A Neurocognitive Account of Frontal Lobe Involvement in Orthographic Lexical Retrieval: An fMRI Study

doi:10.1006/nimg.2001.0778

NeuroImage

Volume 14, Issue 1, July 2001, Pages 162-169

https://doi.org/10.1006/nimg.2001.0778 Get rights and content

Abstract

The present study aimed to examine the relationship between activation induced by an orthographic lexical retrieval (OLR) task and performance across time on the standard clinical version of OLR, the Controlled Oral Word Association Test (COWAT). The number of significantly activated pixels in a frontal lobe region of interest (encompassing middle and inferior frontal gyri) were measured for the left and right cerebral hemispheres in 20 volunteers. A relationship between the pixel count and the total number of words retrieved during the COWAT was found for the left but not the right hemisphere. Further examination of the left-sided relationship showed that the number of pixels in the left middle frontal region of interest correlated significantly with the second, but not the first, 30-s COWAT epoch. By contrast, the first epoch, but not the second, correlated significantly with the pixel count within the left inferior frontal region of interest. These relationships suggest differential involvement of dorsolateral and ventrolateral prefrontal cortex in specific cognitive processes fundamental to the production of language. Interindividual variation in activation levels may reflect underlying differences in cognitive processing capacity. This study is the first attempt to examine the relationship between fMRI activation and standard verbal fluency performance.

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Regular ArticleA Neurocognitive Account of Frontal Lobe Involvement in Orthographic Lexical Retrieval: An fMRI Study

Abstract

Brain Cogn.

Brain Lang.

Neuropsychologia

Cortex

Magn. Reson. Imag.

Brain Lang.

Verbal Productive Fluency: The Attentional Demands of Lexico-Semantic Access

The interaction between mood and cognitive function studied with PET

Psychol. Med.

Verbal fluency: Normative data

J. Clin. Psychol.

Functional MRI during word generation, using conventional equipment: A potential tool for language localization in the clinical environment

Neurology

The neural basis of the central executive system of working memory

Nature

The stroke syndrome of striatocapsular infarction

Brain

Word fluency in patients with early dementia of the Alzheimer's type

Br. J. Clin. Psychol.

Detection of hippocampal pathology in intractable partial epilepsy: Increased sensitivity with quantitative magnetic resonance T2 relaxometry

Neurology

MRI Neuroanatomy: A New Angle on the Brain

Language lateralization and localization using functional MRI

NeuroImage

Language lateralization in healthy right-handers

Brain

If neuroimaging is the answer, what is the question?

Philos. Trans. R. Soc. London, Section B

Regular Article
A Neurocognitive Account of Frontal Lobe Involvement in Orthographic Lexical Retrieval: An fMRI Study