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Microbial Models for Drug Metabolism

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Biotransformations

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((4143,volume 63))

Abstract

This review describes microbial transformation studies of drugs, comparing them with the corresponding metabolism in animal systems, and providing technical methods for developing microbial models. Emphasis is laid on the potential for selected microorganisms to mimic all patterns of mammalian biotransformations and to provide preparative methods for structural identification and toxicological and pharmacological studies of drug metabolites.

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  1. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Unité Associée au CNRS N∘ 400, Université René Descartes-Paris V, 45 rue des Saints-Pères, 75270, Paris Cedex 06, France

    R. Azerad

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  1. Institute of Organic Chemistry, University of Graz, Heinrichstraße 28, A-8010, Graz, Austria

    Kurt Faber

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Azerad, R. (1999). Microbial Models for Drug Metabolism. In: Faber, K. (eds) Biotransformations. Advances in Biochemical Engineering/Biotechnology, vol 63. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-69791-8_8

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