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Structure and Applications of Poly(vinyl alcohol) Hydrogels Produced by Conventional Crosslinking or by Freezing/Thawing Methods

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Biopolymers · PVA Hydrogels, Anionic Polymerisation Nanocomposites

Part of the book series: Advances in Polymer Science ((POLYMER,volume 153))

Abstract

Poly(vinyl alcohol) (PVA) is a polymer of great interest because of its many desirable characteristics specifically for various pharmaceutical and biomedical applications. The crystalline nature of PVA has been of specific interest particularly for physically cross-linked hydrogels prepared by repeated cycles of freezing and thawing. This review includes details on the structure and properties of PVA, the synthesis of its hydrogels, the crystallization of PVA, as well as its applications. An analysis of previous work in the development of freezing and thawing processes is presented focusing on the implications of such materials for a variety of applications. PVA blends that have been developed with enhanced properties for specific applications will also be discussed briefly. Finally, the future directions involving the further development of freeze/thawed PVA hydrogels are addressed.

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References

  1. Tubbs RK (1966) J Polym Sci A1 4:623

    Article  CAS  Google Scholar 

  2. Finch CA (1973) Poly(vinyl alcohol): properties and applications. Wiley, New York

    Google Scholar 

  3. Peppas NA (1987) Hydrogels in medicine and pharmacy, vol 1, Polymers. CRC Press, Boca Raton, FL

    Google Scholar 

  4. Peppas NA (1987). In: Peppas, NA (ed) Hydrogels in medicine and pharmacy, vol 2, Polymers. CRC, Boca Raton, FL, pp 1–48.

    Google Scholar 

  5. Danno A (1958) J Phys Soc Jpn 13:722

    Article  CAS  Google Scholar 

  6. Saito O (1959) J Phys Soc Jpn 14:792

    Article  CAS  Google Scholar 

  7. Dieu J, Desreux V (1959) Large Radiation Sources in Industry 1:341

    Google Scholar 

  8. Sakurada I, Mori N (1959) Seni Gakkaishi 15:948

    Google Scholar 

  9. Peppas NA, Merrill EW (1976) J Appl Polym Sci 20:1457

    Article  CAS  Google Scholar 

  10. Bray JC, Merrill EW (1973) J Appl Polym Sci 17:3781

    Article  CAS  Google Scholar 

  11. Peppas NA, Merrill EW (1974) Techn Chron 43:559

    Google Scholar 

  12. Peppas NA, Merrill EW (1976) J Polym Sci Polym Chem Ed 14:441

    Article  CAS  Google Scholar 

  13. Stauffer SR, Peppas NA (1992) Polymer 33:3932

    Article  CAS  Google Scholar 

  14. Bunn CW (1948) Nature 161:929

    Article  CAS  Google Scholar 

  15. Flory PJ (1953) Principles of polymer chemistry. Cornell University Press, Ithaca, NY

    Google Scholar 

  16. Keller A (1957) Philos Mag 2:1171

    Article  CAS  Google Scholar 

  17. Mandelkern L (1967) J Polym Sci C18:51

    Google Scholar 

  18. Harris HE, Kenney JF, Willcockson GW, Chiang, R, Friedlander, HN (1966) J Polym Sci A14:665

    Google Scholar 

  19. Fujii K (1973) In: Finch, CA (ed) PVA-properties and applications. Wiley, New York, pp 203–231

    Google Scholar 

  20. Peppas NA (1976) Eur Polym J 12:495

    Article  CAS  Google Scholar 

  21. Peppas NA (1976) Org Coat Plast Chem Prepr 36:541

    Google Scholar 

  22. Peppas NA (1977) In: Labana SS (ed) Chemistry and properties of crosslinked polymers. Academic Press, New York, pp 469–478

    Google Scholar 

  23. Peppas NA, Hansen PJ (1982) J Appl Polym Sci 27:4787

    Article  CAS  Google Scholar 

  24. Mallapragada SK, Peppas NA (1996) J Polym Sci 34:1339

    CAS  Google Scholar 

  25. Yamaura K, Suzuki M, Yamamoto M, Shimada R, Tanigami T (1995) J Appl Polym Sci 58:1787

    Article  CAS  Google Scholar 

  26. Yamaura K, Kitahara H, Tanigami T (1997) J Appl Polym Sci 64:1283

    Article  CAS  Google Scholar 

  27. Yamaura K, Ideguchi S, Tanigami, T (1998) J Appl Polym Sci 70:1661

    Article  CAS  Google Scholar 

  28. Sone Y, Hirabayashi, K, Sakurada I (1953) Kobunshi Kagaku 10:7

    CAS  Google Scholar 

  29. Tanigami T, Nakashima Y, Murase K, Suzuki H, Yamaura K, Matsuzawa S (1995) J Mater Sci 30:5110

    Article  CAS  Google Scholar 

  30. Tanigami T, Yano K, Yamaura K, Matsuzawa S (1995) Polymer 36:2941

    Article  CAS  Google Scholar 

  31. Tanigami T, Murase K, Yamaura K, Matsuzawa S (1994) Polymer 35:2573

    Article  CAS  Google Scholar 

  32. Tanigami T, Yano K, Yamaura K, Matsuzawa S (1995) Polymer 36:2941

    Article  CAS  Google Scholar 

  33. Sakurada I, Nukushina Y, Sone Y (1955) Kobunshi Kagaku 12:510

    CAS  Google Scholar 

  34. Tadokoro H, Nagai J, Seki S, Nitta I (1961) Bull Chem Soc Jpn 34:1504

    Article  CAS  Google Scholar 

  35. Peppas NA (1977) Makromol Chem 178:595

    Article  CAS  Google Scholar 

  36. Peppas NA, Stauffer SR (1991) J Controlled Release 16:305

    Article  CAS  Google Scholar 

  37. Lozinsky VI (1998) Russian Chem Rev 67:573

    Article  Google Scholar 

  38. Peppas NA (1975) Makromol Chem 176:3433

    Article  CAS  Google Scholar 

  39. Nambu M (1984) US Patent 4,472,542

    Google Scholar 

  40. Nishinari K, Watase M, Ogino K, Nambu M (1983) Polymer Commun 24:345

    CAS  Google Scholar 

  41. Mano I, Goshima H, Nambu M, Iio M (1986) Magn Reson Med 3:921–926

    Article  CAS  Google Scholar 

  42. Yokoyama F, Masada I, Shimamura K, Ikawa T, Monobe K (1986) Colloid Polym Sci 264:595

    Article  CAS  Google Scholar 

  43. Watase M, Nishinari K (1985) J Appl Polym Sci Polym Phys Ed 23:1803

    Article  CAS  Google Scholar 

  44. Watase M, Nishinari K (1989) Makromol Chem 190:155

    Article  CAS  Google Scholar 

  45. Hyon SH, Ikada Y (1987) US Patent 4,663,358

    Google Scholar 

  46. Hyon SH, Cha WI, Ikada Y (1989) Kobunshi Ronbunshu 46:673

    CAS  Google Scholar 

  47. Berghmans H, Stoks W (1986) In: Kleintjes LA, Lemstra, PJ (eds) Integration of fundamental polymer science and technology. Elsevier, London, pp 218–229

    Google Scholar 

  48. Lozinsky VI, Domotenko LV, Vainerman ES, Mamtsis AM, Rogozhin SV (1986) Polym Bull 15:333

    Article  Google Scholar 

  49. Lozinsky VI, Zubov AL, Kulakova VK, Titova EF, Rogozhin SV (1992) J Appl Polym Sci 44:1423

    Article  Google Scholar 

  50. Lozinsky VI, Solodova EV, Zubov AL, Simenel IA (1995) J Appl Polym Sci 58:171

    Article  CAS  Google Scholar 

  51. Lozinsky VI, Domotenko LV, Zubov AL, Simenel IA (1996) J Appl Polym Sci 61:1991

    Article  CAS  Google Scholar 

  52. Urushizaki F, Yamaguchi H, Mizumachi H (1986) Yakugaku Zasshi 106:491

    CAS  Google Scholar 

  53. Urushizaki F, Yamaguchi H, Nakamura K, Numajiri S, Sugibayashi K, Morimoto Y (1990) Int J Pharm 58:135

    Article  CAS  Google Scholar 

  54. Ohkura M, Kanaya T, Kaji K (1992) Polymer 33:3686

    Article  CAS  Google Scholar 

  55. Ohkura M, Kanaya T, Kaji K (1992) Polymer 33:5044

    Article  CAS  Google Scholar 

  56. Kanaya T, Ohkura M, Kaji K (1994) Macromolecules 27:5609

    Article  CAS  Google Scholar 

  57. Kanaya T, Ohkura M, Takeshita H, Kaji K (1995) Macromolecules 28:3168

    Article  CAS  Google Scholar 

  58. Takeshita H, Kanaya T, Nishida K, Kaji K, Imai, M (1995) Polym Prepr Jpn (Engl Ed) 44:139

    Google Scholar 

  59. Hatakeyama T, Yamauchi A, Hatakeyama H (1987) Eur Polym J 23:361

    Article  CAS  Google Scholar 

  60. Cha WI, Hyon SH, Ikada Y (1993) Makromol Chem 194:2433

    Article  CAS  Google Scholar 

  61. Murase K, Tanigami T, Yamaura K, Matsuzawa S (1991) Polym Prepr Jpn (Engl Ed) 40:952

    Google Scholar 

  62. Trieu HH, Qutubuddin S (1994) Colloid Polym Sci 272:301

    Article  CAS  Google Scholar 

  63. Tazaki M, Kida T, Homma T (1989) Kobunshi Ronbunshu 46:733

    CAS  Google Scholar 

  64. Suzuki M, Matsuzawa M, Saito K (1991) Polym Prepr Jpn (Engl Ed) 40:953

    Google Scholar 

  65. Suzuki M, Tateishi T, Matsuzawa M, Saito K (1996) Macromol Symp 109:55

    Google Scholar 

  66. Bao QB, Higham PA (1991) US Patent 5,047,055

    Google Scholar 

  67. Takamura A, Arai M, Ishii F (1987) Yakugaku Zasshi 107:233

    CAS  Google Scholar 

  68. Takamura A, Ishii, F (1991) Yakugaku Zasshi 111:45

    CAS  Google Scholar 

  69. Takamura A, Ishii F, Hidaka H (1992) J Controlled Release 20:21

    Article  CAS  Google Scholar 

  70. Hyon SH, Cha WI, Oka M, Ikada Y (1993) Polym Prepr Jpn (Engl Ed) 42

    Google Scholar 

  71. Peppas NA (1996) Proc Topical Conf Process Structure Prep Polym Materials 1:321

    Google Scholar 

  72. Peppas NA, Scott JE (1992) J Controlled Release 18:95

    Article  CAS  Google Scholar 

  73. Ficek BJ, Peppas NA (1993) J Controlled Release 27:259

    Article  CAS  Google Scholar 

  74. Ficek BJ, Peppas NA (1994) In: Mikos AG, Murphy R, Bernstein H, Peppas NA (eds) Biomaterials for drug and cell delivery. Materials Research Society, Pittsburgh, PA, pp 223–226.

    Google Scholar 

  75. Hickey AS, Peppas NA (1995) J Membr Sci 107:229

    Article  CAS  Google Scholar 

  76. Peppas NA, Mongia NK (1997) Eur J Pharm Biopharm 43:51

    Article  CAS  Google Scholar 

  77. Peppas NA, Mongia N, Luttrell AS (1995) Proc World Meeting APGI/APV 1:817

    Google Scholar 

  78. Peppas NA, Anseth KS, Mongia NK (1996) Trans World Biomat Congress 5:643

    Google Scholar 

  79. Mongia NK, Anseth KS, Peppas NA (1996) J Biomat Sci Polym Ed 7:1055

    Article  CAS  Google Scholar 

  80. Luttrell AS, Mongia NK, Peppas NA (1994) Abstr AIChE Meeting 202c

    Google Scholar 

  81. Peppas NA, Borcherding ASL (1996) Proc Int Symp Control Rel Bioact Mater 23:145–146

    Google Scholar 

  82. Peppas NA, Mongia NK, Bugert CA (1996) Proc Int Symp Control Rel Bioact Mater 23:157

    Google Scholar 

  83. Hassan CM, Peppas NA (1998) Polym Mater Sci Eng Proc 79:473

    CAS  Google Scholar 

  84. Hassan CM, Trakarnpan P, Peppas NA (1998) In: Amjad Z (ed) Water soluble polymers: solution properties and applications. Plenum Press, New York, pp 31–40

    Google Scholar 

  85. Hassan CM, Peppas NA (1998) Proc Int Symp Control Rel Bioact Mater 25:50

    Google Scholar 

  86. Mallapragada SK, Peppas NA (1995) Polym Mater Sci Eng Proc 73:22

    CAS  Google Scholar 

  87. Mallapragada SK, Peppas NA (1997) AIChE J 43:870

    Article  CAS  Google Scholar 

  88. Mallapragada SK, Peppas NA (1997) J Controlled Release 45:87

    Article  CAS  Google Scholar 

  89. Mallapragada SK, Peppas NA, Colombo P (1996) Polym Mater Sci Engin Proc 74:416

    CAS  Google Scholar 

  90. Mallapragada SK, Peppas NA, Colombo P (1997) J Biomed Mater Res 36:125

    Article  CAS  Google Scholar 

  91. Narasimhan B, Snaar JEM, Bowtell RW, Morgan S, Melia CD, Peppas NA (1999) Macromolecules 32:704

    Article  CAS  Google Scholar 

  92. Snaar JEM, Bowtell R, Melia CD, Morgan S, Narasimhan B, Peppas (1998) Magnetic Resonance Imaging 16:691

    Article  CAS  Google Scholar 

  93. Gudeman LF, Peppas NA (1995) J Membr Sci 107:239

    Article  CAS  Google Scholar 

  94. Gudeman LF, Peppas NA (1995) J Appl Polym Sci 55:919

    Article  CAS  Google Scholar 

  95. Hickey AS, Peppas NA (1997) Polymer 38:5931

    Article  CAS  Google Scholar 

  96. Peppas NA, Hickey AS (1997) In: Peppas NA, Mooney DJ, Mikos AG, Brannon Peppas L (eds) Biomaterials: carriers for drug delivery and scaffolds for tissue engineering. AIChE, New York, pp 328–330

    Google Scholar 

  97. Peppas NA, Wright SL (1996) Macromolecules 29:8798

    Article  CAS  Google Scholar 

  98. Peppas NA, Wright SL (1996) Report Poval Committee 108:96

    Google Scholar 

  99. Peppas NA, Wright SL (1998) Eur J Pharm and Biopharm 46:15

    Article  CAS  Google Scholar 

  100. Argade AB, Peppas NA (1998) J Appl Polym Sci 70:817

    Article  CAS  Google Scholar 

  101. Shin HS, Kim SY, Lee YM (1997) J Appl Polym Sci 65:685

    Article  CAS  Google Scholar 

  102. Shin HS, Kim SY, Lee YM, Lee KH, Kim SJ, Rogers CE (1998) J Appl Polym Sci 69:479

    Article  CAS  Google Scholar 

  103. Llanos GR, Sefton MV (1991) Macromolecules 24:6066

    Article  Google Scholar 

  104. Sawatari C (1996) Toyota Kenkyu Hokoku 49:77

    CAS  Google Scholar 

  105. Inamura I (1986) Polym J 18:269

    Article  CAS  Google Scholar 

  106. Inamura I, Akiyama K, Kubo Y (1997) Polym J 29:119

    Article  CAS  Google Scholar 

  107. Masaro L, Zhu XX (1998) Macromolecules 31:3880

    Article  CAS  Google Scholar 

  108. Peppas NA, Merrill EW (1977) J Biomed Mater Res 11:423

    Article  CAS  Google Scholar 

  109. Peppas NA, Merrill EW (1977) J Appl Polym Sci 21:1763

    Article  CAS  Google Scholar 

  110. Peppas NA, Benner RE Jr, Sorensen, RA (1979) Proc IUPAC 26:1539

    Google Scholar 

  111. Peppas NA, Benner RE Jr (1980) Biomaterials 1:158

    Article  CAS  Google Scholar 

  112. Peppas NA (1977) Polym Prepr 18(1):794

    Google Scholar 

  113. Tamura K, Ike O, Hitomi S, Isobe J, Shimizu Y, Nambu M (1986) Trans Amer Soc Artif Organs 32:605

    CAS  Google Scholar 

  114. Fujimoto K, Minato M, Ikada Y (1994) In: Shalaby SW, Ikada Y, Langer R, Williams J (eds) ACS Symposium Series 540, Polymers of biological and biomédical significance. Plenum Press, New York, pp 228–241

    Google Scholar 

  115. Oka M, Naguchi T, Kumar P, Ikeuchi K, Yamamuno T, Hyon SH, Ikada Y (1990) Clinical Materials 6:361

    Article  CAS  Google Scholar 

  116. Noguchi T, Yamamuro T, Oka M, Kumar P, Kotoura Y, Hyon SH, Ikada Y (1991) J Appl Biomater 2:101

    Article  CAS  Google Scholar 

  117. Cha WI, Hyon SH, Ikada Y (1996) Macromol Symp 109:115

    CAS  Google Scholar 

  118. Scotchford CA, Cascone MG, Downes S, Giusti P (1998) Biomaterials 19:1

    Article  CAS  Google Scholar 

  119. Sorensen RA, Peppas NA (1979) Proc IUPAC 26:1108

    Google Scholar 

  120. Reinhart CT, Korsmeyer RW, Peppas NA (1981) Int J Pharm Techn 2(2):9

    CAS  Google Scholar 

  121. Korsmeyer RW, Peppas NA (1981) J Membr Sci 9:211

    Article  CAS  Google Scholar 

  122. Gander B, Gurny R, Doelker E, Peppas NA (1983) Proc Int Symp Control Rel Pharm 5

    Google Scholar 

  123. Gander B, Gurny R, Doelker E, Peppas NA (1989) Pharm Res 6:578

    Article  CAS  Google Scholar 

  124. Gander B, Gurny R, Doelker E, Peppas NA (1988) Proc Int Symp Contr Rel Bioactiv Mater 15:109

    Google Scholar 

  125. Kim CJ, Lee (1990) Polym Mater Sci Eng Proc 63:64

    CAS  Google Scholar 

  126. Morimoto K, Nagayasu A, Fukanoki S, Morisaka K, Hyon SH, Ikada Y (1989) Pharm Res 6:338

    Article  CAS  Google Scholar 

  127. Morimoto K, Fukanoki S, Morisaka K, Hyon SH, Ikada, Y (1989) Chem Pharm Bull 37:2491

    CAS  Google Scholar 

  128. Tsutsumi K, Takayama K, Machida Y, Ebert CD, Nakatomi I, Nagai T (1994) STP Pharma Sci 4:230

    CAS  Google Scholar 

  129. Peppas NA, Yang WH (1980) Proc IUPAC 27(4):28

    Google Scholar 

  130. Cha WI, Hyon SH, Ikada Y (1991) Kobunshi Ronbunshu 48:425

    CAS  Google Scholar 

  131. Hyon SH, Cha WI, Ikada Y, Kita M, Ogura Y, Honda Y (1994) J Biomater Sci Polymer Edn 5:397

    Article  CAS  Google Scholar 

  132. Kuriaki M, Nakamura K, Mizutani J (1989) Kobunshi Ronbunshu 46:739

    CAS  Google Scholar 

  133. Hirai T, Maruyama H, Nemoto H, Suzuki T, Hayashi S (1990) Polym Prepr Jpn (Engl Ed) 39:942

    Google Scholar 

  134. Hirai T, Nemoto H, Suzuki T, Hayashi S (1991) Polym Prepr Jpn (Engl Ed) 40:1297

    Google Scholar 

  135. Hirai T, Maruyama H, Suzuki T, Hayashi S (1992) J Appl Polym Sci 46:1449

    Article  CAS  Google Scholar 

  136. Hirai T, Maruyama H, Suzuki T, Hayashi S (1992) J Appl Polym Sci 45:1849

    Article  CAS  Google Scholar 

  137. Okazaki M, Hamada T, Fujii H, Mizobe A, Matsuzawa S (1995) J Appl Polym Sci 58:2235

    Article  CAS  Google Scholar 

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  1. Polymer Science and Engineering Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907-1283, USA

    Christie M. Hassan & Nikolaos A. Peppas

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  1. Christie M. Hassan
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Hassan, C.M., Peppas, N.A. (2000). Structure and Applications of Poly(vinyl alcohol) Hydrogels Produced by Conventional Crosslinking or by Freezing/Thawing Methods. In: Biopolymers · PVA Hydrogels, Anionic Polymerisation Nanocomposites. Advances in Polymer Science, vol 153. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-46414-X_2

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  • DOI: https://doi.org/10.1007/3-540-46414-X_2

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