Skip to main content
SpringerLink
Log in

Molekulare Regulation der Bildung und Inaktivierung reaktiver Sauerstoffspezies

  • Chapter
Molekularmedizinische Grundlagen von para- und autokrinen Regulationsstörungen

Part of the book series: Molekulare Medizin ((MOLMED))

  • 1353 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

1.7.6 Literatur

  • Agren UM, Tammi RH, Tammi MI (1997) Reactive oxygen species contribute to epidermal hyaluronan catablolismus in human skin organ culture. Free Radic Biol Med 23: 996–1001

    Article  PubMed  CAS  Google Scholar 

  • Arnhold J (2004) Free radicals — friends or foes? Properties, functions and secretion of human myeloperoxidase. Biochemistry (Moscow) 69: 4–9

    Article  CAS  Google Scholar 

  • Arnold S, Kadenbach B (2003) Stress modifiziert den Energiemetabolismus und verursacht Krankheiten. Biospektrum 6: 704–707

    Google Scholar 

  • Ashok BT, Ali R (2003) Aging research in India. Exp Gerontol 38: 597–603

    Article  PubMed  Google Scholar 

  • Aust AE, Eveleigh JF (1999) Mechanisms of DNA oxidation. Soc Exp Biol Med 222: 246–252

    Article  CAS  Google Scholar 

  • Bakonyi T, Rada Z (2004) High altitude and free radicals. J Sports Sci Med 3: 64–69

    Google Scholar 

  • Baldus S, Heeschen C, Meinertz T et al. (2003) Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 108: 1440–1445

    Article  PubMed  CAS  Google Scholar 

  • Balogh GT, Illes J, Szekely Z, Forrai E, Gere A (2003) Effect of different metal ions on the oxidative damage and antioxidant capacity of hyaluronic acid. Arch Biochem Biophys 410: 76–82

    Article  PubMed  CAS  Google Scholar 

  • Banner W Jr, Woolf AD (2004) Antidotes for poisoning by metals and metalloids. Deferoxamine. In: Bates N (ed) International Programme on chemical safety evaluation (WHO/ILO/UNEP). World Health Organization, National Poisons Information Service, London

    Google Scholar 

  • Baynes JW, Dominiczak MH (2005) Medical biochemistry. Elsevier Mosby, Philadelphia

    Google Scholar 

  • Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite — the good, the bad, and the ugly. Am J Physiol 271(Cell Physiol 40): C1424–C1437

    PubMed  CAS  Google Scholar 

  • Berlett BS, Stadtman ER (1997) Protein oxidation, disease, and oxidative stress. J Biol Chem 272: 20313–20316

    Article  PubMed  CAS  Google Scholar 

  • Berry C, Hamilton CA, Brosnan J et al. (2000) Investigation into the sources of superoxide in human blood vessels. Angiotensin II increases superoxide production in human internal mammary arteries. Circulation 101: 2206–2212

    PubMed  CAS  Google Scholar 

  • Berry CE, Hare JM (2003) Xanthine oxidoreductase and cardiovascular disease: Molecular mechanisms and pathophysiological implications. J Physiol 555: 589–606

    Article  PubMed  CAS  Google Scholar 

  • Biondi R, Xia Y, Rossi R, Paolocci N, Ambrosio G, Zweier JL (2001) Detection of hydroxyl radicals by D-phenylalanine hydroxylation: A specific assay for hydroxyl radical generation in biological systems. Anal Biochem 290: 138–145

    Article  PubMed  CAS  Google Scholar 

  • Bligh HF, Bartoszek A, Robson CN, Hickson ID, Kasper CB, Beggs JD, Wolf CR (1990) Activation of mitomycin C by NADPH:cytochrome P-450 reductase. Cancer Res 50: 7789–7792

    PubMed  CAS  Google Scholar 

  • Blumberg JB (2002) An update: Vitamin E supplementation and heart disease. Nutr Clin Care 5: 50–55

    Article  PubMed  Google Scholar 

  • Boelsterli UA (2003) Mechanistic toxicology. Taylor & Francis, London New York, pp 93–147

    Google Scholar 

  • Boschi-Muller S, Olry A, Antoine M, Branlant G (2005) The enzymology and biochemistry of methionine sulfoxide reductases. Biochim Biophys Acta 1703: 231–238

    PubMed  CAS  Google Scholar 

  • Bredt DS, Snyder SH (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 87(2): 682–685

    Article  PubMed  CAS  Google Scholar 

  • Brian JE, Faraci FM, Moore SA (2001) COX-2-dependent delayed dilatation of cerebral arterioles in response to bradykinin Am J Physiol Heart Circ Physiol 280: H2023–H2029

    PubMed  CAS  Google Scholar 

  • Brigelius-Flohé R, Traber MG (1999) Vitamin E: Function and metabolism. FASEB J 13: 1145–1155

    PubMed  Google Scholar 

  • Brodie AE, Reed DJ (1987) Reversible oxidation of glyceraldehyde 3-phosphate dehydrogenase thiols in human lung carcinoma cells by hydrogen peroxide. Biochem Biophys Res Commun 148: 120–125

    Article  PubMed  CAS  Google Scholar 

  • Brookes P, Darley-Usmar VM (2002) Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase. Free Radic Biol Med 32(4): 370–374

    Article  PubMed  CAS  Google Scholar 

  • Brown DR, Schulz-Schaeffer WJ, Schmidt B, Kretzschmar HA (1997) Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity. Exp Neurol 146: 104–112

    Article  PubMed  CAS  Google Scholar 

  • Burkitt MJ (2001) A critical overview of the chemistry of copper-dependent low density lipoprotein oxidation: Roles of lipid hydroperoxides, a-tocopherol, thiols, and ceruloplasmin. Arch Biochem Biophys 394: 117–135

    Article  PubMed  CAS  Google Scholar 

  • Cadenas E (2004) Mitochondrial free radical production and cell signaling. Mol Aspects Med 1–2: 17–26

    Article  CAS  Google Scholar 

  • Cassina AM, Hodara R, Souza JM et al. (2000) Cytochrome c nitration by peroxynitrite. J Biol Chem 275: 21409–21415

    Article  PubMed  CAS  Google Scholar 

  • Cawley GF, Batie CJ, Backes WL (1995) Substrate-dependent competition of different P450 isozymes for limiting NADPH-cytochrome P450 reductase. Biochem 34(4): 1244–1247

    Article  CAS  Google Scholar 

  • Cernuda-Morollon E, Pineda-Molina E, Canada FJ, Perez-Sala D (2001) 15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit. J Biol Chem 276: 35530–35536

    Article  PubMed  CAS  Google Scholar 

  • Chandel NS, Schumacker PT (2000) Cellular oxygen sensing by mitochondria: old questions, new insight. J Appl Physiol 88: 1880–1889

    Article  PubMed  CAS  Google Scholar 

  • Chen LJ, Yang XQ, Jiao H, Zhao B (2003) Tea catechins protect against lead-induced ROS formation, mitochondrial dysfunction, and calcium dysregulation in PC12 cells. Chem Res Toxicol 16: 1155–1161

    Article  PubMed  CAS  Google Scholar 

  • Chesis PL, Levin DE, Smith MT, Ernster L, Ames BN (1984) Mutagenicity of quinones: Pathway of metabolic activation and detoxification. Proc Natl Acad Sci USA 81: 1696–1700

    Article  PubMed  CAS  Google Scholar 

  • Chevion S, Chevion M (2000) Antioxidant status and human health. Use of cyclic voltammetry for the evaluation of the antioxidant capacity of plasma and of edible plants. In: Chiueh CC (ed) Reactive oxygen species: From radiation to molecular biology. A Festschrift in honor of Daniel L. Gilbert. Symposium proceedings. Bethesda, Maryland, USA 1998. Ann NY Acad Sci 899: S308–325

    Google Scholar 

  • Chevion S, Berry EM, Kitrossky N, Kohen R (1997) Evaluation of plasma low molecular weight antioxidant capacity by cyclic voltammetry. Free Radic Biol Med 22: 411–421

    Article  PubMed  CAS  Google Scholar 

  • Chevion S, Roberts M, Chevion M (2000) The use of cyclic voltammetry for the evaluation of antioxidant capacity. Free Radic Biol Med 28: 860–870

    Article  PubMed  CAS  Google Scholar 

  • Choi YB, Tenneti L, Le DA, Ortiz J, Bai G, Chen HS, Lipton SA (2000) Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nat Neurosci 3: 15–21

    Article  PubMed  CAS  Google Scholar 

  • Christen P, Jaussi P (2004) Biochemie. Springer, Berlin, S 472–475

    Google Scholar 

  • Claycombe KJ, Meydani SN (2001) Vitamin E and genome stability (Review). Mutation Res 475: 37–44

    PubMed  CAS  Google Scholar 

  • Clementi E, Brown GC, Feelisch M, Moncada S (1998) Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 95: 7631–7636

    Article  PubMed  CAS  Google Scholar 

  • Cooper CE (2002) Nitric oxide and cytochrome oxidase: Substrate, inhibitor or effector? Trends Biochem Sci 27: 33–39

    Article  PubMed  CAS  Google Scholar 

  • Cui K, Luo X, Xu K, Ven Murthy MR (2004) Role of oxidative stress in neurodegeneration: Recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Progr Neuro-Psychopharmacol Biol Psychiatry 28: 771–799

    Article  CAS  Google Scholar 

  • Daiber A, Ullrich V (2002) Stickstoffmonoxid, Superoxid und Peroxynitrit. Chemie Zeit 6: 366–375

    Google Scholar 

  • Dalle-Donne I, Giustarini D, Colombo R, Rossi R, Milzani A (2003) Protein carbonylation in human diseases. Trends Mol Med 9: 169–176

    Article  PubMed  CAS  Google Scholar 

  • Dalle-Donne I, Scaloni A, Giustarini D et al. (2005) Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redoxproteomics. Mass Spectrom Rev 24: 55–99

    Article  PubMed  CAS  Google Scholar 

  • Del Maestro RF (1980) An approach to free radicals in medicine and biology. Acta Physiol Scand Suppl 492: 153–168

    Google Scholar 

  • Delia Corte E, Stirpe F (1972) The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme. Biochem J 126: 739–745

    Google Scholar 

  • Denninger JW, Marietta MA (1999) Guanylate cyclase and the •NO/cGMP signaling pathway. Biochim Biophys Acta 1411: 334–350

    Article  PubMed  CAS  Google Scholar 

  • Denu JM, Tanner KG (1998) Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: Evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37: 5633–5642

    Article  PubMed  CAS  Google Scholar 

  • Exley C (2004) The pro-oxidant activity of aluminum. Free Radic Biol Med 36: 380–387

    Article  PubMed  CAS  Google Scholar 

  • Factor VM, Laskowska D, Jensen MR, Woitach JT, Popescu NC, Thorgeirsson SS (2000) Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Proc Natl Acad Sci USA 97: 52196–52201

    Article  Google Scholar 

  • Feng L, Xia Y, Garcia GE, Hwang D, Wilson CB (1995) Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor neccrosis factor-a, and lipopolysaccharide. J Clin Invest 95: 1669–1675

    Article  PubMed  CAS  Google Scholar 

  • Fenton HJH (1876) On a new reaction of tartaric acid. Chem News 33: 190

    Google Scholar 

  • Fenton HJH (1894) The oxidation of tartaric acid in presence of iron. J Chem Soc Proc 10: 157–158

    Google Scholar 

  • Fenton HJH (1896) Constitution of a new dibasic acid, resulting from the oxidation of tartaric acid. J Chem Soc Trans 69: 546–562

    Article  CAS  Google Scholar 

  • Fine AM (2000) Oligomeric proanthocyanidin complexes: History, structure, and phytopharmaceutical applications. Altern Med Rev 5: 144–151

    PubMed  CAS  Google Scholar 

  • Fortemaison N, Miot F, Dumont JE, Dremier S (2005) Regulation of H2O2 generation in thyroid cells does not involve Rac1 activation. Eur J Endocrin 152: 127–133

    Article  CAS  Google Scholar 

  • Frederiks WM, Vreeling-Sindelarova H (2002) Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells. Acta Histochem 104: 29–37

    Article  PubMed  CAS  Google Scholar 

  • Fridovich I (1983) Superoxide radical, an endogeneous toxicant. Ann Rev Pharmacol Toxicol 23: 239–257

    Article  CAS  Google Scholar 

  • Fukada K, Zhang F, Vien A, Cashman NR, Zhut H (2004) Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis. 3: 1211–1223

    CAS  Google Scholar 

  • Gershman R, Gilbert DL, Nye SW, Dwyer P, Fenn WO (1954) Oxygen poisoning and x-irradiation: a mechanism in common. Science 119: 623–626

    Google Scholar 

  • Ghezzi P, Bonetto V (2003) Redox proteomics: Identification of oxidatively modified proteins. Proteomics 3: 1145–1153

    Article  PubMed  CAS  Google Scholar 

  • Gilbert D (2000) Fifty years of radical ideas. In: Chiueh CC (ed) Reactive oxygen species: From radiation to molecular biology. A festschrift in honor of Daniel L. Gilbert. Symposium proceedings. Bethesda, Maryland, USA 1998. Ann NY Acad Sci 899: S 1–14

    Google Scholar 

  • Giustarini D, Rossi R, Milzani A, Colombo R, Dalle-Donne I (2004) S-Glutathionylation: From redox regulation of protein functions to human diseases. J Cell Mol Med 8: 201–212

    PubMed  CAS  Google Scholar 

  • Go YM, Patel RP, Maland MC, Park H, Beckman JS, Darley-Usmar VM, Jo H (1999) Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH(2)-terminal kinase. Am J Physiol 277: H1647–1653

    PubMed  CAS  Google Scholar 

  • Goldberg MA, Dunning SP, Bunn HF (1988) Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science 242: 1412–1425

    PubMed  CAS  Google Scholar 

  • Gonzalez FJ (2005) Role of cytochromes P450 in chemical toxicity and oxidative stress: Studies with CYP2E1. Mutation Res 569: 101–110

    PubMed  CAS  Google Scholar 

  • Groemping Y, Rittinger K (2005) Activation and assembly of NADPH oxidase: A structural perspective. Biochem J 386: 401–416

    Article  PubMed  CAS  Google Scholar 

  • Grosser N, Oberle S, Berndt G, Erdmann K, Hemmerle A, Schroder H (2004) Antioxidant action of L-alanine: heme oxygenase-1 and ferritin as possible mediators. Biochem Biophys Res Commun 314: 351–355

    Article  PubMed  CAS  Google Scholar 

  • Guaiquil VH, Golde DW, Beckles DL, Mascareno EJ, Siddiqui MAQ (2004) Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts. Free Radic Biol Med 37: 1419–1429

    Article  PubMed  CAS  Google Scholar 

  • Guittet O, Decottignies P, Serani L, Henry Y, Le Marechal P, Laprevote O, Lepoivre M (2000) Peroxynitrite-mediated nitration of the stable free radical tyrosine residue of the ribonucleotide reductase small subunit. Biochemistry 39: 4640–4648

    Article  PubMed  CAS  Google Scholar 

  • Guo W-X, Pye QN, Williamson KS et al. (2004) Reactive oxygen species in choline deficiency-induced apoptosis in rat hepatocytes. Free Radic Biol Med 37: 1081–1089

    Article  PubMed  CAS  Google Scholar 

  • Gutteridge JMC (1995) Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 41: 1819–1828

    PubMed  CAS  Google Scholar 

  • Gutteridge JMC, Halliwell B (2000) Free radicals and antioxidants in the year 2000. A historical look to the future. In: Chiueh CC (ed) Reactive oxygen species: From radiation to molecular biology. A festschrift in honor of Daniel L Gilbert. Symposium proceedings. Bethesda, Maryland, USA 1998. Ann NY Acad Sci 899: S 1–14

    Google Scholar 

  • Haber F, Weiss J (1934) The catalytic decomposition of hydrogen peroxide by iron salts. Proc R Soc Lond [A] 147: 332–351

    Article  CAS  Google Scholar 

  • Haber F, Willstätter R (1931) Unpaarigkeit und Radikalketten im Reaktionsmechanismus organischer und enzymatischer Vorgänge. Ber Deutsch Chem Ges 64: 2844–2856

    Google Scholar 

  • Halliwell B (1978) Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates: is it a mechanism for hydroxyl radical production in biochemical systems? FEBS Lett 92: 321–326

    Article  PubMed  CAS  Google Scholar 

  • Halliwell B (2001) Vitamin C and genomic stability (Review). Mutat Res 475: 29–35

    PubMed  CAS  Google Scholar 

  • Halliwell B, Gutteridge JMC (1990) The antioxidants of human extracellular fluids. Arch Biochem Biophys 280: 1–8

    Article  PubMed  CAS  Google Scholar 

  • Halliwell B, Gutteridge JMC (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219: 1–14

    PubMed  CAS  Google Scholar 

  • Hamilton CA, Miller WH, Al-Benna S, Brosnan MJ, Drummond RD, McBride MW, Dominiczak AF (2004) Strategies to reduce oxidative stress in cardiovascular disease. Clin Sci 106: 219–234

    Article  PubMed  CAS  Google Scholar 

  • Harman D (2001) Aging: Overview. Ann NY Acad Sci 928: 1–21

    Article  PubMed  CAS  Google Scholar 

  • Harman SM, Liang L, Tsitouras PD et al. (2003) Urinary excretion of three nucleic acid oxidation adducts and isoprostane F2α measured by liquid chromatography mass spectrometry in smokers, ex-smokers, and nonsmokers. Free Radic Biol Med 35: 1301–1309

    Article  PubMed  CAS  Google Scholar 

  • Hayden MR, Tyagi SC (2004) Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle. Nutr Metab (Lond) 1: 10

    Article  CAS  Google Scholar 

  • Hensley K, Floyd RA (2002) Reactive oxygen species and protein oxidation in aging: A look back, a look ahead. Arch Biochem Biophys 397: 377–383

    Article  PubMed  CAS  Google Scholar 

  • Hoang DQ, Pfefferkorn LC (1998) Strategies 11: 1–2

    Google Scholar 

  • Hochstein P, Ernster L (1963) ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes. Biochem Biophys Res Commun 12: 388–394

    Article  PubMed  CAS  Google Scholar 

  • Il’Yasova D, Morrow JD, Ivanova A, Wagenknecht LE (2004) Epidemiological marker for oxidant status: comparison of the ELISA and the gas chromatography/mass spectrometry assay for urine 2,3-dinor-5,6-dihydro-15-F2t-isoprostane. Ann Epidemiol 14: 793–797

    Article  PubMed  Google Scholar 

  • Inoue M, Sato EF, Nishikawa M, Park AM, Kira Y, Imada I und Utsumi K (2003) Mitochondrial generation of reactive oxygen species and its role in aerobic life. Curr Medic Chem 10: 2495–2505

    Article  CAS  Google Scholar 

  • Jakóbisiak M, Lasek W, Golab J (2003) Natural mechanisms protecting against cancer. Immunol Letters 90: 103–122

    Article  CAS  Google Scholar 

  • Jones OTG, Hancock JT (2000) NADPH oxidase of neutrophils and other cells. In: Winyard PG, Blake DR, Evn CH (eds) Free radicals in inflammation. Birkhäuser, Basel, pp 21–46

    Google Scholar 

  • Kaminsky LS, Guengerich FP (1985) Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin. Eur J Biochem 149: 479–489

    Article  PubMed  CAS  Google Scholar 

  • Karnovsky ML, Bishop A, Camerero VC, Paz MA, Colepicolo P, Ribeiro JM, Gallop PM (1994) Aspects of the release of superoxide by leukocytes, and a means by which this is switched off. Environ Health Perspect 102Suppl 10: 43–44

    PubMed  CAS  Google Scholar 

  • Kim JY, Mukherjee S, Ngo L, Christiani DC (2004) Urinary 8-hydroxy-2′-deoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to fine particulates. Environ Health Perspect 112: 666–670

    Article  PubMed  CAS  Google Scholar 

  • Kim PK, Kwon YG, Chung HT, Kim YM (2002 a) Regulation of caspases by nitric oxide. Ann NY Acad Sci 962: 42–52

    PubMed  CAS  Google Scholar 

  • Kim SO, Merchant K, Nudelman R et al. (2002 b) OxyR: A molecular code for redox-related signaling. Cell 109: 383–396

    Article  PubMed  CAS  Google Scholar 

  • Klatt P, Lamas S (2000) Regulation of protein function by Sgluathiolation in response to oxidative and nitrosative stress. Eur J Biochem 267: 4928–4944

    Article  PubMed  CAS  Google Scholar 

  • Klötzli F (1980) Unsere Welt und wir. Hallwag, Bern

    Google Scholar 

  • Kobayashi M, Yamamoto M (2005) Molecular mechanisms activating the Nrf2-Keapl pathway of antioxidant gene regulation. Antioxid Redox Signal 7: 385–394

    Article  PubMed  CAS  Google Scholar 

  • Koppenol WH (2001) The Haber-Weiss cycle — 70 years later. Redox Rep 6: 229–234

    Article  PubMed  CAS  Google Scholar 

  • Kretzschmar HA, Tings T, Madlung A, Giese A, Herms J (2000) Function of PrP(C) as a copper-binding protein at the synapse. Arch Virol Suppl (16): 239–249

    PubMed  Google Scholar 

  • Kröncke KD, Klotz LO, Suschek CV, Sies H (2002) Comparing nitrosative versus oxidative stress towards zinc finger-dependent transcription. Unique role for NO. J Biol Chem 277: 13294–13301

    Article  PubMed  CAS  Google Scholar 

  • Kuhn DM, Sadidi M, Liu X, Kreipke C, Geddes T, Borges C, Watson JT (2002) Peroxynitrite-induced nitration of tyrosine hydroxylase: Identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis. J Biol Chem 277: 14336–14342

    Article  PubMed  CAS  Google Scholar 

  • Kurz T, Leake A, Zglinicki T von, Brunk UT (2004) Lysosomal redox-active iron is important for oxidative stress-induced DNA damage. Ann NY Acad Sci 1019: 285–288

    Article  PubMed  CAS  Google Scholar 

  • Landriscina C, Petragallo V, Morini P, Marcotrigiano GO (1988) Lipid peroxidation in rat liver microsomes. I. Stimulation of the NADPH-cytochrome P-450 reductase-dependent process in hyperthyroid state. Biochem Int 17: 385–393

    PubMed  CAS  Google Scholar 

  • Lawrenson JG (2003) Age-related cataract. Epidemiology, pathogenesis and management. Contin Profession Dev OT 24–29

    Google Scholar 

  • Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW (1999) Hydroxyl radical generation during exercise increase mitochondrial protein oxidation and levels of urinary dityrosine. Free Radic Biol Med 27: 186–192

    Article  PubMed  CAS  Google Scholar 

  • Levy AP, Levy NS, Loscalzo J et al. (1995) Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res 76: 758–766

    PubMed  CAS  Google Scholar 

  • Lin T-K, Hughes G, Muratovska A et al. (2002) Specific modification of mitochondrial protein thiols in response to oxidative stress. J Biol Chem 277: 17048–17056

    Article  PubMed  CAS  Google Scholar 

  • Liochev SI, Fridovich I (2002) Correspondence: The Haber-Weiss cycle — 70 years later: An alternative view. Redox Report 7: 55–57

    Article  PubMed  CAS  Google Scholar 

  • Liu H, Wang, H, Shenvi S, Hagen TM, Liu R-M (2004) Glutathione metabolism during aging and in Alzheimer disease. Ann NY Acad Sci 1019: 346–349

    Article  PubMed  CAS  Google Scholar 

  • Liu D, Wen J, Liu J, Li L (1999 a) The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids. FASEB 13: 2318–2328

    CAS  Google Scholar 

  • Liu KJ, Kotake Y, Lee M, Miyake M, Sugden K, Yu Z, Swartz HM (1999b) High-performance liquid chromatography study of the pharmacokinetics of various spin traps for application to in vivo spin trapping. Free Radic Biol Med 27: 82–89

    Article  PubMed  CAS  Google Scholar 

  • Liu Q, Raina AK, Smith MA, Sayre LM, Perry G (2003) Hydroxynonenal, toxic carbonyls, and Alzheimer disease. Mol Aspects Med 24: 305–313

    Article  PubMed  CAS  Google Scholar 

  • MacMillan-Crow LA, Thompson JA (1999) Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. Arch Biochem Biophys 366: 82–88

    Article  PubMed  CAS  Google Scholar 

  • Marks A, Smith C, Lieberman M (2005) Basic medical biochemistry, 2nd edn. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  • Mattill HA (1941) Fat-soluble vitamins. Ann Rev Biochem 10: 395–422

    Article  CAS  Google Scholar 

  • McCord JM, Day Jr ED (1978) Superoxide-dependent production of hydroxyl radical catalyzed by the iron-EDTA complex. FEBS Lett 86: 139–142

    Article  PubMed  CAS  Google Scholar 

  • McCord JM, Fridovich I (1969 a) Superoxide dismutase. An enzymic function for erythrocuprein (haemocuprein). J Biol Chem 244: 6049–6055

    PubMed  CAS  Google Scholar 

  • McCord JM, Fridovich I (1969b) The utility of superoxide dismutase in studying free radical reactions. I. Radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. J Biol Chem 244: 6056–6063

    PubMed  CAS  Google Scholar 

  • Mohazzab KM, Kaminski PM, Wolin MS (1994) NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am J Physiol 266: H2568–H2572

    PubMed  CAS  Google Scholar 

  • Moskovitz J (2005) Roles of methionine sulfoxide reductases in antioxidant defense, protein regulation ansd survival. Curr Pharm Des 11: 1451–1457

    Article  PubMed  CAS  Google Scholar 

  • Mostertz J, Hecker M (2003) Patterns of protein carbonylation following oxidative stress in wild-type and sigB Bacillus subtilis cells. Mol Gen Genomics 269: 640–648

    Article  CAS  Google Scholar 

  • Mouillet-Richard S, Ermonval M, Chebassier C, Laplanche JL, Lehmann S, Launay JM, Kellermann O (2000) Signal transduction through prion protein. Science 289: 1925–1928

    Article  PubMed  CAS  Google Scholar 

  • Nathan CF, Hibbs JB (1991) Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 3: 65–70

    Article  PubMed  CAS  Google Scholar 

  • National Academy of Sciences, Institute of Medicine (2000) Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids: A report of the Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and on Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on Scientific Evaluation of Dietary Reference Intakes. Food and Nutrition Board, Institute of Medicine. National Academy Press, Washington, DC, p 17

    Google Scholar 

  • Nishino T, Nishino T (1997) The conversion from dehydrogenase type to oxidase type of rat liver xanthine dehydrogenase by modification of cysteine residues with fluorodinitrobenzene. J Biol Chem 272: 29859–29864

    Article  PubMed  CAS  Google Scholar 

  • Ohlmann A, Giffhorn-Katz S, Becker I, Katz N, Immenschuh S (2003) Regulation of heme-oxygenase-1 gene expression by anoxia and reoxygenation in primary rat hepatocyte cultures. Exp Biol Med 228: 584–589

    CAS  Google Scholar 

  • Okamoto K, Eger BT, Nishino T, Kondo S, Pai EF, Nishino T (2003) An extremely potent inhibitor of xanthine oxidoreductase. J Biol Chem 278: 1848–1855

    Article  PubMed  CAS  Google Scholar 

  • Oliva JL, Perez-Sala D, Castrillo A, Martinez N, Canada FJ, Bosca L, Rojas JM (2003) The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. Proc Natl Acad Sci USA 100: 4772–4777

    Article  PubMed  CAS  Google Scholar 

  • Paolini M, Valgimigli L, Marchesi E, Trespidi S, Pedulli GF (2003) Taking EPR „snapshots“ of the oxidative stress status in human blood. Free Radic Res 37(5): 503–508

    Article  PubMed  CAS  Google Scholar 

  • Piconi L, Quagliaro L, Ceriello A (2003) Oxidative stress in diabetes. Clin Chem Lab Med 41: 1144–1149

    Article  PubMed  CAS  Google Scholar 

  • Pucheu S, Coudray C, Vanzetto G, Favier A, Machecourt J, de Leiris J (1995) Assessment of radical activity during the acute phase of myocardial infarction following fibrinolysis. Utility of assaying plasma malondialdehyde. Free Radic Biol Med 19: 873–881

    Article  PubMed  CAS  Google Scholar 

  • Rahman I, Marwick J, Kirkham P (2004) Redox modulation of chromatin remodeling: Impact on histone acetylation and deacetylation, NF-κB and pro-inflammatory gene expression. Biochem Pharmacol 68: 1255–1267

    Article  PubMed  CAS  Google Scholar 

  • Rathaus M, Bernheim J (2002) Oxygen species in the micro-vascular environment: Regulation of vascular tone and the development of hypertension. Nephrol Dial Transplant 17: 216–221

    Article  PubMed  Google Scholar 

  • Recknagel RO, Ghoshal AK (1966) Quantitative estimation of peroxidative degeneration of rat liver microsomal and mitochondrial lipids after carbon tetrachloride poisoning. Exp Mol Pathol 5: 413–426

    Article  PubMed  CAS  Google Scholar 

  • Ren W, Qiao Z, Wang H, Zhu L, Zhang L (2003) Flavonoids: Promising anticancer agents. Med Res Rev 23: 519–534

    Article  PubMed  CAS  Google Scholar 

  • Rhee SG, Bae YS, Lee SR, Kwon J (2000) Hydrogen peroxide: A key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE 2000: PE1

    Google Scholar 

  • Richardson T, Tappel AL, Smith LM, Houle CR (1962) Polyunsaturated fatty acids in mitochondria. J Lipid Research 3: 344–350

    CAS  Google Scholar 

  • Rioux N, Castonguay A (2000) The induction of cyclooxy-genase-1 by a tobacco carcinogen in U937 human macrophages is correlated to the activation of NF-κB. Carcinogenesis 21: 1745–1751

    Article  PubMed  CAS  Google Scholar 

  • Roberts II LJ, Fessel JP (2004) The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation. Chem Phys Lipids 128: 173–186

    Article  PubMed  CAS  Google Scholar 

  • Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG (2000) Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403: 103–108

    Article  PubMed  CAS  Google Scholar 

  • Rossig L, Dimmeler S, Zeiher AM (2001) Apoptosis in the vascular wall and atherosclerosis. Basic Res Cardiol 1: 11–22

    Google Scholar 

  • Rubbo H, Radi R, Trujillo M et al. (1994) Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem 269(42): 26066–26075

    PubMed  CAS  Google Scholar 

  • Santoni-Rugiu E, Jensen MR, Factor VM, Thorgeirsson SS (1999) Acceleration of c-myc-induced hepatocarcinogenesis by Co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption. Am J Pathol 154: 1693–1700

    PubMed  CAS  Google Scholar 

  • Sargent LM, Sanderson ND, Thorgeirsson SS (1996) Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes. Cancer Res 56: 2137–2142

    PubMed  CAS  Google Scholar 

  • Sauer H, Wartenberg M, Hescheler J (2001) Reactive oxygen species and intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 11: 173–186

    Article  PubMed  CAS  Google Scholar 

  • Sauer H, Wefer K, Vetrugno V et al. (2003) Regulation of intrinsic prion protein by growth factors and TNF-alpha: The role of intracellular reactive oxygen species. Free Radic Biol Med 35: 586–594

    Article  PubMed  CAS  Google Scholar 

  • Sawamura AO, Aoyama T, Tamakoshi K, Mizuno K, Suganuma N, Kikkawa F, Tomoda Y (1996) Transfection of human cytochrome P-450 reductase cDNA and its effect on the sensitivity to toxins. Oncology 53: 406–411

    Article  PubMed  CAS  Google Scholar 

  • Schaur RJ (2003) Basic aspects of the biochemical reactivity of 4-hydroxynonenal. Mol Aspect Med 24: 149–159

    Article  CAS  Google Scholar 

  • Schildknecht H, Holubek K (1961) Die Bombardierkäfer und ihre Explosionschemie. Angew Chem 73: 1–7

    Google Scholar 

  • Schmidt P, Youhnovski N, Daiber A et al. (2003) Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase. J Biol Chem 278: 12813–12819

    Article  PubMed  CAS  Google Scholar 

  • Schmitt-Ulms G, Legname G, Baldwin MA et al. (2001) Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. J Mol Biol 314: 1209–1225

    Article  PubMed  CAS  Google Scholar 

  • Schrammel A, Gorren AC, Schmidt K, Pfeiffer S, Mayer B (2003) S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-). Free Radic Biol Med 34: 1078–1088

    Article  PubMed  CAS  Google Scholar 

  • Sell A (2001) Differenzierung mitochondrialer und nicht-mitochondrialer Quellen von reaktiven Sauerstoffspezies in PC12-Zellen unter Hypoxie. Dissertation, Justus-Liebig-Universität Gießen, Fachbereich Veterinärmedizin

    Google Scholar 

  • Shapiro GI (2004) Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol. Clin Canc Res 10: 4270S–4275S

    Article  CAS  Google Scholar 

  • Shern-Brewer R, Santanam N, Wetzstein C, White-Welkley J, Parthasarathy S (1998) Exercise and cardiovascular disease: A new perspective. Arterioscler Thromb Vasc Biol 18(7): 1181–1187

    PubMed  CAS  Google Scholar 

  • Shibata T, Yamada T, Ishii T et al. (2003) Thioredoxin as a molecular target of cyclopentenone prostaglandins. J Biol Chem 278: 26046–26054

    Article  PubMed  CAS  Google Scholar 

  • Sies H (1999) Glutathione and its role in cellular functions. Free Radic Biol Med 27: 916–921

    Article  PubMed  CAS  Google Scholar 

  • Shiva S, Moellering D, Ramachandran A et al. (2004) Redox signalling: From nitric oxide to oxidized lipids. Biochem Soc Symp:71:107–120

    PubMed  CAS  Google Scholar 

  • Smith RM, Mohideen P (1991) One hour in 1 ATA oxygen enhances rat alveolar macrophage chemiluminescence and fungal cytotoxicity. Am J Physiol 260: L457–463

    PubMed  CAS  Google Scholar 

  • Stadtman ER, Van Remmen H, Richardson A, Wehr NB, Levine RL (2005) Methionine oxidation and aging. Biochim Biophys Acta 1703: 135–140

    PubMed  CAS  Google Scholar 

  • Stamler JS, Jia L, Eu JP et al. (1997) Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 276: 2034–2037

    Article  PubMed  CAS  Google Scholar 

  • Stevnsnera T, Thorslunda T, de Souza-Pintob NC, Bohra VA (2002) Mitochondrial repair of 8-oxoguanine and changes with aging. Exp Gerontol 37: 1189–1196

    Article  Google Scholar 

  • Stirpe F, Delia Corte E (1969) The regulation of rat liver xanthine oxidase. Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O). J Biol Chem 244: 3855–3863

    PubMed  CAS  Google Scholar 

  • Straus DS, Pascual G, Li M et al. (2000) 15-Deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci USA 97: 4844–4849

    Article  PubMed  CAS  Google Scholar 

  • Strobel HW, Kawashima H, Geng J et al. (1995) Expression of multiple forms of brain cytochrome P450. Toxicol Lett 82–83: 639–643

    Article  PubMed  Google Scholar 

  • Tauber AI, Borregaard N, Simons E, Wright J (1983) Chronic granulomatous disease: A syndrome of phagocyte oxidase deficiencies. Medicine 62: 286–309

    PubMed  CAS  Google Scholar 

  • Thannickal VJ, Fanburg BL (2000) Reactive oxygen species in cell signalling. Am J Physiol Lung Cell Mol Physiol 279: L1005–L1028

    PubMed  CAS  Google Scholar 

  • Thiede B, Rudel T (2004) Proteome analysis of apoptotic cells. Mass Spectrom Rev 23: 333–349

    Article  PubMed  CAS  Google Scholar 

  • Valgimigli L, Pedulli GF, Paolini M (2001) Measurement of oxidative stress by EPR radical-probe technique. Free Radic Bio Med 31: 708–716

    Article  CAS  Google Scholar 

  • Vester F (1978) Das Überlebensprogramm. Fischer Taschenbuch Verlag, Frankfurt

    Google Scholar 

  • Vincent AM, Russell JW, Low P, Feldman EL (2004) Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev 25: 612–628

    Article  PubMed  CAS  Google Scholar 

  • Wang Y, Vivekananda S, Men L, Zhang Q (2004) Fragmentation of protonated ions of peptides containing cysteine, cysteine sulfinic acid, and cysteine sulfonic acid. J Am Soc Mass Spectrom 15: 697–702

    Article  PubMed  CAS  Google Scholar 

  • Waxman DJ, Morrissey JJ, LeBlanc GA.(1989) Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms. Endocrinology 124: 2954–2966

    Article  PubMed  CAS  Google Scholar 

  • Werz O, Szellas D, Steinhilber D (2000) Reactive oxygen species released from granulocytes stimulate 5-lipoxygenase activity in a B-lymphocytic cell line. Eur J Biochem 267: 1263–1269

    Article  PubMed  CAS  Google Scholar 

  • White CR, Brock TA, Chang LY et al. (1994) Superoxide and peroxynitrite in artherosclerosis. Proc Natl Acad Sci USA 91: 1044–1048

    Article  PubMed  CAS  Google Scholar 

  • Wu LL, Chiou C-C, Chang P-Y, Wu JT (2004) Urinary 8-OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta 339: 1–9

    Article  PubMed  CAS  Google Scholar 

  • Xu L, Eu JP, Meissner G, Stamler JS (1998) Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 279: 234–237

    Article  PubMed  CAS  Google Scholar 

  • Yang Y, Sharma R, Sharma A, Awasthi S, Awasthi YC (2003) Lipid peroxidation and cell cycle signaling: 4-hydroxyno-nena1, a key molecule in stress mediated signaling. Acta Bioch Pol 50: 319–336

    CAS  Google Scholar 

  • Yao Y, Yin D, Jas GS, Kuczer K, Williams TD, Schoneich C, Squier TC (1996) Oxidative modification of a carboxyl-terminal vicinal methionine in calmodulin by hydrogen peroxide inhibits calmodulin-dependent activation of the plasma membrane Ca-ATPase. Biochemistry 35: 2767–2787

    Article  PubMed  CAS  Google Scholar 

  • Yeum KJ, Russell RM, Krinsky NI, Aldinic G (2004) Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys 430: 97–103

    Article  PubMed  CAS  Google Scholar 

  • Zafarullah M, Li WQ, Sylvester J, Ahmad M (2003) Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60: 6–20

    Article  PubMed  CAS  Google Scholar 

  • Zagórska A, Dulak J (2004) HIF-1: The knowns and unknowns of hypoxia sensing. Acta Biochim Pol 51: 563–585

    PubMed  Google Scholar 

  • Zhang H, Means GE (1996) S-nitrosation of serum albumin: Spectrophotometric determination of its nitrosation by simple S-nitrosothiols. Anal Biochem 237: 141–144

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Oncology Business Unit, Novartis Pharma AG, Klybeckstraße 141, 4057, Basel, Schweiz

    Dr. Ulrike Pfaar

  2. Hochschule für Life Sciences, Institut für Chemie und Bioanalytik, Gründenstraße 40, 4132, Muttenz, Schweiz

    Dr. Eric Kübler

  3. Hochschule für Life Sciences, Präsident Swiss Biotechnet, Institut für Chemie und Bioanalytik, Gründenstraße 40, 4132, Muttenz, Schweiz

    Prof. Dr. Daniel Gygax

Authors
  1. Dr. Ulrike Pfaar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. Eric Kübler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Prof. Dr. Daniel Gygax
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Charité — Universitätsmedizin Berlin, Schumannstr. 20/21, 10117, Berlin

    Detlev Ganten (Der Vorstandsvorsitzende (CEO) (Der Vorstandsvorsitzende (CEO)

  2. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10, 13122, Berlin-Buch

    Klaus Ruckpaul

  3. Charité Campus Mitte Institut für Experimentelle Endokrinologie, Charité — Universitätsmedizin Berlin, Schumannstraße 20/21, 10117, Berlin

    Josef Köhrle

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Pfaar, U., Kübler, E., Gygax, D. (2006). Molekulare Regulation der Bildung und Inaktivierung reaktiver Sauerstoffspezies. In: Ganten, D., Ruckpaul, K., Köhrle, J. (eds) Molekularmedizinische Grundlagen von para- und autokrinen Regulationsstörungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28782-5_7

Download citation

Publish with us

Policies and ethics

Search

Navigation