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Layered Fibrous Scaffolds/Membranes in Wound Healing

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Electrospun Polymeric Nanofibers

Part of the book series: Advances in Polymer Science ((POLYMER,volume 291))

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Abstract

Skin is the largest organ of the human body acting as a barrier to protect the body from external effects and trauma. As a result of external physical damages or physiological disorders such as diabetes, skin tissue is disrupted, and cellular integrity is lost in the wounded site. Design and production of functional bioactive wound dressing matrices to protect the injured area, assist the wound healing process and guide the regeneration of healthy tissue are of utmost importance. Considering the complexity of the wound healing process and challenging requirements to fulfill the clinical need in terms of both healing and regeneration, multi-layered fibrous membranes/scaffolds offer an effective strategy for the design and development of multi-functional wound-healing matrices. Such matrices act to stimulate the wound-healing cascade by combining different materials with different physicochemical and structural properties in each layer and integration of various bioactive molecules and therapeutic agents.

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Authors and Affiliations

  1. Biotechnology Institute, Ankara University, Ankara, Turkey

    Ayşe Günyaktı

  2. Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey

    Tuğrul Tolga Demirtaş

  3. Chemical Engineering Department, Faculty of Engineering, Ankara University, Ankara, Turkey

    Ayşe Karakeçili

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  1. Ayşe Günyaktı
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  2. Tuğrul Tolga Demirtaş
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  3. Ayşe Karakeçili
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Correspondence to Ayşe Karakeçili .

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  1. Polymeric Biomaterials Lab, School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (University), Kochi, India

    R. Jayakumar

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Günyaktı, A., Demirtaş, T.T., Karakeçili, A. (2022). Layered Fibrous Scaffolds/Membranes in Wound Healing. In: Jayakumar, R. (eds) Electrospun Polymeric Nanofibers. Advances in Polymer Science, vol 291. Springer, Cham. https://doi.org/10.1007/12_2022_124

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