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Determination of Myocardial Material Properties by Optimization

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Computational Cardiovascular Mechanics

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Abstract

The previous chapter includes a computationally efficient strain energy function for describing the three-dimensional relationship between stress and strain in passive myocardial material properties, the material parameters of which were formally optimized using left ventricular pressure and epicardial strain measurements in a cylindrical model. Results from such a model are confined at best to the equatorial region of the left ventricle. A finite element model of the entire left ventricle is required to determine regional variations in myocardial material properties. The most important or at least interesting finding from such a study is that myocardial contractility in the (border zone) region adjacent to a myocardial infarction is much less than (typically only half) that in regions remote from the myocardial infarction. This finding has been confirmed with active stress measurements in skinned muscle fibers dissected from these regions. This chapter is concerned with brief descriptions of the studies from our laboratory that have led up to our current knowledge concerning regional variations of myocardial contractility in infarcted left ventricles.

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Acknowledgments

This research was supported by a grant from the Whitaker Foundation (Dr. Guccione) and National Institutes of Health grant 5R01 HL077921 (Dr. Guccione).

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Authors and Affiliations

  1. Department of Surgery, University of California at San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA

    Jonathan F. Wenk, Choon-Sik Jhun, Kay Sun & Julius M. Guccione

  2. Livermore Software Technology Corporation, Livermore, CA, USA

    Nielen Stander

Authors
  1. Jonathan F. Wenk
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  2. Choon-Sik Jhun
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  3. Kay Sun
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  4. Nielen Stander
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  5. Julius M. Guccione
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Correspondence to Julius M. Guccione .

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Editors and Affiliations

  1. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Julius M. Guccione

  2. Purdue University Indianapolis, Indiana University, Barnhill Drive 635, Indianapolis, 46202, U.S.A.

    Ghassan S. Kassab

  3. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Mark B. Ratcliffe

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Wenk, J.F., Jhun, CS., Sun, K., Stander, N., Guccione, J.M. (2010). Determination of Myocardial Material Properties by Optimization. In: Guccione, J., Kassab, G., Ratcliffe, M. (eds) Computational Cardiovascular Mechanics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0730-1_4

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  • DOI: https://doi.org/10.1007/978-1-4419-0730-1_4

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0729-5

  • Online ISBN: 978-1-4419-0730-1

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