Definition
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder that is primarily characterized by motor dysfunction.
Description
Idiopathic Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder that affects around 1/1,000 individuals [36]. The pathology of this disorder is focused on the substantia nigra (SN) and nigrostriatal tract, resulting in the motor symptoms that characterize this disorder [5]. Onset occurs most commonly after the age of 50 and its incidence increases with advancing age [11]. While PD is primarily characterized by motor dysfunction, signs of early cognitive disturbances are also a feature of the disease process [6, 28, 34]. The end consequence of this cognitive decline may be frank dementia. Indeed, research indicates that a substantial number of individuals with PD (∼40%) will progress to a diagnosis of dementia (see [12] for review).
Motor Symptoms
Tremor, rigidity, bradykinesia and postural instability...
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McKinlay, A. (2011). Parkinson’s Disease. In: Goldstein, S., Naglieri, J.A. (eds) Encyclopedia of Child Behavior and Development. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-79061-9_2084
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