadia through ubiquitination and degradation (1). In the nucleus, transcriptional suppressors negatively regulate the transcriptional activity of the Smad complexes (25).
Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract
2014, Experimental Eye ResearchSoft-focused extracorporeal shock waves increase the expression of tendon-specific markers and the release of anti-inflammatory cytokines in an adherent culture model of primary human tendon cells
2014, Ultrasound in Medicine and BiologyCitation Excerpt :In particular, it has been found that mechanical forces regulate the expression of SCX through activation of a TGFβ/Smad-mediated pathway, which acts to maintain the integrity of the ECM. Transforming growth factor β is known to be involved in other phases of tissue healing, such as cell proliferation, cell viability and stimulation of collagen production (Zhu and Burgess 2001). Growth factors are among the most important molecules involved in the healing process, but their specific actions are not well characterized.
- 1
To whom correspondence should be addressed. Fax: +61-3-93413104. E-mail: [email protected].