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Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing pp 197–220Cite as

Role of ADARs in Mouse Development

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 353))

Abstract

RNA editing by deamination of adenosine to inosine (A-to-I editing) is a physiologically important posttranscriptional mechanism that can regulate expression of genes by modifying their transcripts. A-to-I editing is mediated by adenosine deaminases acting on RNA (ADAR) that can catalytically exchange adenosines to inosines, with varying efficiency, depending on the structure of the RNA substrates. Significant progress in understanding the biological function of mammalian ADARs has been made in the past decade by the creation and analysis of gene-targeted mice with disrupted or modified ADAR alleles. These studies have revealed important roles of ADARs in neuronal and hematopoietic tissue during embryonic and postnatal stages of mouse development.

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Acknowledgments

Work in C.R.W’s laboratory is supported by grants from the National Health and Medical Research Council (NHMRC) Australia; C.R.W. is the Philip Desbrow Seniro Research Fellow of the Leukaemia Foundation.

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Authors and Affiliations

  1. St. Vincent’s Institute of Medical Research and Department of Medicine, St. Vincent’s Hospital, University of Melbourne, Melbourne, VIC, 3065, Australia

    Carl R. Walkley & Brian Liddicoat

  2. TaconicArtemis GmbH, Neurather Ring 1, 51063, Koeln, Germany

    Jochen C. Hartner

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  1. Carl R. Walkley
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  2. Brian Liddicoat
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Correspondence to Jochen C. Hartner .

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  1. , Dept. of Molecular, Cellular and Develop, University of California, Santa Barbara, Santa Barbara, 93106, California, USA

    Charles E. Samuel

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Walkley, C.R., Liddicoat, B., Hartner, J.C. (2011). Role of ADARs in Mouse Development. In: Samuel, C. (eds) Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing. Current Topics in Microbiology and Immunology, vol 353. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2011_150

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