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The structure and reactivity of arsenic compounds: Biological activity and drug design

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Bioinorganic Chemistry

Part of the book series: Structure and Bonding ((STRUCTURE,volume 78))

Abstract

Arsenic is a potentially essential element for mammals and is abundant in certain marine organisms. Arsenic compounds have been widely used as drugs in the past and were used until recently as growth promoters for some farm animals. Here we review the structures, reactivities and biological and pharmacological activities of arsenic compounds, emphasising both the similarities to and differences from other Group V elements (P, Sb, Bi). There appear to be no crystal structures of As-containing peptides or proteins, and the inhibition of thiol-enzymes by As(III), although widely quoted, is poorly understood. There is much scope for the design of arsenic compounds as drugs, but progress depends on the discovery of new probes for investigating the structural and redox chemistry and biochemistry of arsenic, especially in aqueous media.

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  1. Department of Chemistry, Birkbeck College, University of London, Gordon House, 29 Gordon Square, WC1H 0PP, London, UK

    Orla M. Ni Dhubhghaill & Peter J. Sadler

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Ni Dhubhghaill, O.M., Sadler, P.J. (1991). The structure and reactivity of arsenic compounds: Biological activity and drug design. In: Bioinorganic Chemistry. Structure and Bonding, vol 78. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-54261-2_3

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