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Transcriptional Control of Pre-B Cell Development and Leukemia Prevention

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Transcriptional Control of Lineage Differentiation in Immune Cells

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 381))

Abstract

The differentiation of early B cell progenitors is controlled by multiple transcriptional regulators and growth-factor receptors. The triad of DNA-binding proteins, E2A, EBF1, and PAX5 is critical for both the early specification and commitment of B cell progenitors, while a larger number of secondary determinants, such as members of the Ikaros, ETS, Runx, and IRF families have more direct roles in promoting stage-specific pre-B gene-expression program. Importantly, it is now apparent that mutations in many of these transcription factors are associated with the progression to acute lymphoblastic leukemia. In this review, we focus on recent studies that have shed light on the transcriptional hierarchy that controls efficient B cell commitment and differentiation as well as focus on the oncogenic consequences of the loss of many of the same factors.

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Acknowledgments

This work was supported by a National Health and Medical Research Council (NHRMC) of Australia program grant (575500 to S.L.N). S.H.M.P. was supported by the Leukaemia Foundation of Australia, S.L.N. by an Australian Research Council Future Fellowship and S.C. by an NHMRC Career Development Fellowship. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS.

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia

    Swee Heng Milon Pang, Sebastian Carotta & Stephen L. Nutt

  2. Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia

    Swee Heng Milon Pang, Sebastian Carotta & Stephen L. Nutt

  3. Boehringer Ingelheim RCV, Oncology Research, Dr. Boehringer Gasse 5-11, A1121, Vienna, Austria

    Sebastian Carotta

Authors
  1. Swee Heng Milon Pang
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  2. Sebastian Carotta
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  3. Stephen L. Nutt
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Corresponding author

Correspondence to Stephen L. Nutt .

Editor information

Editors and Affiliations

  1. Medical University of Vienna, Division of Immunobiology, Institute of Immunology, Center of Pathophysiology,Infectiology and Immunology, Vienna, Wien, Austria

    Wilfried Ellmeier

  2. RIKEN Center for Integrative Medical Sciences, IMS,, Laboratory for Transcriptional Regulation,, Yokohama, Kanagawa, Japan

    Ichiro Taniuchi

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© 2014 Springer International Publishing Switzerland

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Pang, S.H.M., Carotta, S., Nutt, S.L. (2014). Transcriptional Control of Pre-B Cell Development and Leukemia Prevention. In: Ellmeier, W., Taniuchi, I. (eds) Transcriptional Control of Lineage Differentiation in Immune Cells. Current Topics in Microbiology and Immunology, vol 381. Springer, Cham. https://doi.org/10.1007/82_2014_377

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