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Advances in Production of Medicinal Mushrooms Biomass in Solid State and Submerged Bioreactors

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Biochemical Engineering and Biotechnology of Medicinal Mushrooms

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 184))

Abstract

Production of mushroom fruit bodies using farming technology could hardly meet the increasing demand of the world market. During the last several decades, there have been various basic and applied studies on fungal physiology, metabolism, process engineering, and (pre)clinical studies. The fundamental aspects of solid-state cultivation of various kinds of medicinal mushroom mycelia in various types of bioreactors were established. Solid-state cultivation of medicinal mushrooms for their biomass and bioactive metabolites production appear very suitable for veterinary use. Development of comprehensive submerged technologies using stirred tank and airlift bioreactors is the most promising technology for fast and large-scale production of medicinal fungi biomass and their pharmaceutically active products for human need. The potentials initiate the development of new drugs and some of the most attractive over-the-counter human and veterinary remedies. This article is to overview the engineering achievements in solid state and submerged cultivations of medicinal mushrooms in bioreactors.

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Abbreviations

a w :

Water activity

M :

Molecular mass of water

Mm:

Medicinal mushrooms

P :

Water vapor pressure

PDA:

Potato dextrose agar

P 0 :

Water vapor pressure of pure water

P/P0:

Equal to water activity

R :

Gas constant (8.31 J/mol K)

Smb:

Submerged bioprocessing

SSB:

Solid-state bioprocessing

SSC:

Solid-state cultivation

T :

Absolute temperature

Ψ:

Water potential

HSTR:

Horizontal stirred tank bioreactor

SBG:

Spent brewery grains

STR:

Stirred tank reactor

ALR:

Air lift reactor

rpm:

Rotation per minute

vvm:

Aeration volume/volume/minute

RBC:

Repeated-batch cultivation

GA:

Ganoderic acid

k L a :

Volumetric oxygen transfer coefficient

DO:

Dissolved oxygen

EPS:

Extracellular polysaccharides

IPS:

Intracellular polysaccharides

TA:

Triterpene acids

CCRD:

Central composite rotatable design

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Acknowledgments

Special gratitude to Univ.dipl.ing. Branko Škrinjar, Head of FKKT Library, University of Ljubljana, for his great contribution to the Literature support of this article. JJZ would like to thank the financial support by National Key R&D Program of China (No. 2018YFA0901900) and the National Natural Science Foundation of China (No. 31770037).

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Authors and Affiliations

  1. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia

    Marin Berovic

  2. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and Laboratory of Molecular Biochemical Engineering and Advanced Fermentation Technology, Department of Bioengineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

    Jian-Jiang Zhong

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  1. Marin Berovic
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  2. Jian-Jiang Zhong
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Correspondence to Marin Berovic or Jian-Jiang Zhong .

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Editors and Affiliations

  1. Department of Chemical and Biochemical Engineering, University of Ljubljana, Ljubljana, Slovenia

    Marin Berovic

  2. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

    Jian-Jiang Zhong

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Berovic, M., Zhong, JJ. (2022). Advances in Production of Medicinal Mushrooms Biomass in Solid State and Submerged Bioreactors. In: Berovic, M., Zhong, JJ. (eds) Biochemical Engineering and Biotechnology of Medicinal Mushrooms. Advances in Biochemical Engineering/Biotechnology, vol 184. Springer, Cham. https://doi.org/10.1007/10_2022_208

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