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Book cover Osteoporosis Research

Abstract

Osteoporosis is a disease characterized by low bone mass and micro-architectural deterioration of bone tissue leading to skeletal fragility. Guidelines established by the United States Food and Drug Administration (FDA) stipulate that therapeutic treatments formulated to attenuate or prevent postmenopausal osteoporosis should, in the first instance, be evaluated in an ovariectomized (OVX) rodent such as the rat.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Susan Reinwald

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  1. Susan Reinwald
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  2. David B. Burr
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Correspondence to Susan Reinwald .

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  1. Nepean Hospital, Dept. Geriatric Medicine, University of Sydney, Penrith, 2750, New South Wales, Australia

    Gustavo Duque

  2. Department of Bone & Joint Disease, National Center for Geriatrics & Geronto, Obu-Aichi, Japan

    Ken Watanabe

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Reinwald, S., Burr, D.B. (2011). Other Large Animal Models. In: Duque, G., Watanabe, K. (eds) Osteoporosis Research. Springer, London. https://doi.org/10.1007/978-0-85729-293-3_13

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