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Swine Influenza Virus Vaccines: To Change or Not to Change—That’s the Question

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Swine Influenza

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 370))

Abstract

Commercial vaccines currently available against swine influenza virus (SIV) are inactivated, adjuvanted, whole virus vaccines, based on H1N1 and/or H3N2 and/or H1N2 SIVs. In keeping with the antigenic and genetic differences between SIVs circulating in Europe and the US, the vaccines for each region are produced locally and contain different strains. Even within a continent, there is no standardization of vaccine strains, and the antigen mass and adjuvants can also differ between different commercial products. Recombinant protein vaccines against SIV, vector, and DNA vaccines, and vaccines attenuated by reverse genetics have been tested in experimental studies, but they have not yet reached the market. In this review, we aim to present a critical analysis of the performance of commercial inactivated and novel generation SIV vaccines in experimental vaccination challenge studies in pigs. We pay special attention to the differences between commercial SIV vaccines and vaccination attitudes in Europe and in North America, to the issue of vaccine strain selection and changes, and to the potential advantages of novel generation vaccines over the traditional killed SIV vaccines.

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Acknowledgments

The authors would like to acknowledge grant support from the National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Services (Contract No. HHSN266200700005C), the European Commission (FP7—GA258084, FLUPIG), and the Belgian Federal Public Service for Health, Food Safety and Environment (RT 09/6227, FLUCROSS).

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Authors and Affiliations

  1. Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium

    Kristien Van Reeth

  2. Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, K224B Mosier Hall, Manhattan, KS, 66506, USA

    Wenjun Ma

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  1. Kristien Van Reeth
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Correspondence to Kristien Van Reeth .

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Editors and Affiliations

  1. Science and Techn. Ctr. of Excellence, College of Veterinary Medicine, Kansas State University, Mosier Hall K-224B, Manhattan, 66506-5601, Kansas, USA

    Jürgen A. Richt

  2. Dept. Infectious Diseases (ID), Div. Virology, St. Jude Children's Research Hospital, N. Lauderdale St. 332, Memphis, 38105, Tennessee, USA

    Richard J. Webby

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Van Reeth, K., Ma, W. (2012). Swine Influenza Virus Vaccines: To Change or Not to Change—That’s the Question. In: Richt, J., Webby, R. (eds) Swine Influenza. Current Topics in Microbiology and Immunology, vol 370. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_266

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