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Parkinson’s Disease

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Definition

Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder that is primarily characterized by motor dysfunction.

Description

Idiopathic Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder that affects around 1/1,000 individuals [36]. The pathology of this disorder is focused on the substantia nigra (SN) and nigrostriatal tract, resulting in the motor symptoms that characterize this disorder [5]. Onset occurs most commonly after the age of 50 and its incidence increases with advancing age [11]. While PD is primarily characterized by motor dysfunction, signs of early cognitive disturbances are also a feature of the disease process [6, 28, 34]. The end consequence of this cognitive decline may be frank dementia. Indeed, research indicates that a substantial number of individuals with PD (∼40%) will progress to a diagnosis of dementia (see [12] for review).

Motor Symptoms

Tremor, rigidity, bradykinesia and postural instability...

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References

  1. Aarsland, D., Andersen, K., Larsen, J. P., Lolk, A., & Kragh-Sorensen, P. (2003). Prevalence and characteristics of dementia in Parkinson disease: An 8-year prospective study. Archives of Neurology, 60(3), 387–392.

    PubMed  Google Scholar 

  2. Aarsland, D., Zaccai, J., & Brayne, C. (2005). A systematic review of prevalence studies of dementia in Parkinson’s disease. Movement Disorders, 20(10), 1255–1263.

    PubMed  Google Scholar 

  3. Berardelli, A., Rothwell, J. C., Thompson, P. D., & Hallett, M. (2001). Pathophysiology of bradykinesia in Parkinson’s disease. Brain, 124(Pt. 11), 2131–2146.

    PubMed  Google Scholar 

  4. Biggins, C. A., Boyd, J. L., Harrop, F. M., Madeley, P., Mindham, R. H., Randall, J. I., et al. (1992). A controlled, longitudinal study of dementia in Parkinson’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 55(7), 566–571.

    PubMed  Google Scholar 

  5. Braak, H., & Braak, E. (2000). Pathoanatomy of Parkinson’s disease. Journal of Neurology, 247(Suppl. 2), II3–II10.

    PubMed  Google Scholar 

  6. Brown, R. G., & Marsden, C. D. (1990). Cognitive function in Parkinson’s disease: From description to theory. Trends in Neurosciences, 13(1), 21–29.

    PubMed  Google Scholar 

  7. Bruck, A., Aalto, S., Nurmi, E., Bergman, J., & Rinne, J. O. (2005). Cortical 6-[18F]fluoro-L-dopa uptake and frontal cognitive functions in early Parkinson’s disease. Neurobiology of Aging, 26(6), 891–898.

    PubMed  Google Scholar 

  8. Caparros-Lefebvre, D., Pecheux, N., Petit, V., Duhamel, A., & Petit, H. (1995). Which factors predict cognitive decline in Parkinson’s disease? Journal of Neurology, Neurosurgery, and Psychiatry, 58(1), 51–55.

    PubMed  Google Scholar 

  9. Carr, J. (2002). Tremor in Parkinson’s disease. Parkinsonism & Related Disorders, 8(4), 223–234.

    Google Scholar 

  10. Damier, P., Hirsch, E. C., Agid, Y., & Graybiel, A. M. (1999). The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson’s disease. Brain, 122(Pt. 8), 1437–1448.

    PubMed  Google Scholar 

  11. de Rijk, M. C., Tzourio, C., Breteler, M. M., Dartigues, J. F., Amaducci, L., Lopez-Pousa, S., et al. (1997). Prevalence of parkinsonism and Parkinson’s disease in Europe: The EUROPARKINSON Collaborative Study. European community concerted action on the epidemiology of Parkinson’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 62(1), 10–15.

    PubMed  Google Scholar 

  12. Emre, M. (2003). Dementia associated with Parkinson’s disease. The Lancet Neurology, 2, 229–237.

    Google Scholar 

  13. Gibb, W. R. (1997). Functional neuropathology in Parkinson’s disease. European Neurology, 38(Suppl. 2), 21–25.

    PubMed  Google Scholar 

  14. Graham, J. M., & Sagar, H. J. (1999). A data-driven approach to the study of heterogeneity in idiopathic Parkinson’s disease: Identification of three distinct subtypes. Movement Disorders, 14(1), 10–20.

    PubMed  Google Scholar 

  15. Haber, S. N. (2003). The primate basal ganglia: Parallel and integrative networks. Journal of Chemical Neuroanatomy, 26(4), 317–330.

    PubMed  Google Scholar 

  16. Herrero, M. T., Barcia, C., & Navarro, J. M. (2002). Functional anatomy of thalamus and basal ganglia. Childs Nervous System, 18(8), 386–404.

    Google Scholar 

  17. Hobson, P., & Meara, J. (2004). Risk and incidence of dementia in a cohort of older subjects with Parkinson’s disease in the United Kingdom. Movement Disorders, 19(9), 1043–1049.

    PubMed  Google Scholar 

  18. Hughes, T. A., Ross, H. F., Musa, S., Bhattacherjee, S., Nathan, R. N., Mindham, R. H., et al. (2000). A 10-year study of the incidence of and factors predicting dementia in Parkinson’s disease. Neurology, 54(8), 1596–1602.

    PubMed  Google Scholar 

  19. Jankovic, J. (2003). Pathophysiology and clinical assessment of Parkinsonian symptoms and signs. In R. Pahwa, K. E. Lyons, & W. C. Koller (Eds.), Handbook of Parkinson’s disease (3rd ed., pp. 71–107). New York: Marcel Dekker, Inc.

    Google Scholar 

  20. Jellinger, K. A. (1999). Post mortem studies in Parkinson’s disease – is it possible to detect brain areas for specific symptoms? Journal of Neural Transmission. Supplementum, 56, 1–29.

    PubMed  Google Scholar 

  21. Kang, G. A., Bronstein, J. M., Masterman, D. L., Redelings, M., Crum, J. A., & Ritz, B. (2005). Clinical characteristics in early Parkinson’s disease in a central California population-based study. Movement Disorders, 20(9), 1133–1142.

    PubMed  Google Scholar 

  22. Lawrence, A. D., Hodges, J. R., Rosser, A. E., Kershaw, A., French-Constant, C., Rubinsztein, D. C., et al. (1998). Evidence for specific cognitive deficits in preclinical Huntington’s disease. Brain, 121(Pt. 7), 1329–1341.

    PubMed  Google Scholar 

  23. Lawrence, A. D., Sahakian, B. J., Hodges, J. R., Rosser, A. E., Lange, K. W., & Robbins, T. W. (1996). Executive and mnemonic functions in early Huntington’s disease. Brain, 119(Pt. 5), 1633–1645.

    PubMed  Google Scholar 

  24. Levy, G., Jacobs, D. M., Tang, M. X., Cote, L. J., Louis, E. D., Alfaro, B., et al. (2002). Memory and executive function impairment predict dementia in Parkinson’s disease. Movement Disorders, 17(6), 1221–1226.

    PubMed  Google Scholar 

  25. Lewis, S. J., Caldwell, M. A., & Barker, R. A. (2003). Modern therapeutic approaches in Parkinson’s disease. Expert Reviews in Molecular Medicine, 5, 1–20.

    PubMed  Google Scholar 

  26. Lewis, S. J., Foltynie, T., Blackwell, A. D., Robbins, T. W., Owen, A. M., & Barker, R. A. (2005). Heterogeneity of Parkinson’s disease in the early clinical stages using a data driven approach. Journal of Neurology, Neurosurgery, and Psychiatry, 76(3), 343–348.

    PubMed  Google Scholar 

  27. Mahieux, F., Fenelon, G., Flahault, A., Manifacier, M. J., Michelet, D., & Boller, F. (1998). Neuropsychological prediction of dementia in Parkinson’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 64(2), 178–183.

    PubMed  Google Scholar 

  28. Marsh, L. (2000). Neuropsychiatric aspects of Parkinson’s disease. Psychosomatics, 41(1), 15–23.

    PubMed  Google Scholar 

  29. Middleton, F. A., & Strick, P. L. (2000). Basal ganglia output and cognition: Evidence from anatomical, behavioral, and clinical studies. Brain and Cognition, 42(2), 183–200.

    PubMed  Google Scholar 

  30. Mindham, R. H. (1999). The place of dementia in Parkinson’s disease: A methodologic saga. Advances in Neurology, 80, 403–408.

    PubMed  Google Scholar 

  31. Obeso, J. A., Rodriguez-Oroz, M. C., Rodriguez, M., Lanciego, J. L., Artieda, J., Gonzalo, N., et al. (2000). Pathophysiology of the basal ganglia in Parkinson’s disease. Trends in Neurosciences, 23(Suppl. 10), S8–S19.

    PubMed  Google Scholar 

  32. Ring, H. A., & Serra-Mestres, J. (2002). Neuropsychiatry of the basal ganglia. Journal of Neurology, Neurosurgery, and Psychiatry, 72(1), 12–21.

    PubMed  Google Scholar 

  33. Rinne, J. O. (1993). Nigral degeneration in Parkinson’s disease. Movement Disorders, 8(Suppl. 1), S31–S35.

    PubMed  Google Scholar 

  34. Shulman, L. M., Taback, R. L., Bean, J., & Weiner, W. J. (2001). Comorbidity of the nonmotor symptoms of Parkinson’s disease. Movement Disorders, 16(3), 507–510.

    PubMed  Google Scholar 

  35. Stern, Y., Tang, M. X., Jacobs, D. M., Sano, M., Marder, K., & Bell, K. (1998). Prospective comparative study of the evolution of probable Alzheimer’s disease and Parkinson’s disease dementia. Journal of the International Neuropsychological Society, 4, 279–284.

    PubMed  Google Scholar 

  36. Twelves, D., Perkins, K. S., & Counsell, C. (2003). Systematic review of incidence studies of Parkinson’s disease. Movement Disorders, 18(1), 19–31.

    PubMed  Google Scholar 

  37. Uitti, R. J., Baba, Y., Wszolek, Z. K., & Putzke, D. J. (2005). Defining the Parkinson’s disease phenotype: Initial symptoms and baseline characteristics in a clinical cohort. Parkinsonism & Related Disorders, 11(3), 139–145.

    Google Scholar 

  38. Yelnik, J. (2002). Functional anatomy of the basal ganglia. Movement Disorders, 17(Suppl. 3), S15–S21.

    PubMed  Google Scholar 

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McKinlay, A. (2011). Parkinson’s Disease. In: Goldstein, S., Naglieri, J.A. (eds) Encyclopedia of Child Behavior and Development. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-79061-9_2084

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  • DOI: https://doi.org/10.1007/978-0-387-79061-9_2084

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-77579-1

  • Online ISBN: 978-0-387-79061-9

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