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Industrial Applications of Poly(lactic acid) pp 79–108Cite as

Tailoring Bulk and Surface Composition of Polylactides for Application in Engineering of Skeletal Tissues

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 282))

Abstract

Synthetic biodegradable polylactides have been used extensively to fabricate scaffolds for engineering skeletal tissues such as bone and cartilage. This chapter summarizes the application of polylactides in tissue engineering and shows strategies for tailoring its bulk and surface composition for optimized degradation rates, mechanical properties, and bioactivities that cannot be achieved with pure polylactide polymers. Hence, block copolymers and the use of blending as a cost-effective strategy are described here. Furthermore, polymeric networks are shown that are advantageous in porogen-leaching manufacture of scaffolds, in preventing crystallization during degradation, and in allowing the incorporation of hydrophilic chains. In addition, mechanical reinforcement of the polymer is achieved when organic–inorganic composites of polylactides are formed. The last part of this chapter focusses on the modification of the surface to tailor the biocompatibility of polylactides only, without changing the bulk properties of the material. Surface modification by wet chemical processes and adsorption of biogenic multilayers of glycosaminoglycans is described that not only significantly improves biocompatibility but may also help to drive differentiation of stem cells into the desired lineage.

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Acknowledgments

This work was supported by Marie Curie Industry-Academia Partnerships and Pathways (FP7-PEOPLE-2012-IAPP, with grant agreement PIAP-GA-2012-324386) and IOF-Marie Curie fellowship program (Protdel 331655) as well as the German Research Society (DFG) through Grant GR 1290/10-1 and the Spanish Ministry of Economy and Competitiveness through the MAT2016-76039-C4-1-R Project (including Feder funds).

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Authors and Affiliations

  1. Centre for Biomaterials and Tissue Engineering (CBIT), Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain

    Gloria Gallego Ferrer

  2. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza, Spain

    Gloria Gallego Ferrer

  3. Biomedical Materials Group, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Heinrich-Damerow-Strasse 4, 06120, Halle (Saale), Germany

    Andrea Liedmann, Marcus S. Niepel & Thomas Groth

  4. Interdisciplinary Center of Materials Science, Martin Luther University Halle-Wittenberg, 06099, Halle (Saale), Germany

    Marcus S. Niepel & Thomas Groth

  5. Faculty of Dentistry, University of Toronto, Toronto, ON, Canada

    Zhen-Mei Liu

Authors
  1. Gloria Gallego Ferrer
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  2. Andrea Liedmann
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  3. Marcus S. Niepel
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  4. Zhen-Mei Liu
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  5. Thomas Groth
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Corresponding author

Correspondence to Thomas Groth .

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Editors and Affiliations

  1. National Research Council, Institute of Polymers, Composites and Biomaterials, Pozzuoli, Italy

    Maria Laura Di Lorenzo

  2. Interdisciplinary Center for Transfer-Oriented Research in Natural Sciences, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany

    René Androsch

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Ferrer, G.G., Liedmann, A., Niepel, M.S., Liu, ZM., Groth, T. (2017). Tailoring Bulk and Surface Composition of Polylactides for Application in Engineering of Skeletal Tissues. In: Di Lorenzo, M., Androsch, R. (eds) Industrial Applications of Poly(lactic acid). Advances in Polymer Science, vol 282. Springer, Cham. https://doi.org/10.1007/12_2017_26

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