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Integrating the Epidemiology and Pathogenesis of Schizophrenia from the Street to the Striatum: Integrating the Epidemiology and Pathogenesis of Schizophrenia

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Advances in Schizophrenia Research 2009

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Abstract

Research into schizophrenia has proceeded in a patchwork manner as if isolated portions of a giant jigsaw were being completed with little thought as to how these might contribute to the whole picture. For example, investigations into the two major pathogenic theories of schizophrenia, namely the dopamine hypothesis and the neurodevelopmental hypothesis, proceeded for many years in parallel with little cross-talk. Only recently have there been attempts to integrate the two theories, with our group concluding that dopamine dysregulation is the final step in a complex developmental cascade that starts early in life and ends with the onset of full-blown psychosis (Murray et al., 2008a).

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Authors and Affiliations

  1. Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King’s College London, De Crespigny Park, SE5 8AF, London, UK

    Robin M. Murray

  2. Institute of Psychiatry, De Crespigny Park, Box PO63, SE5 8AF, London, UK

    Marta Di Forti & Oliver Howes

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  1. Robin M. Murray
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  2. Marta Di Forti
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  3. Oliver Howes
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Correspondence to Robin M. Murray .

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Editors and Affiliations

  1. Fac. Medicina, Universidade de São Paulo, Rua Ovídio Pires Campos 785, Sao Paulo, 05403-903, Brazil

    Wagner F. Gattaz

  2. Fac. Medicina, Universidade de São Paulo, Rua Ovídio Pires Campos 785, Sao Paulo, 05403-903, Brazil

    Geraldo Busatto

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Murray, R.M., Forti, M.D., Howes, O. (2010). Integrating the Epidemiology and Pathogenesis of Schizophrenia from the Street to the Striatum: Integrating the Epidemiology and Pathogenesis of Schizophrenia. In: Gattaz, W., Busatto, G. (eds) Advances in Schizophrenia Research 2009. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0913-8_19

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  • DOI: https://doi.org/10.1007/978-1-4419-0913-8_19

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