Abstract
The numerous discoveries that have elucidated the basic mechanisms of the assembly of the transcription machinery and the factors that regulate gene expression have been discussed elsewhere in this book. Here we address another layer of complexity intrinsic to the transcription machinery, namely, its role in maintaining genomic integrity. First, the transcription machinery specifically facilitates the repair of damaged template DNA in the transcribed strand of active genes. In addition to damaged DNA, collisions between the transcription and replication machineries represent a source of genomic instability and are thus regulated by the coordination of these two processes. Finally, the transcription machinery plays an active role during the cell’s response to DNA damage by up-regulating certain genes to cope with the damage and down-regulating other genes. We will discuss the detailed mechanisms of these processes to highlight the contribution of the transcription machinery to the maintenance of the genomic integrity of the cell.
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References
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Poisson, J.M., Chen, Y., Sanchez, Y. (2006). Transcription and Genomic Integrity. In: Ma, J. (eds) Gene Expression and Regulation. Springer, New York, NY. https://doi.org/10.1007/978-0-387-40049-5_25
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