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Calcium Signalling and Calcium Transport in Bone Disease

  • Chapter
Calcium Signalling and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 45))

Abstract

Calcium transport and calcium signalling mechanisms in bone cells have, in many cases, been discovered by study of diseases with disordered bone metabolism. Calcium matrix deposition is driven primarily by phosphate production, and disorders in bone deposition include abnormalities in membrane phosphate transport such as in chondrocalcinosis, and defects in phosphate-producing enzymes such as in hypophosphatasia. Matrix removal is driven by acidification, which dissolves the mineral. Disorders in calcium removal from bone matrix by osteoclasts cause osteopetrosis. On the other hand, although bone is central to management of extracellular calcium, bone is not a major calcium sensing organ, although calcium sensing proteins are expressed in both osteoblasts and osteoclasts. Intracellular calcium signals are involved in secondary control including cellular motility and survival, but the relationship of these findings to specific diseases is not clear. Intracellular calcium signals may regulate the balance of cell survival versus proliferation or anabolic functional response as part of signalling cascades that integrate the response to primary signals via cell stretch, estrogen, tyrosine kinase, and tumor necrosis factor receptors

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Authors and Affiliations

  1. Departments of Pathology and of Cell Biology and Physiology, University of Pittsburgh and Veterans’ Affairs Health System, Pittsburgh, PA 15261, U.S.A

    H.C. BLAIR

  2. Department of Physiology and Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A

    P.H. SCHLESINGER

  3. Physiological Laboratory, University of Cambridge, Cambridge, CB2 3EG, United Kingdom

    C.L.-H. HUANG

  4. The Bone Program, Mount Sinai School of Medicine, New York, New York 10029, U.S.A

    M. ZAIDI

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  1. University of Padova, Padova, Italy

    Ernesto Carafoli

  2. University of Padova, Padova, Italy

    Marisa Brini

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BLAIR, H., SCHLESINGER, P., HUANG, CH., ZAIDI, M. (2007). Calcium Signalling and Calcium Transport in Bone Disease. In: Carafoli, E., Brini, M. (eds) Calcium Signalling and Disease. Subcellular Biochemistry, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6191-2_21

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